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Triazenes

Chemical, Biological, and Clinical Aspects

  • Book
  • © 1990

Overview

Editors:
  1. Tullio Giraldi

    1. Istituto di Farmacologia, Università di Trieste, Trieste, Italy

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  2. Thomas A. Connors

    1. Toxicology Unit, Medical Research Council, Carshalton, Surrey, UK

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  3. Giuseppe Cartei

    1. Divisione di Oncologia Medica, Ospedale S. Maria della Misericordia, Udine, Italy

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii
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  2. Triazenes: Synthesis and Chemical Properties

    • Keith Vaughan
    Pages 1-13

  3. Mechanisms of the Biological Actions of Triazenes

    • M. J. Tisdale
    Pages 15-22

  4. Triazenes and Triazene N-Oxides: Antitumour Action in Animal Tumour Systems

    • Derry E. V. Wilman
    Pages 23-43

  5. Antimestastatic Action of Triazene Derivatives

    • Tullio Giraldi, Laura Perissin, Sonia Zorzet, Valentina Rapozzi
    Pages 45-62

  6. Effects of Triazenes on Immune Responses

    • Stefania D’Atri, Lucio Tentori, Maria Tricarico, Enzo Bonmassar
    Pages 63-77

  7. Xenogenization of Experimental Tumors by Triazene Derivatives

    • Paolo Puccetti, Luigina Romani, Ursula Grohmann, Roberta Bianchi, Patrizia Fuschiotti, Massimo Allegrucci et al.
    Pages 79-89

  8. The Metabolism of Antineoplastic Triazenes

    • Andreas Gescher, Lincoln L. H. Tsang, John A. Slack
    Pages 91-96

  9. Notes on the Metabolism, Pharmacokinetics and Mode of Action of N-Methyl and N-Ethyl-Triazenes in Relation to Their Pharmacological Activity

    • Maurizio D’Incalci, Tina Colombo, Pierluigi Farina Cecilia Mannironi, Pietro Taverna, Carlo V. Catapano
    Pages 97-107

  10. Clinical Use of Triazenes

    • Sándor Eckhardt
    Pages 109-118

  11. Clinical Studies with the p-Carboxyl Dimethyl Phenyl Triazene CB10-277

    • David R. Newell, Brenda J. Foster, James Carmicheal, Adrian L. Harris, Karen Jenns, Lyndsey Gumbrell et al.
    Pages 119-131

  12. Triazenes: Therapeutic Considerations and Perspectives

    • G. Cartei
    Pages 133-144

  13. Antitumour Imidazotetrazinones: Prodrugs Targeted to the Major Groove of DNA

    • Malcolm F. G. Stevens
    Pages 145-159

  14. O6-Alkylguanine-DNA-Alkyltransferase Gene Expression and the Cytotoxicity of Triazenes

    • G. P. Margison, L. C. Harris, L. Cernakova, V. Vlckova, J. Brozmanova, K. Kleibl et al.
    Pages 161-172

  15. N-Methylmelamines, a Unique Class of Anti-Tumour Agents?

    • I. R. Judson
    Pages 173-184

  16. Experimental Background and Early Clinical Studies with Imidazotetrazine Derivatives

    • E. S. Newlands, G. R. P. Blackledge, J. Slack, N. S. A. Stuart, M. F. G. Stevens
    Pages 185-193

  17. O6-Alkylguanine-DNA-Alkyltransferase: Significance, Methods of Measurement and Some Human Tumour and Normal Tissue Levels

    • G. P. Margison, P. J. O’Connor, D. P. Cooper, J. Davies, C. N. Hall, S. M. S. Redmond et al.
    Pages 195-206

  18. Summary of Poster-Sessions

    • E. Bonmassar, A. Gescher, D. R. Newell, M. F. G. Stevens
    Pages 207-211

  19. Back Matter

    Pages 213-227
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Keywords

Reviews

From Book News, Inc.
A class of antitumor agents is discussed in 16 papers, which include explorations of the synthesis, chemical properties, biotransformation, and pharmacokinetics in animals and humans, and studies of analogous agents and substances affecting the mechanism of triazenes. Specific topics include antimetastatic action, immune responses, xenogenization, clinical use, and therapeutic considerations.
Annotation copyright Book News, Inc. Portland, Or.

Editors and Affiliations

  • Istituto di Farmacologia, Università di Trieste, Trieste, Italy

    Tullio Giraldi

  • Toxicology Unit, Medical Research Council, Carshalton, Surrey, UK

    Thomas A. Connors

  • Divisione di Oncologia Medica, Ospedale S. Maria della Misericordia, Udine, Italy

    Giuseppe Cartei

Bibliographic Information

  • Book Title: Triazenes

  • Book Subtitle: Chemical, Biological, and Clinical Aspects

  • Editors: Tullio Giraldi, Thomas A. Connors, Giuseppe Cartei

  • DOI: https://doi.org/10.1007/978-1-4615-3832-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1990

  • Hardcover ISBN: 978-0-306-43667-3Published: 01 January 1991

  • Softcover ISBN: 978-1-4613-6710-9Published: 17 October 2012

  • eBook ISBN: 978-1-4615-3832-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 227

  • Topics: Oncology, Cancer Research, Biochemistry, general

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