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The Paramyxoviruses

  • Book
  • © 1991

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Editors:
  1. David W. Kingsbury

    1. Howard Hughes Medical Institute, Bethesda, USA

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Part of the book series: The Viruses (VIRS)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xxi
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  2. The Genetics of Paramyxoviruses

    • Craig R. Pringle
    Pages 1-39

  3. The Molecular Biology of the Paramyxovirus Genus

    • Mark S. Galinski, Steven L. Wechsler
    Pages 41-82

  4. The Molecular Biology of the Morbilliviruses

    • Thomas Barrett, Shaila M. Subbarao, Graham J. Belsham, Brian W. J. Mahy
    Pages 83-102

  5. The Molecular Biology of Human Respiratory Syncytial Virus (RSV) of the Genus Pneumovirus

    • Peter L. Collins
    Pages 103-162

  6. Evolutionary Relationships of Paramyxovirus Nucleocapsid-Associated Proteins

    • Exeen M. Morgan
    Pages 163-179

  7. The Nonstructural Proteins of Paramyxoviruses

    • Robert A. Lamb, Reay G. Paterson
    Pages 181-214

  8. Paramyxovirus RNA Synthesis and P Gene Expression

    • Daniel Kolakofsky, Sylvia Vidal, Joseph Curran
    Pages 215-233

  9. Function of Paramyxovirus 3′ and 5′ End Sequences

    • Benjamin M. Blumberg, John Chan, Stephen A. Udem
    Pages 235-247

  10. The Role of Viral and Host Cell Proteins in Paramyxovirus Transcription and Replication

    • Sue A. Moyer, Sandra M. Horikami
    Pages 249-274

  11. Deletion Mutants of Paramyxoviruses

    • Gian Guido Re
    Pages 275-298

  12. Paramyxovirus Persistence

    • R. E. Randall, W. C. Russell
    Pages 299-321

  13. Molecular Biology of Defective Measles Viruses Persisting in the Human Central Nervous System

    • Martin A. Billeter, Roberto Cattaneo
    Pages 323-345

  14. Structure, Function, and Intracellular Processing of the Glycoproteins of Paramyxoviridae

    • Trudy Morrison, Allen Portner
    Pages 347-382

  15. The Unusual Attachment Glycoprotein of the Respiratory Syncytial Viruses

    • Wayne M. Sullender, Gail W. Wertz
    Pages 383-406

  16. New Frontiers Opened by the Exploration of Host Cell Receptors

    • Mary Ann K. Markwell
    Pages 407-425

  17. Paramyxovirus M Proteins

    • Mark E. Peeples
    Pages 427-456

  18. Intracellular Targeting and Assembly of Paramyxovirus Proteins

    • Ranjit Ray, Laurent Roux, Richard W. Compans
    Pages 457-479

  19. Immunobiology of Paramyxoviruses

    • Erling Norrby
    Pages 481-507

  20. Epidemiology of Paramyxoviridae

    • Francis L. Black
    Pages 509-536
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Keywords

About this book

What justifies the size of this compendium of reviews on the paramyxoviruses? As intracellular parasites that reproduce with almost complete indifference to nuclear activities, paramyxoviruses have not been providing insights about genes that regulate cellular activities and development, topics that account for much of the excitement in modem biology. For contributions of virus research to those topics, we must look to the retroviruses, which have the propensity to steal developmentally important genes and subvert them to malignant pur­ poses, and to the nuclear DNA viruses, whose gene expression depends heavily upon cellular transcription machinery, making them exceptionally useful tools for identifying and characterizing components of that machinery. From this perspective, it may appear that purely lytic viruses like the paramyxoviruses are sitting on the sidelines of contemporary biology. But there is plenty of action on the sidelines. Paramyxoviruses remain unconquered, devastating agents of disease. Human deaths attributable to paramyxoviruses worldwide, especially in children, are numbered in the mil­ lions annually. There are many pathogenic paramyxoviruses and too few effec­ tive vaccines, and those vaccines (against measles and mumps) are affordable only by relatively affluent nations. Moreover, the paramyxoviruses are intrin­ sically interesting organisms, presenting the challenge of understanding the self-replication of RNA and many other challenges peculiar to the structures and functions of their proteins, not only as individual entities, but also as they act in concert during virus reproduction and interact with vital functions of the cells they infect and often (but not always) destroy.

Editors and Affiliations

  • Howard Hughes Medical Institute, Bethesda, USA

    David W. Kingsbury

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