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Breast Epithelial Antigens

Molecular Biology to Clinical Applications

  • Book
  • © 1991

Overview

Editors:
  1. Roberto L. Ceriani

    1. John Muir Cancer and Aging Research Institute, Walnut Creek, USA

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Session I

    1. Molecular Analysis of H23 Epithelial Tumor Antigen - Differentially Spliced Full Length cDNAs and Gene

      • D. H. Wreschner, I. Tsarfaty, M. Hareuveni, J. Zaretsky, N. I. Smorodinsky, S. Zrihan et al.
      Pages 1-13

    2. Characterization and Evolution of an Expressed Hypervariable Gene for a Tumor-Associated Mucin, MUC-1

      • Sandra J. Gendler, Andrew P. Spicer, Lucy Pemberton, Carole A. Lancaster, Trevor Duhig, Nigel Peat et al.
      Pages 15-23

    3. Structure, Processing, Differential Glycosylation and Biology of Episialin

      • J. Hilkens, M. J. L. Ligtenberg, S. Litvinov, H. L. Vos, A. M. C. Gennissen, F. Buys et al.
      Pages 25-34

    4. Molecular Cloning and Expression of Breast Mucin-Associated Antigens

      • D. Larocca, J. A. Peterson, R. Urrea, J. Kuniyoshi, A. Bistrain, G. Walkup et al.
      Pages 35-44

    5. Monoclonal Antibodies Reactive with Breast Cancer, Mammary Mucins and Synthetic Peptides

      • Pei-xiang Xing, Ian F. C. McKenzie
      Pages 45-54

    6. Molecular Analysis of Epitopic Heterogeneity of the Breast Mucin

      • Jerry A. Peterson, David Larocca, Gary Walkup, Richard Amiya, Roberto L. Ceriani
      Pages 55-68

  3. Session II

    1. Expression and Prognostic Significance of the HER-2/neu Oncogene During the Evolutionary Progression of Human Breast Cancer

      • D. Craig Allred, Atul K. Tandon, Gary M. Clark, William L. McGuire
      Pages 69-82

    2. Structure and Function of MFG-E8: A Novel Apical Membrane Protein of Mouse Mammary Epithelial Cells

      • Gordon Parry, Christine Lekutis, Karen Singer, Anhthu Bui, Dale Yuzuki, John Stubbs
      Pages 83-89

    3. Targeted Lysis of Human Breast Cancer Cells by Human Effector Cells Armed with Bispecific Antibody 2B1 (ANTI-c-erbB-2 / ANTI-Fcγ Receptor III)

      • David B. Ring, Tim Shi, Sylvia T. Hsieh-Ma, John Reeder, Audrey Eaton, Jeffrey Flatgaard
      Pages 91-104

    4. Mechanisms Controlling Steroid Receptor Binding to Specific DNA Sequences

      • Dean P. Edwards, Patricia A. Estes, Sergio Oñate, Candace A. Beck, Angelo M. DeMarzo, Steven K. Nordeen
      Pages 105-116

  4. Session III

    1. Origin and Nature of the Milk Lipid Globule Membrane

      • Thomas W. Keenan, Daniel P. Dylewski
      Pages 117-129

    2. N-Linked Oligosaccharide Synthesis and Cellular Sociology

      • Armando J. Parodi
      Pages 131-140

    3. Development of Enzyme Immunoassays for Breast Carcinoma-Associated Mucin Antigens

      • Joseph P. Brown, Rose Beer, Sidney Наllam, Patricia Stewart, Kristi Stob, Ted A. W. Splinter
      Pages 141-150

    4. Clinical Studies and New Developments with Hybri-BREScan (CA-549), A Monoclonal Assay for Breast Cancer-Associated Antigen

      • Kurtis R. Bray, Isaac A. Mizrahi, Marie-Jeanne Yerna
      Pages 151-159

    5. Evaluation of Several Tumor Markers (MCA, CA 15.3, BCM and CA 549) in Tissue and Serum of Patients with Breast Cancer

      • Rafael Molina, Antonio M. Ballesta
      Pages 161-168

    6. IMx BCM: A Novel Monoclonal Based System for the Detection of Breast Cancer Associated Mucin

      • John G. Konrath, Louise W. Przywara, Donald M. Lynch, Kim K. Borden, Albert L. Sorrell, Ruthie L. Thillen et al.
      Pages 169-182

    7. A Novel Serum Assay Using Recombinant Breast Epithelial Mucin Antigen

      • Roberto L. Ceriani, David Larocca, Jerry A. Peterson, Richard Amiya, Sean Enloe, Edward W. Blank
      Pages 183-193

  5. Session IV

    1. RadioimmunoguidedTM Surgery in Breast Cancer

      • Carol A. Nieroda, Edward Martin Jr.
      Pages 195-209

    2. Immuno-Pharmacologic Purging of Breast Cancer from Bone Marrow

      • E. J. Shpall, R. C. Bast Jr., C. S. Johnson, W. P. Peters, R. B. Jones
      Pages 211-214
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Keywords

About this book

The wealth of research results in the area of breast cancer diagnosis and therapy with monoclonal antibodies presented in previous workshops is now complemented with a new rendition of the proceedings of the 4th Workshop on Monoclonal Antibodies and Breast Cancer. held in San Francisco on November 5-6. 1990. Basic science findings reported in previous workshops have now percolated to the clinical level and have become immunoassays and imaging and therapy reagents. as the program shows us. Thus. the latest discoveries in immunology. biochemistry and molecular biology of breast epithelial antigens and their corresponding antibodies have produced newer diagnostic tests and therapeutic approaches that are altering and improving the way we attack breast cancer. The recent spectacular and rapid advancements in the molecular biology of several of the breast epithelial antigens are presented in this volume. The way in which the final assembly of different components of the breast antigens is achieved and their functions are now within our grasp as a result of new understanding of molecular structure of these breast antigens. In addition. newer immunoassays aiming at the earliest detection of the disease are also described that integrate with promising attempts at imaging and radioimmunotherapy to set the stage for new oncological possibilities in breast cancer treatment. All these areas of intense involvement of scientists with diverse specialties are presented in this volume. which proves the need for multidisciplinary approaches to increase our chances for success in this field of medical research.

Editors and Affiliations

  • John Muir Cancer and Aging Research Institute, Walnut Creek, USA

    Roberto L. Ceriani

Bibliographic Information

  • Book Title: Breast Epithelial Antigens

  • Book Subtitle: Molecular Biology to Clinical Applications

  • Editors: Roberto L. Ceriani

  • DOI: https://doi.org/10.1007/978-1-4615-3740-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1991

  • Hardcover ISBN: 978-0-306-44009-0Published: 30 September 1991

  • Softcover ISBN: 978-1-4613-6665-2Published: 18 October 2012

  • eBook ISBN: 978-1-4615-3740-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 246

  • Topics: Biochemistry, general, Oncology, Immunology

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