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Chemical Carcinogenesis 2

Modulating Factors

  • Book
  • © 1991

Overview

Editors:
  1. Amedeo Columbano

    1. University of Cagliari, Cagliari, Italy

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  2. Francesco Feo

    1. University of Sassari, Sassari, Italy

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  3. Rosa Pascale

    1. University of Sassari, Sassari, Italy

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  4. Paolo Pani

    1. University of Cagliari, Cagliari, Italy

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Table of contents (62 chapters)

  1. Front Matter

    Pages i-xii
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  2. Oncogenes and Cancer Development

    1. Front Matter

      Pages 1-1
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    2. Nuclear Oncogenes as Transcription Factors

      • P. Sassone-Corsi, S. J. Busch, F. Schlotter, J. Auwerx, B. Mellström, N. S. Foulkes et al.
      Pages 3-9

    3. Control of Hepatocyte Growth by Positive and Negative Growth Regulators and Mitogenic Triggers: Implications for Hepatic Neoplasia

      • G. K. Michalopoulos
      Pages 11-17

    4. Cell Cycle Dependent Regulation of Poly(ADP-Ribose) Polymerase Gene Expression

      • A. Carcereri De Prati, M. Menegazzi, G. M. Ledda Columbano, A. Columbano, M. Miwa, H. Suzuki
      Pages 19-27

    5. Different Expression of Cell Cycle Related Genes during Liver Regeneration and Liver Hyperplasia

      • P. Coni, G. Pichiri-Coni, G. M. Ledda-Columbano, P. M. Rao, S. Rajalakshmi, D. S. R. Sarma et al.
      Pages 29-38

    6. S-Adenosylmethionine Content, DNA Methylation and Gene Expression in Regenerating Liver

      • M. M. Simile, M. A. Seddaiu, M. E. Ruggiu, G. Vannini, G. Satta, M. J. Sequenza et al.
      Pages 39-47

    7. Gene Activation and Deactivation during Multistage Hepatocarcinogenesis in the Rat

      • H. C. Pitot, M. J. Neveu, J. H. Hully, L. Sargent, D. Paul, B. Nicholson
      Pages 49-64

    8. Biochemical and Molecular Perturbations Induced in Preneoplastic Tissue by a S-Adenosyl-L-Methionine Load

      • R. Pascale, M. M. Simile, M. E. Ruggiu, L. Daino, G. Satta, M. A. Seddaiu et al.
      Pages 65-86

    9. Alterations of Cell Surface Receptors and Expression of Cellular Oncogenes in the Liver of Rats Fed a Hypolipidemic Peroxisome Proliferator

      • L. L. Hsieh, I. B. Weinstein, J. M. Betschart, M. A. Virji, H. Shinozuka
      Pages 87-97

    10. Growth Hormone-Regulated Expression of the c-myc Gene during Sex-Differentiated Promotion of Rat Liver Carcinogenesis

      • I. Porsch Hällström, A. Blanck
      Pages 99-109

    11. In Situ Hybridization of Ha-RAS during Rat Liver Carcinogenesis

      • V. Préat, Y. Nizet, S. Haesen, M. Roberfroid
      Pages 111-118

    12. Mutations in the H-ras Proto-Oncogene in Early Precancerous Liver Lesions of the B6C3F1 Mouse

      • A. Buchmann, J. Mahr, R. Bauer-Hofmann, M. Schwarz
      Pages 119-121

    13. Transformation of Human Epithelial Cells by Recombinant Human Papillomavirus DNA Associated with Cervical Cancer

      • J. A. DiPaolo, P. Bowden, N. C. Popescu, C. D. Woodworth
      Pages 123-135

  3. Genetic Factors

    1. Front Matter

      Pages 137-137
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    2. Cancer Families and Susceptibility to Cancer

      • F. P. Li
      Pages 139-144

    3. Cancer Syndromes in Humans

      • M. E. Kazanecki, T. J. Gill III
      Pages 145-157

    4. Case-Control Studies on Cancer Risk in G6PD-Deficient Male Populations

      • P. L. Cocco, S. Dessi, P. Manca, R. Cherchi, M. Pisano, P. F. Todde
      Pages 159-164

    5. Genetic Susceptibility to Murine Hepatocarcinogenesis

      • T. A. Dragani, G. Manenti, B. M. Colombo, G. Della Porta
      Pages 165-176

    6. MHC-Linked Genes Controlling Growth and Reproduction Influence the Susceptibility to Diethylnitrosamine-Induced Carcinogenesis

      • M. F. Melhem, A. L. Cortese-Hassett, M. Kazaneki, K. N. Rao, H. W. Kunz, T. J. Gill III
      Pages 177-186
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Keywords

About this book

"chemical carcinogenesis" is the general title of the series of international meetings which are held, biannually, in sardinia (Italy) since 1981. Despite the generality of the title, the main effort of the scientific Committee has been to pursue a coherent line around one of the most distinguishing features of carcinogenesis: the "multifasic" development of the process. Given that many chemical compounds are known to cause "experimental cancer", many questions still remain unresolved or are given too simplistic answers. The very first question concerning the interaction between the chemical carcinogen and the molecular target in the cell is a debatable one despite the overwhelming literature in this field. It is certain that chemical carcinogens are toxic to cells and cause DNA damage: however it is still an open question as to how to relate these changes to the different stages of carcinogenesis including initiation. We have not to forget that 1/3 to 2/3 of the average life time of a given species elapses between the experimental administration of the carcinogen and the appearance of "cancer". The experimental manipulation of carcinogenesis through the use of "adequate biological models" has not simplified the problems about cancer, but it has led us to face the complexity of otherwise elementary biological properties, cell proliferation and differentiation. The understanding of this biological complexity is not just theoretical, but it may give us those adequate conceptual tools to approach "cancer" also from a medical point of view.

Editors and Affiliations

  • University of Cagliari, Cagliari, Italy

    Amedeo Columbano, Paolo Pani

  • University of Sassari, Sassari, Italy

    Francesco Feo, Rosa Pascale

Bibliographic Information

  • Book Title: Chemical Carcinogenesis 2

  • Book Subtitle: Modulating Factors

  • Editors: Amedeo Columbano, Francesco Feo, Rosa Pascale, Paolo Pani

  • DOI: https://doi.org/10.1007/978-1-4615-3694-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1991

  • Hardcover ISBN: 978-0-306-43896-7Published: 30 June 1991

  • Softcover ISBN: 978-1-4613-6642-3Published: 05 November 2012

  • eBook ISBN: 978-1-4615-3694-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 653

  • Topics: Oncology

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