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Innovations in Antiviral Development and the Detection of Virus Infections

  • Book
  • © 1992

Overview

Editors:
  1. Timothy M. Block

    1. Thomas Jefferson University Hospital, Philadelphia, USA

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  2. Donald Jungkind

    1. Thomas Jefferson University Hospital, Philadelphia, USA

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  3. Richard L. Crowell

    1. Hahnemann University School of Medicine, Philadelphia, USA

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  4. Mark Denison

    1. Vanderbilt University, Nashville, USA

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  5. Lori R. Walsh

    1. Mercy Catholic Medical Center, Darby, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 312)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Studies of Reovirus Pathogenesis Reveal Potential Sites for Antiviral Intervention

    • Bernard N. Fields
    Pages 1-14

  3. Drugs as Molecular Tools

    • Frank J. Dutko, Donald E. Baright, Guy D. Diana, M. Pat Fox, Daniel C. Pevear, Mark A. McKinlay
    Pages 15-24

  4. Genetically Engineered Bacteria to Identify and Produce Anti-Viral Agents

    • Robert H. Grafstrom, Katherine Zachariasewycz, Richard A. Brigandi, Timothy M. Block
    Pages 25-40

  5. Antiviral Agents from Novel Marine and Terrestrial Sources

    • Kenneth L. Rinehart
    Pages 41-60

  6. Virus Receptors: The Achilles’ Heel of Human Rhinoviruses

    • Richard J. Colonno
    Pages 61-70

  7. Therapeutic Strategies Employing CD4, the HIV Receptor

    • Per Ashorn, Bernard Moss, Edward A. Berger
    Pages 71-81

  8. Molecular Characterization of HIV-2 (ROD) Protease Following PCR Cloning from Virus Infected H9 Cells

    • Y.-S. Edmond Cheng, Catherine E. Patterson, Ronald G. Rucker, Michael J. Otto, Christopher J. Rizzo, Bruce D. Korant
    Pages 83-88

  9. A Novel, Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase (Review)

    • Vincent J. Merluzzi, Alan S. Rosenthal
    Pages 89-94

  10. Catalytic Antisense RNA (Ribozymes): Their Potential and Use as ANTI-HIV-1 Therapeutic Agents

    • John J. Rossi, Nava Sarver
    Pages 95-109

  11. Therapies for Hepatitis B Virus: Current Status and Future Possibilities

    • Paul Martin, Lawrence S. Friedman
    Pages 111-120

  12. A Preliminary Report of a Controlled Study of Thymosin Alpha-1 in the Woodchuck Model of Hepadnavirus Infection

    • John L. Gerin, Brent E. Korba, Paul J. Cote, Bud C. Tennant
    Pages 121-123

  13. Delta Virus as a Vector for the Delivery of Biologically-Active RNAs: Possibly a Ribozyme Specific for Chronic Hepatitis B Virus Infection

    • Sen-Yung Hsieh, John Taylor
    Pages 125-128

  14. Inhibition of Herpes Simplex Virus Ribonucleotide Reductase by Synthetic Nonapeptides: A Potential Antiviral Therapy

    • Michel Liuzzi, Erika Scouten, Rolf Ingemarson
    Pages 129-138

  15. Antiviral Effects of Herpes Simplex Virus Specific Anti-Sense Nucleic Acids

    • Edouard M. Cantin, Gregory Podsakoff, Dru E. Willey, Harry Openshaw
    Pages 139-149

  16. Heterogeneity of a Herpes Simplex Virus Clinical Isolate Exhibiting Resistance to Acyclovir and Foscarnet

    • Emanuela Pelosi, Karen A. Hicks, Stephen L. Sacks, Donald M. Coen
    Pages 151-158

  17. Cellular Metabolism and Enzymatic Phosphorylation of 9- (2-Phosphonylmethoxyethyl) Guanine (PMEG),a Potent Antiviral Agent

    • Hsu-Tso Ho, Kathleen L. Woods, Sherry A. Konrad, Hilde De Boeck, Michael J. M. Hitchcock
    Pages 159-166

  18. Effect of Herpes Simplex Virus Type 1 Infection on Cytokine Gene Expression in Activated Murine Peritoneal Macrophages

    • Linxian Wu, Toby K. Eisenstein, Page S. Morahan
    Pages 167-172

  19. Procedure for Evaluation of Neutralizing Antibody to Cytomegalovirus in Commercial Intravenous Gamma Globulin Preparations

    • Cindy Wordell, Lorena Chambers, Maryann Durante, Sue DiRenzo, Leigh Hopkins, Donald Jungkind
    Pages 173-182

  20. Improved Detection of Antibodies to Hepatitis C Virus Using a Second Generation Elisa

    • Stephen Lee, John McHutchinson, Brian Francis, Robert DiNello, Alan Polito, Stella Quan et al.
    Pages 183-189
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Keywords

About this book

THE ERA OF ANTIVIRALS Introduction Although there are more than one hundred medically useful antibiotics and fungicides, there are only seven compounds licensed for use as antiviral agents, in the USA. Some of these (acyclovir and ganciclovir) are actually derivatives of each other, making the number of new discoveries even smaller. Moreover, most of these agents are of only limited therapeutic value and have substantial toxicity. It has been more than 100 years ago since Pasteur studied rabies virus (2) and Rous (4) showed that a small filterable agent (not bacteria) caused disease (sarcoma) in chickens. It was nearly 100 years ago that yellow fever virus, the first recognized human pathogenic virus, was unambiguously associated with disease (3). Enteroviruses were cultured for the first time nearly 50 years ago (1). Why then has effective chemotherapy against viruses lagged behind that of other microorganisms? Viruses are often difficult to grow and image. However, with the dynamic advances in molecular biology and increased sophistication in tissue culture, the field of virology has blossomed and resulted in improved methods for detection of virus infection. The use of viruses as models of gene regulation and replication has also resulted in a massive accumulation of information.

Editors and Affiliations

  • Thomas Jefferson University Hospital, Philadelphia, USA

    Timothy M. Block, Donald Jungkind

  • Hahnemann University School of Medicine, Philadelphia, USA

    Richard L. Crowell

  • Vanderbilt University, Nashville, USA

    Mark Denison

  • Mercy Catholic Medical Center, Darby, USA

    Lori R. Walsh

Bibliographic Information

  • Book Title: Innovations in Antiviral Development and the Detection of Virus Infections

  • Editors: Timothy M. Block, Donald Jungkind, Richard L. Crowell, Mark Denison, Lori R. Walsh

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-3462-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1992

  • Hardcover ISBN: 978-0-306-44209-4Published: 30 June 1992

  • Softcover ISBN: 978-1-4613-6533-4Published: 28 October 2012

  • eBook ISBN: 978-1-4615-3462-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVII, 218

  • Topics: Infectious Diseases, Medical Microbiology, Plant Sciences, Animal Anatomy / Morphology / Histology, Microbial Ecology

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