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Pancreatic Islet Cell Regeneration and Growth

  • Book
  • © 1992

Overview

Editors:
  1. Aaron I. Vinik

    1. The Diabetes Institutes, Eastern Virginia Medical School, Norfolk, USA

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  2. David J. Sirman
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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 321)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    1. Introduction

      • Aaron I. Vinik
      Pages 1-5

  3. Regulation of Cell Growth and Development

    1. Front Matter

      Pages 7-7
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    2. The Role of Growth Hormone and Prolactin in Beta Cell Growth and Regeneration

      • Jens Høiriis Nielsen, Annette Møldrup, Nils Billestrup, Elisabeth Douglas Petersen, Giovanna Allevato, Matthias Stahl
      Pages 9-20

    3. The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration

      • Derek LeRoith, Haim Werner, Bartolome Burguera, Charles T. Roberts Jr., Susan Mulroney, Aviad Haramati
      Pages 21-30

    4. The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System

      • Thomas J. Lauterio
      Pages 31-36

    5. Growth Factor Expression in Normal and Diabetic Rats During Peripheral Nerve Regeneration through Silicone Tubes

      • Jean M. Le Beau
      Pages 37-44

    6. Oncogenes and Cell Growth

      • Timothy J. Bos
      Pages 45-51

    7. Interferon — A Candidate Mediator of Cell Growth

      • Bruce Tedeschi
      Pages 53-58

  4. Models for the Study of Cell Regeneration

    1. Front Matter

      Pages 59-59
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    2. Islet β-Cell Regeneration and Reg Genes

      • Michiaki Unno, Takako Itoh, Takuo Watanabe, Hikari Miyashita, Shigeki Moriizumi, Hiroshi Teraoka et al.
      Pages 61-69

    3. Factors Regulating Islet Regeneration in the Post-Insulinoma NEDH Rat

      • Ling Chen, Michael C. Appel, Tausif Alam, Chisato Miyaura, Andrea Sestak, John O’Neil et al.
      Pages 71-84

    4. Regeneration of Pancreatic Endocrine Cells in Interferon-Gamma Transgenic Mice

      • Nora E. Sarvetnick, Dangling Gu
      Pages 85-93

    5. Trophic Stimulation of the Ductular-Islet Cell Axis: A New Approach to the Treatment of Diabetes

      • Lawrence Rosenberg, Aaron I. Vinik
      Pages 95-109

  5. Induction of Cell Growth and Mechanisms

    1. Front Matter

      Pages 111-111
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    2. Expression of Insulin-Like Growth Factors (IGFs) and Their Binding Proteins (IGF BPs) During Pancreatic Development in Rat, and Modulation of IGF Actions on Rat Islet DNA Synthesis by IGF BPs

      • David J. Hill, Joanna Hogg
      Pages 113-122

    3. The Partial Isolation and Characterization of Ilotropin, a Novel Islet-Specific Growth Factor

      • Gary L. Pittenger, Aaron I. Vinik, Lawrence Rosenberg
      Pages 123-132

    4. Expression of Growth Factors in a Pancreatic Islet Regeneration Model

      • Ronit Rafaeloff, Lawrence Rosenberg, Aaron I. Vinik
      Pages 133-141

    5. Role of p21ras in Hormone Signalling and Cell Growth/Transformation

      • Peter F. Blackmore
      Pages 143-146

    6. Phosphoinositides and Cell Growth

      • William J. Wasilenko
      Pages 147-151
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Keywords

About this book

Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.

Editors and Affiliations

  • The Diabetes Institutes, Eastern Virginia Medical School, Norfolk, USA

    Aaron I. Vinik

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