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Treatment of Dementias

A New Generation of Progress

  • Book
  • © 1992

Overview

Editors:
  1. Edwin M. Meyer

    1. University of Florida, Gainesville, USA

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  2. James W. Simpkins

    1. University of Florida, Gainesville, USA

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  3. Jyunji Yamamoto

    1. Taiho Pharmaceutical Company, Tokushima, Japan

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  4. Fulton T. Crews

    1. University of Florida, Gainesville, USA

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Part of the book series: Advances in Behavioral Biology (ABBI, volume 40)

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Cholinergic Drugs in Alzheimer’s Treatment

    1. Front Matter

      Pages 1-2
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    2. Muscarinic Receptors: Molecular Biology and Neuropsychopharmacology

      • Elliott Richelson
      Pages 3-17

    3. Cholinomimetic Replacement of Cholinergic Function in Alzheimer Disease

      • Ezio Giacobini
      Pages 19-34

    4. The Muscarinic Modulation of Acetylcholine Release from the Rat: Neostriatum Changes with Senescence

      • Molly H. Weiler, Hwa-Jung Lee
      Pages 35-42

    5. Effects of Cholinergic Agents and Basal Forebrain Lesions in Rabbits

      • Jyunji Yamamoto, Kazuhiko Yonekura
      Pages 43-56

    6. Differential Effect of Aging on Hippocampal Pyramidal Cell Responses to Muscarine and Nicotine

      • Gregory M. Rose, David A. Engstrom
      Pages 57-73

    7. Modulation of Learning and Memory Via Benzodiazepine Receptors: Potential Treatments for Age-Related Dementia

      • Michael J. Forster, Harbans Lal
      Pages 75-84

    8. Acetylcholine-Somatostatin Interactions: Potential Implications for the Treatment of Alzheimer’s Disease

      • Lillian M. Shaffer, Shu-mei Ting, Linda A. Dokas
      Pages 85-96

  3. Growth Factors in Alzheimer’s Treatment

    1. Front Matter

      Pages 97-98
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    2. The Role of Neurotrophins in the Central Nervous System: Significance for the Treatment of Neurodegenerative Diseases

      • Paul A. Lapchak, Dalia M. Araujo, Millicent M. Dugich-Djordjevic, Franz Hefti
      Pages 99-111

    3. Contrasting Effects of Specific Lymphokines on the Survival of Hippocampal Neurons in Culture

      • Dalia M. Araujo
      Pages 113-122

    4. Growth Factor Regulation of Brain Protease Inhibitors

      • Kathleen T. Shiverick, Mohan K. Raizada, John A. Olson Jr.
      Pages 123-133

    5. Regulation of the Choline Acetyltransferase Gene

      • Louis B. Hersh, Chuang Kong Fong, Yi-Ping Li, Craig Sampson, Gabriele Mues, Dana Hilt et al.
      Pages 135-144

    6. Recombinant Human Nerve Growth Factor Increases Presynaptic Cholinergic Function Following Neuronal Damage: Implications for the Treatment of Alzheimer’s Disease

      • Paul A. Lapchak, Franz Hefti
      Pages 145-155

    7. Delayed Neuronal Death of Hippocampus (CA1) After Transient Global Ischemia: Does Nerve Growth Factor Protect Neurons Against “Killer Proteins” ?

      • Tatsuo Mima, Kintomo Takakura, Shoei Furukawa, Yoshihide Hashimoto, Gunshiro Kato, Yasundo Yamasaki et al.
      Pages 157-169

    8. Seizure-Dependent Regulation of BDNF mRNA in the Rat Brain

      • Millicent M. Dugich-Djordjevic, Paul A. Lapchak, Franz Hefti
      Pages 171-183

  4. Phospholipids in Alzheimer’s Treatment

    1. Front Matter

      Pages 185-185
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    2. Phosphatidylserine Stimulation of Macrophage Protein Secretion: Potential Healing and Trophic Mechanisms

      • Fulton T. Crews, Mark R. Potter, Ramesh Chander
      Pages 187-198

    3. Pharmacological Effects of Phosphatidylserine in the Aging Rat Brain

      • Maria Grazia Nunzi, Gino Toffano
      Pages 199-205
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Keywords

About this book

Alzheimer's disease is one the foremost health problems facing every society fortunate enough to attain a level of medical care that ensures an average lifespan of over 70 years of age. The cause of the disease remains unknown, and no single therapeutic approach has yet been found highly efficacious. Indeed, as the complexity of its effects on brain neuronal systems becomes elucidated, the concept emerges that Alzheimer's disease may be an umbrella term for multiple Alzheimer's-type syndromes that can be differentiated based on etiology (hereditary versus sporadic), neurochemical deficits, and extent of pathology. Whether one or more disease processes is involved, it seems increasingly unlikely that any single drug will provide efficacious relief across the broad spectrum of symptoms reflected in large subject populations. Rational therapeutic approaches may yield long term amelioration of many symptoms in selected groups of patients; and individual symptoms may be ameliorated in larger populations. Multiple approaches may be combined to optimize therapeutic effects. For example, a variety of approaches remain focused on restoration of cholinergic neurodegeneration and enhancing cholinergic neurotransmission, whereas other approaches attempt to retard the of the brain that occurs during Alzheimer's disease. Chapters cover continuous degeneration topics from growth factor secretion of proteases, which could modify amyloid processing, to neuronal gene delivery using viral vectors. The breadth and thoroughness of the chapters truly embrace a broad spectrurn of models, pathological mechanisms and therapeutic approaches.

Editors and Affiliations

  • University of Florida, Gainesville, USA

    Edwin M. Meyer, James W. Simpkins, Fulton T. Crews

  • Taiho Pharmaceutical Company, Tokushima, Japan

    Jyunji Yamamoto

Bibliographic Information

  • Book Title: Treatment of Dementias

  • Book Subtitle: A New Generation of Progress

  • Editors: Edwin M. Meyer, James W. Simpkins, Jyunji Yamamoto, Fulton T. Crews

  • Series Title: Advances in Behavioral Biology

  • DOI: https://doi.org/10.1007/978-1-4615-3432-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1992

  • Hardcover ISBN: 978-0-306-44228-5Due: 31 August 1992

  • Softcover ISBN: 978-1-4613-6518-1Published: 03 November 2011

  • eBook ISBN: 978-1-4615-3432-7Published: 06 December 2012

  • Series ISSN: 0099-6246

  • Edition Number: 1

  • Number of Pages: 448

  • Number of Illustrations: 31 b/w illustrations

  • Topics: Neurology, Neurosurgery, Pharmacology/Toxicology, Psychiatry, Neurosciences

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