Prostate Cancer and Bone Metastasis

1. Front Matter

   Pages i-ix

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2. Prostatic Cancer Bone Metastasis: An International Perspective

   1. Clinical Dilemmas and Problems in Assessing Prostatic Metastasis to Bone: The Scientific Challenge

      • John T. Grayhack, John J. Grayhack

      Pages 1-5

   2. Comparative Study of Prostatic Carcinoma Bone Metastasis among Japanese in Japan and Japanese Americans and Whites in Hawaii

      • Taizo Shiraishi, Shin-ichiro Atsumi, Ryuichi Yatani

      Pages 7-16

   3. Prostate Cancer in the United States and Japan

      • James P. Karr

      Pages 17-28

   4. Analysis of Survival of Prostate Cancer Patients in Japan and the USA

      • Kyoichi Imai, Takanori Suzuki, Toshihiro Shimizu, Hidetoshi Yamanaka, Hiroshi Kanetake, Hideki Sakai et al.

      Pages 29-38

3. Biology

   1. The Cellular Basis for Prostate Cancer Metastasis

      • Bruce R. Zetter, Marcela Chackal-Roy, Roy Smith

      Pages 39-43

   2. Cytogenetic and Molecular Genetic Aspects of Human Prostate Cancer: Primary and Metastatic

      • Avery A. Sandberg

      Pages 45-75

   3. Hemodynamics Of Prostate Bone Metastases

      • Martin I. Resnick

      Pages 77-81

   4. Role of the Vertebral Venous System in Metastatic Spread of Cancer Cells to the Bone

      • Masaoki Harada, Akio Shimizu, Yoshiyasu Nakamura, Ryosuke Nemoto

      Pages 83-92

   5. Clinical Significance of the Vertebral Vein in Prostate Cancer Metastasis

      • Yukiko Nishijima, Katsunori Uchida, Kenkichi Koiso, Ryosuke Nemoto

      Pages 93-100

   6. Effects of Various Growth Factors on a Chondrocyte Differentiation Model

      • Fujio Suzuki

      Pages 101-106

   7. Potential Role of HBGF (FGF) and TGF-Beta on Prostate Growth

      • Yuhsi Matuo, Wallace L. McKeehan, Guo-Chen Yan, Stathis Nikolaropoulos, Pamela S. Adams, Yoshitatsu Fukabori et al.

      Pages 107-114

   8. Hormone Refractory Prostatic Cancer: The Role of Radiolabelled Diphosphonates and Growth Factor Inhibitors

      • Howard I. Scher, Tracy Curley, Samuel Yeh, William Tong, Paul V. O’Moore, Steven Larson

      Pages 115-129

4. Models

   1. Localization of Basic Fibroblast Growth Factor (bFGF) in a Metastatic Cell Line (AT-3) Established from the Dunning Prostatic Carcinoma of Rat: Application of a Specific Monoclonal Antibody

      • Katsuzo Nishikawa, Yoshino Yoshitake, Masami Minemura, Kenji Yamada, Yuhsi Matuo

      Pages 131-139

   2. Use of a Reconstituted Basement Membrane to Study the Invasiveness of Tumor Cells

      • Yukihide Iwamoto, Yoichi Sugioka

      Pages 141-149

   3. Animal Prostate Carcinoma Models: Limited Potential for Vertebral Metastasis

      • Tomoyuki Shirai, Seiko Tamano, Satoru Takahashi, Nobuyuki Ito

      Pages 151-158

   4. A Model for Studies on Human Prostatic Carcinoma

      • Kenkichi Koiso, Tatsuo Iizumi

      Pages 159-163

5. Pathology

   1. Studies on the Pathogenesis of Osteoblastic Metastases by Prostate Cancer

      • David Goltzman, Isobel Bolivar, Shafaat A. Rabbani

      Pages 165-171

   2. Analysis of Bone Metastasis of Prostatic Adenocarcinoma in 137 Autopsy Cases

      • Masaoki Harada, Man-ichi Iida, Masanao Yamaguchi, Keizo Shida

      Pages 173-182

   3. Nucleolar Organizer Regions in Prostate Cancer

      • Satoru Kobayashi, Manabu Kuriyama, Naoki Yamamoto, Yoshito Takahashi, Ikuo Shinoda, Toshimi Takeuchi et al.

      Pages 183-188

The biology of solid tumor metastasis has been the subject of significant scientific and clinical interest for years and while experimental evidence reveals that metastasis is not solely a random event, very little is known about the biology of metastasis originating from prostate cancer. This is in spite of the fact that the majority of prostate cancer patients die with metastatic lesions to the bone. Progress in understanding this most important aspect of prostate cancer has been hampered by the lack of suitable animal models and an inability to accurately quantify bone metastases and their responses to therapy. Over the past decade, scientists in Japan and the United States have steadily advanced our understanding of the cellular, molecular and immunologic biology of primary and disseminated prostate cancer. It is this body of new information, combined with advances in imaging techniques and prostate cancer tumor markers, that prompted the need for an in-depth assessment of bone metastasis of prostate cancer. Accordingly, on December 12, 1990, a group of basic and clinical investigators from Japan and the United States convened in Gotenba, Japan, to hold the first conference devoted solely to the basic biology and clinical aspects of bone metastases originating from prostate cancer. The cross-fertilization of ideas that was fostered through in-depth discussion of technological advances among various basic and clinical disciplines not only further advanced our understanding of prostate metastases to the bone, but suggested approaches for precise quantitative assessment of these lesions and their treatment.

• assessment
• cancer
• imaging
• imaging techniques
• metastasis
• prostate cancer
• therapy
• treatment
• tumor

• Roswell Park Cancer Institute, Buffalo, USA

  James P. Karr

• Gunma University, Gunma, Japan

  Hidetoshi Yamanaka

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