Mechanisms of Lymphocyte Activation and Immune Regulation IV

1. Front Matter

   Pages i-ix

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2. T Cell Receptors and T Cell Activation

   1. Front Matter

      Pages 1-1

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   2. T Cell Receptor Structure and Function: Analysis by Expression of Portions of Isolated Subunits

      • Isaac Engel, Francois Letourneur, John T. B. Houston, Tom H. M. Ottenhoff, Richard D. Klausner

      Pages 1-7

   3. The T Cell Antigen Receptor Tyrosine Kinase Pathway

      • Lawrence E. Samelson, Mark Egerton, Pamela M. Thomas, Ronald L. Wange

      Pages 9-16

   4. Dissection of the Hb(64–76) Determinant Reveals That the T Cell Receptor May Have the Capacity to Differentially Signal

      • Brian D. Evavold, Paul M. Allen

      Pages 17-21

   5. CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1

      • Jeffrey A. Ledbetter, Peter S. Linsley

      Pages 23-27

   6. Structure and Function of CD45: A Leukocyte-Specific Protein Tyrosine Phosphatase

      • Ian S. Trowbridge, Pauline Johnson, Hanne Ostergaard, Nicholas Hole

      Pages 29-37

   7. Multidrug Resistant Gene 1 Product in Human T Cell Subsets: Role of Protein Kinase C Isoforms and Regulation by Cyclosporin A

      • Sudhir Gupta, Takashi Tsuruo, Sastry Gollapudi

      Pages 39-47

   8. Integrins, γδ T Cells, and Autoimmunity

      • Ethan M. Shevach

      Pages 49-55

   9. The Interleukin-2 Receptor: A Target for Immunotherapy

      • Thomas A. Waldmann, Carolyn Goldman, Lois Top, Angus Grant, Jack Burton, Richard Bamford et al.

      Pages 57-66

3. T Cell Development

   1. Front Matter

      Pages 67-67

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   2. Lymphocyte Development in Mice Deficient for MHC Class I Expression

      • David H. Raulet, Nan-Shih Liao, Isabel Correa, Mark Bix

      Pages 67-72

   3. Generation of Mutant Mice Lacking Surface Expression of CD4 or CD8 Gene Targeting

      • Tak W. Mak, Amin Rahemtulla, Marco Schilham, Dow Rhoon Koh, Wai Ping Fung-Leung

      Pages 73-77

   4. Alteration of T Cell Lineage Commitment by Expression of a Hybrid CD8/CD4 Transgene

      • Rho H. Seong, Jane R. Parnes

      Pages 79-87

   5. Differential Involvement of Protein Tyrosine Kinases p56lck and p59fyn in T Cell Development

      • Nicolai S. C. van Oers, Alex M. Garvin, Michael P. Cooke, Craig B. Davis, D. R. Littman, Roger M. Perlmutter et al.

      Pages 89-99

   6. Mechanism of Tolerance Induction

      • Ada M. Kruisbeek, John D. Nieland, Lori A. Jones

      Pages 101-109

4. B Cell Development, Activation, Proliferation, And Differentiation

   1. Front Matter

      Pages 111-111

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5. B Cell Development, Activation, Proliferation, and Differentiation

   1. B-Lymphocyte Lineage-Committed, IL-7 and Stroma Cell- Reactive Progenitors and Precursors, and Their Differentiation to B Cells

      • Fritz Melchers, Dirk Haasner, Martin Streb, Antonius Rolink

      Pages 111-117

   2. Regulatory Cells and Cytokines Involved in Primary B Lymphocyte Production

      • Kenneth Dorshkind, Ramaswamy Narayanan, Kenneth S. Landreth

      Pages 119-123

   3. The Role of IL-7 and Its Receptor in B-Cell Ontogeny

      • Linda S. Park, Philip J. Morrissey, Barry Davison, Kenneth Grabstein

      Pages 125-129

In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine phosphorylation. A role of src family phosphotyrosine kinases in T cell activation has been demonstrated and several phosphotyrosine kinase substrates have been identified and their functions characterized. Homologous recombinant techniques have led to the development of murine strains that lack CD4 or CD8 expression. These models are likely to be instrumental in studying the role of T cell subsets in autoimmune disorders, tissue transplant rejection and tumor rejection. A role of major histocompatibility complex I in the development of T cell subsets and NK cells has been defined. Recent data suggest a role of interaction between plasma membrane molecules of activated T helper cells and B cells, B cells primed with plasma membrane of activated T helper cells and cytokines, and interaction between bone marrow stromal cells and B cell progenitors and precursors, in the B cell development, proliferation, and differentiation. The structure and functions of adhesion molecules, especially with regard to signal transduction and homing events, are better defined.

• bone
• cells
• development
• plasma membrane
• tissue

• University of California, Irvine, USA

  Sudhir Gupta

• National Cancer Institute, National Institutes of Health, Bethesda, USA

  Thomas A. Waldmann

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