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Angiogenesis in Health and Disease

  • Book
  • © 1992

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Editors:
  1. Michael E. Maragoudakis

    1. University of Patras Medical School, Patras, Greece

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  2. Pietro Gullino

    1. University of Turin Medical School, Turin, Italy

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    You can also search for this editor in PubMed   Google Scholar

  3. Peter I. Lelkes

    1. University of Wisconsin Medical School, Milwaukee, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 227)

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Table of contents (52 chapters)

  1. Front Matter

    Pages i-ix
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  2. The Development of Vascular System

    1. Embryonic Development of Blood Vessels

      • Françoise Dieterlen-Lièvre, Luc Pardanaud
      Pages 1-15

    2. Regulation of Embryonic Blood Vessel Formation

      • Hannes Drexler, Harald Schnürch, Georg Breier, Werner Risau
      Pages 17-25

    3. Role of Heterotypic Interactions Between Endothelial Cells and Parenchymal Cells in Organspecific Differentiation: A Possible Trigger for Vasculogenesis

      • Peter I. Lelkes, Brian R. Unsworth
      Pages 27-41

    4. Role of the Macrophage in the Regulation of Physiological and Pathological Angiogenesis

      • Peter J. Polverini, Luisa A. DiPietro
      Pages 43-53

  3. Biology of Endothelial Cells and Angiogenesis

    1. Endothelial Cell Heterogeneity and Differentiation

      • Robert Auerbach, Johanna Plendl, Barmak Kusha
      Pages 55-62

    2. Heterogeneity in Endothelial Cells with Special Reference to their Growth Related Proteins

      • S. Kumar, P. Kumar, D. Pye, A. Sattar, M. Wang, J. Ponting
      Pages 63-78

    3. Basic Fibroblast Growth Factor and Endothelial Cells: Receptor Interaction, Signal Transduction, Cellular Response-Dissociation of the Mitogenic Activity of bFGF from its Plasminogen Activator-Inducing Capacity

      • Marco Presta, Marco Rusnati, Jeanette A. M. Maier, Chiara Urbinati, Massimo Statuto, Anna Gualandris et al.
      Pages 79-89

    4. Role of Integrins in Endothelial Cell Function

      • Elisabetta Dejana, Adriana Zanetti, Carmen Dominguez-Jimenez, Grazia Conforti
      Pages 91-98

    5. Specific Laminin Domains Mediate Endothelial Cell Adhesion, Alignment and Angiogenesis

      • D. S. Grant, J. Kinsella, M. C. Cid, H. K. Kleinman
      Pages 99-110

    6. Production of Plasminogen Activators and Matrix Metalloproteinases by Endothelial Cells: Their Role in Fibrinolysis and Local Proteolysis

      • Victor W. M. van Hinsbergh, Pieter Koolwijk
      Pages 111-126

    7. Heparin Coordinately Suppresses Endothelial Cell Plasminogen Activator Inhibitor-1, Fibronectin and Thrombospondin mRNA Levels

      • Bernadette Lyons-Giordano, Jane M. Brinker, Nicholas A. Kefalides
      Pages 127-133

    8. Properties of Endothelial and Smooth Muscle Cells Grown in 3-Dimensional Collagen Lattices

      • Robert Alper, Nicholas A. Kefalides
      Pages 135-141

    9. Effect of Ischaemia on Endothelial Cells

      • O. Hudlicka, S. Egginton, J. M. Dawson
      Pages 143-147

  4. Angiogenesis in Disease States

    1. Angiogenesis and Neoplastic Transformation

      • Pietro M. Gullino
      Pages 149-155

    2. Vascular Proliferation in Tumours and its Influence on Cancer Therapy

      • Juliana Denekamp
      Pages 157-171

    3. The Development of the Tumour Vascular System: 2-D and 3-D Approaches to Network Formation in Human Xenografted Tumours

      • M. A. Konerding, C. van Ackern, F. Steinberg, C. Streffer
      Pages 173-184

    4. Tumor Induced Angiogenesis: Effect of Platelet Derived Growth Factor (PDGF), Pentoxifylline, Sodium Diethyldithiocarbamate, Epsilon Amino Caproic Acid and Tranexamic Acid

      • J. L. Ambrus, C. M. Ambrus, C. A. Toumbis, P. Forgach, C. P. Karakousis, P. Niswander
      Pages 185-194

    5. Vascular Growth in the Intermittently Ischemic Heart: A Study on Growth Factors Expression

      • Hari S. Sharma, Martin Wünsch, Stefan Sack, Wolfgang Schaper
      Pages 195-206

    6. Role of Mechanical Factors in Angiogenesis under Physiological and Pathophysiological Circumstances

      • O. Hudlicka
      Pages 207-215
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Keywords

About this book

Angiogenesis describes the formation of new blood vessels, which arise as outgrowths from existing vessels. In many physiological processes such as ovulation and wound healing angiogenesis is involved for a relatively short time. Otherwise under normal physiological conditions in the adult organism angiogenesis is an extremely slow process. By contrast in certain disease states such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, etc., angiogenesis persists and contributes to the pathology of these disease states. Some 50 such "angiogenic diseases" have been described where angiogeneSiS is involved. Also in tumor growth and metastasis angiogenesis is an essential process and precedes neoplastic transformation. Hence, angiogenesis could become an important diagnostic tool and a target for developing therapeutic agents. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis in Health and Disease" held in Porto Hydra, Greece, from June 16-27, 1991. This meeting was a comprehensive review of endothelial cell biology and endothelial cell phenotypic and functional heterogeneity in relation to angiogenesis under physiological and pathological conditions. Numerous in vitro and in vivo models were presented, which are used to study angiogenesis at the molecular and cellular levels and to evaluate chemical compounds or naturally occuring substances for their effect on angiogenesis. The presentations and discussions at this meeting provided an opportunity for the basic science and the clinical disciplines to meet, exchange information and provide future research directions for many investigators engaged in the study of angiogenesis.

Editors and Affiliations

  • University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  • University of Turin Medical School, Turin, Italy

    Pietro Gullino

  • University of Wisconsin Medical School, Milwaukee, USA

    Peter I. Lelkes

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