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Combination Therapies

Biological Response Modifiers in the Treatment of Cancer and Infectious Diseases

  • Book
  • © 1992

Overview

Editors:
  1. Allan L. Goldstein

    1. The George Washington University School of Medicine, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Enrico Garaci

    1. University of Rome “Tor Vergata”, Rome, Italy

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-xv
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  2. Combination Immunotherapy: Molecular, Cellular, and Gene Approaches

    1. Front Matter

      Pages 1-1
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    2. Combination Therapy with Thymic Hormones and Cytokines after Chemotherapy in Cancer Treatment

      • Enrico Garaci, Cartesio Favalli
      Pages 1-12

    3. Immune Therapy of Human Cancers

      • Robert Peter Gale, Anna Butturini
      Pages 13-17

    4. Use of IL-2 and Lymphocytes Following Bone Marrow Transplantation

      • A. Fefer, C. Higuchi, M. Benyunes, C. Beach, C. Lindgren, C. D. Buckner et al.
      Pages 19-28

    5. COMBO: New Concepts and Methods for Designing and Analyzing Experiments on Combination Therapy

      • John N. Weinstein, Barry Bunow
      Pages 29-38

    6. Combinations of Lymphocyte Activating Agents for Expansion of Tumor Infiltrating Lymphocytes from Renal Cell Carcinoma

      • Gilda G. Hillman, Sudha Sud, Eric J. Dybal, J. Edson Pontes, Gabriel P. Haas
      Pages 39-48

  3. Clinical Applications of Combination Chemoimmunotherapy in Cancer

    1. Front Matter

      Pages 49-49
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    2. IL-2 Based Combination Therapy of Malignant Disease: Summary of the Phase I Experience at the Cleveland Clinic

      • G. T. Budd, S. V. Murthy, J. Finke, R. R. Tubbs, J. Alexander, S. Gautam et al.
      Pages 49-55

    3. The Role of Combination Biologic Therapy in the Immunotherapeutic Approach to the Treatment of Renal Cell Carcinoma

      • Robert A. Figlin, Antoine S. Abi-Aad, Arie Belldegrun, Jean B. deKernion
      Pages 57-65

    4. Maintenance Treatment with Recombinant Interferon Alfa-2b Prolongs Remission and Survival in Patients with Multiple Myeloma Responding to Induction Chemotherapy

      • Franco Dammacco, Giuseppe Avvisati, Mario Boccadoro, Vito Michele Lauta, Rita Di Stefano, Alessandro Pileri et al.
      Pages 67-72

    5. Combination of Fluorouracil and Interferon: Mechanisms of Interaction and Clinical Studies

      • Richard Pazdur
      Pages 73-78

    6. Combination Chemotherapy and Cytokines in the Treatment of Advanced Primary Lung Cancer: Controlled Clinical Trial Three Year Results

      • G. S. Del Giacco, G. Mantovani, V. Arangino, F. Locci, A. C. Scanu, G. Pusceddu
      Pages 79-85

    7. Tumor Immunotherapy with Combined Interleukins Injected Perilymphatically: Experimental and Clinical Findings

      • Cristina Jemma, Stefania Vai, Tiziana Musso, Massimo Geuna, Guido Valente, Guido Forni
      Pages 87-96

  4. Combination Approaches and Gene Therapy in the Treatment of AIDS and Other Infectious Diseases

    1. Front Matter

      Pages 97-97
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    2. Combination Therapies with Cytokines and Anti-Cytokines in Murine Opportunistic Infections

      • Luigina Romani, Simonetta Mocci, Franca Campanile, Paolo Puccetti, Francesco Bistoni
      Pages 97-104

    3. Treatment and Pharmacokinetics of Liposomal-Amphotericin B Patients with Systemic Fungal Infections

      • Gabriel Lopez-Berestein, Michael G. Rosenblum
      Pages 105-112

    4. The Potential Role of Immunomodulation in the Treatment of HIV-Infection and Malignant Diseases

      • Evan M. Hersh, Carole Y. Funk, Eskild A. Petersen
      Pages 113-122

    5. Use of Drugs Targeted to Inhibit Different Stages of the HIV Life Cycle in the Treatment of AIDS

      • Prem S. Sarin, Allan Goldstein, S. Agrawal, Paul Zamecnik
      Pages 123-129

    6. Aspirin as a Biological Response Modifier

      • Judith Hsia, Ting Tang
      Pages 131-137
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Keywords

About this book

Over the past decade many of the key lymphokines, hormones and growth factors that help regulate the immune system have been defined. These molecules, termed biological response modifiers (BRMs) , have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases. Advances in this area have also led to rethinking therapies against a range of autoimmune disorders and other diseases associated with immune and endocrine imbalances. BRMs currently are being applied clinically as both primary and adjunctive therapy to enhance the effectiveness of traditional treatments by maximizing their activities and to protect critical tissues against intolerable chemotherapeutic and radiation damage. Present constraints against the use of BRMs revolve around the nature of these substances in vivo, where many of their actions and the majority of their interactions and synergies remain to be elucidated. For example, as these molecules are thought to exert their effects locally, the systemic administration of lymphokines, cytokines and growth factors at doses adequate to produce a wanted anti-tumor effect in many instances is intolerably toxic. Efforts to overcome this formidable problem have led scientists to begin to explore the transfer of genes known to encode for these molecules into cells which otherwise inadequately elicit or produce anti-tumor or anti-infective responses.

Editors and Affiliations

  • The George Washington University School of Medicine, USA

    Allan L. Goldstein

  • University of Rome “Tor Vergata”, Rome, Italy

    Enrico Garaci

Bibliographic Information

  • Book Title: Combination Therapies

  • Book Subtitle: Biological Response Modifiers in the Treatment of Cancer and Infectious Diseases

  • Editors: Allan L. Goldstein, Enrico Garaci

  • DOI: https://doi.org/10.1007/978-1-4615-3340-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Publishing Corporation 1992

  • Hardcover ISBN: 978-0-306-44115-8Published: 30 April 1992

  • Softcover ISBN: 978-1-4613-6472-6Published: 21 October 2012

  • eBook ISBN: 978-1-4615-3340-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XV, 313

  • Topics: Immunology, Pharmacology/Toxicology

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