Ion Channels

1. Front Matter

   Pages i-xv

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2. Developmental Regulation of Potassium Channels and the Impact on Neuronal Differentiation

   • A. B. Ribera, N. C. Spitzer

   Pages 1-38

3. Voltage-Gated Calcium Channels in Adult Hippocampal Neurons

   • Daniel Johnston, Ronald Fisher, Richard Gray

   Pages 39-62

4. Amino ACID Receptor-Mediated Synaptic Currents in the CA1 Region of the Hippocampus

   • Andy D. Randall, Graham L. Collingridge

   Pages 63-81

5. Intracellular Regulation of GABAA-Receptor Function

   • Armin Stelzer

   Pages 83-136

6. AXON Terminal Hyperexcitability Seen in Epileptogenesis In Vitro

   • Steven F. Stasheff, Wilkie A. Wilson

   Pages 137-157

7. Neural Correlates of Memory Storage

   • C. Collin, D. L. Alkon

   Pages 159-175

8. Functional Regulation of Nicotinic Acetylcholine Receptor Channels in Muscle

   • C. G. Caratsch, F. Grassi, F. Eusebi

   Pages 177-206

9. Rapid Activation and Desensitization of Transmitter-Liganded Receptor Channels by Pulses of Agonists

   • J. Dudel, C. Franke, H. Hatt

   Pages 207-260

10. Neurogenetic Studies of Ion Channels in Drosophila

    • Chun-Fang Wu, Barry Ganetzky

    Pages 261-314

11. Kinetic Properties and Regulation of GABAA Receptor Channels

    • Robert L. Macdonald, Roy E. Twyman

    Pages 315-343

12. Back Matter

    Pages 345-350

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In the past few years, the scientific community has witnessed significant progress in the study of ion channels. Technological advancement in biophysics, molecular biology, and immunology has been greatly ac­ celerated, making it possible to conduct experiments which were deemed very difficult if not impossible in the past. For example, patch-clamp techniques can now be used to measure ionic currents generated by almost every type of cell, thereby allowing us to analyze whole-cell and single­ channel events. It is now possible to incorporate purified ion channel components into lipid bilayers to reconstitute an "excitable membrane." Gene cloning and monoclonal antibody techniques provide us with new approaches to the study of the molecular structure of ion channels. A variety of chemicals have now been found to interact with ion channels. One of the classical examples is represented by tetrodotoxin, a puffer fish poison, which was shown in the early 1960s to block the voltage-activated sodium channel in a highly specific and potent manner.

• Activation
• Drosophila
• axon
• development
• memory
• muscle
• neurons
• receptor
• regulation

• Northwestern University Medical School, Chicago, USA

  Toshio Narahashi

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