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Developmental Patterning of the Vertebrate Limb

  • Book
  • © 1991

Overview

Editors:
  1. J. Richard Hinchliffe

    1. University College of Wales, Aberystwyth, Wales, UK

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  2. Juan M. Hurle

    1. University of Cantabria, Santander, Spain

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    You can also search for this editor in PubMed   Google Scholar

  3. Dennis Summerbell

    1. National Institute for Medical Research, London, UK

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Part of the book series: NATO Science Series A: (NSSA, volume 205)

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Table of contents (54 chapters)

  1. Front Matter

    Pages i-xi
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  2. General Overview

    1. Some Problems in Limb Development

      • Lewis Wolpert
      Pages 1-7

  3. The Molecular Basis of Patterning

    1. Introduction

      1. The Molecular Basis of Limb Patterning: A Review
        • Dennis Summerbell
        Pages 9-14

    2. Pattern of Gene Expression

      1. Expression of the <u>Msh-Like</u> Homebox-Containing Genes during Mouse Limb Development
        • Robert E. Hill, Duncan R. Davidson
        Pages 15-23
      2. The Limb Deformity Gene Encodes Evolutionarily Highly Conserved Proteins
        • Patricia A Blundell, Jose-Luis de la Pompa, J. H. Carel Meijers, Andreas Trumpp, Rolf Zeller
        Pages 25-30
      3. The Role of Homeobox Genes in Amphibian Limb Development and Regeneration
        • Robin Brown, Jeremy P. Brockes
        Pages 31-35
      4. Homeobox-Containing Genes and GAP Junctional Communication in Pattern Formation during Chick Limb Development
        • Robert A. Kosher, William B. Upholt, Caroline N. D. Coelho, Kimberly J. Blake, Lauro Sumoy
        Pages 37-43
      5. Functional Studies of Genes in the Limb
        • Clifford J. Tabin, Bruce Morgan, Hans-Georg Simon, Sara Lazar, Yaoqui Wang, Anuradha Iyer et al.
        Pages 45-54
      6. HOX-7: Temporal Patterns of Expression in Normal and <i>Limbless</i> Chick Embryos
        • G. Lyons, K. Krabbenhoft, B. K. Simandl, M. Buckingham, J. Fallon, B. Robert
        Pages 55-56
      7. Expression Profile of Two Homeoboxgenes during Chicken Embryogenesis
        • Berend von Thülen, Reinhold Janocha, Jürgen Niessing
        Pages 57-59
      8. Characterization of Three Zebrafish Genes Related to Hox-7
        • Marie-Andrée Akimenko, Marc Ekker, Monte Westerfield
        Pages 61-63

    3. Retinoids, Receptors and Gene Expression

      1. A Comparison of the Expression Domains of the Murine Hox-4, RARs and CRABP Genes Suggests Possible Functional Relationships During Patterning of the Vertebrate Limb
        • Pascal Dollé, Esther Ruberte, Juan-Carlos Izpisùa-Belmonte, Hildegard Falkenstein, Pierre Chambon, Denis Duboule
        Pages 65-73
      2. Retinoic Acid Nuclear Receptors
        • P. Kastner, N. Brand, A. Krust, P. Leroy, C. Mendelsohn, M. Petkovich et al.
        Pages 75-88
      3. The Role of Retinoic Acid and Cellular Retinoic Acid-Binding Protein in the Regenerating Amphibian Limb
        • Malcolm Maden, Nick Waterson, Dennis Summerbell, Jean Maignon, Michel Darmon, Braham Shroot
        Pages 89-96
      4. Retinoic Acid Treatment Alters the Pattern of Retinoic Acid Receptor Beta Expression in the Embryonic Chick Limb
        • Annie Rowe, Joy M. Richman, James O. Ochanda, Paul M. Brickell
        Pages 97-100
      5. Expression Pattern of an RXR Nuclear Receptor Gene in the Chick Embryo
        • Annie Rowe, Nicholas S. C. Eager, Melanie Saville, Lewis Wolpert, Paul M. Brickell
        Pages 101-104

    4. Growth and Pattern, Retinoids and Other Factors

      1. Retinoic Acid and Limb Pattern Formation in Cell Culture
        • Hiroyuki Ide, Yasushi Ohkubo, Sumihare Noji, Shigehiko Taniguchi
        Pages 105-113
      2. Growth Factors Produced by the Polarising Zone — A Complement to the Retinoic Acid System
        • John C. McLachlan
        Pages 115-122
      3. Biochemical and Molecular Aspects of Retinoid Action in Limb Pattern Formation
        • Reinhold Janocha, Gregor Eichele
        Pages 123-132
      4. Position-Dependent Properties of Limb Cells
        • S. V. Bryant, T. Hayamizu, N. Wanek, D. M. Gardiner
        Pages 133-142
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Keywords

About this book

Following pioneering work by Harrison on amphibian limbs in the 1920s and by Saunders (1948) on the apical ridge in chick limbs, limb development became a classical model system for investigating such fundamental developmental issues as tissue interactions and induction, and the control of pattern formation. Earlier international conferences, at Grenoble 1972, Glasgow 1976,and Storrs, Connecticut 1982, reflected the interests and technology of their time. Grenoble was concerned with ectoderm-mesenchyme interaction, but by the time of the Glasgow meeting, the zone of polarizing activity (ZPA) and its role in control of patterning was the dominant theme. Storrs produced the first intimations that the ZPA could be mimicked by retinoic acid (RA), but the diversity of extracellular masrix ~olecules,particularly in skeletogenesis,was the main focus of attention. By 1990, the paradigms had again shifted. Originally, the planners of the ARW saw retinoic acid (as a possible morphogen controlling skeletal patterning), the variety of extracellular matrix components and their roles, and the developmental basis of limb evolution as the leading contemporary topics. However, as planning proceeded, it was clear that the new results emerging from the use of homeobox gene probes (first developed to investigate the genetic control of patterning of Drosophila embryos) to analyse the localised expression of "patterning genes" in limb buds would also be an important theme.

Editors and Affiliations

  • University College of Wales, Aberystwyth, Wales, UK

    J. Richard Hinchliffe

  • University of Cantabria, Santander, Spain

    Juan M. Hurle

  • National Institute for Medical Research, London, UK

    Dennis Summerbell

Bibliographic Information

  • Book Title: Developmental Patterning of the Vertebrate Limb

  • Editors: J. Richard Hinchliffe, Juan M. Hurle, Dennis Summerbell

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4615-3310-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1991

  • Hardcover ISBN: 978-0-306-43927-8Published: 30 November 1991

  • Softcover ISBN: 978-1-4613-6457-3Published: 29 October 2012

  • eBook ISBN: 978-1-4615-3310-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 452

  • Topics: Developmental Biology, Human Genetics, Animal Anatomy / Morphology / Histology, Plant Sciences

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