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Growth Factors and the Cardiovascular System

  • Book
  • © 1993

Overview

Editors:
  1. Peter Cummins

    1. Department of Physiology, University of Birmingham School of Medicine, Birmingham, UK

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 147)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Growth factors: In vivo function and mechanism of action

    • Carl-Henrik Heldin, Lena Claesson-Welsh, Kohei Miyazono, Bengt Westermark
    Pages 1-15

  3. Fibroblast and transforming growth factors in the heart: A role in cardiac growth ?

    • Peter Cummins, Abdel-Ilah K. El Amrani, Francine El Amrani
    Pages 17-30

  4. Growth factors and the cardiac extra-cellular matrix

    • Lydie Rappaport, Jane Lise Samuel
    Pages 31-43

  5. Transforming growth factor-ß: localization and possible functional roles in cardiac myocytes

    • Anita B. Roberts, Michael B. Sporn
    Pages 45-53

  6. Basic fibroblast growth factor in cardiac myocytes: expression and effects

    • Elissavet Kardami, Raymond R. Padua, Kishore Babu S. Pasumarthi, Lei Liu, Bradley W. Doble, Sarah E. Davey et al.
    Pages 55-75

  7. Growth factor signal transduction in the cardiac myocyte: functions of the serum response element

    • Michael D. Schneider, Thomas Brand, Robert J. Schwartz, W. Robb MacLellan
    Pages 77-103

  8. Effects of growth factors on human cardiac myocytes

    • Bruce I. Goldman, John Wurzel
    Pages 105-117

  9. Growth factors and development of coronary collaterals

    • Hari S. Sharma, Rene Zimmerman
    Pages 119-148

  10. The role of growth factors in angiogenesis

    • Robert J. Schott, Linda A. Morrow
    Pages 149-168

  11. Atherosclerosis and platelet derived growth factors

    • Gordon A. A. Ferns, Claire Rutherford
    Pages 169-187

  12. Effects of TGF-ß on vascular smooth muscle cell growth

    • Peter L. Weissberg, D. J. Grainger, James C. Metcalfe
    Pages 189-206

  13. Some aspects of growth signal transduction in vascular smooth muscle cells

    • Andrew C. Newby, Nicholas P. J. Brindle
    Pages 207-225

  14. Basic FGF’s role in smooth muscle cell proliferation: A basis for molecular atherectomy

    • Ward Casscells, Douglas A. Lappi, Andrew Baird
    Pages 227-248

  15. Role of transforming growth factor ß in cardioprotection of the ischemic-reperfused myocardium

    • Allan M. Lefer
    Pages 249-260

  16. Platelet-derived growth factor release after angioplasty

    • P. Macke Consigny
    Pages 261-274

  17. Platelet-derived growth factor (PDGF) receptor induced by vascular injury

    • Glenda E. Bilder
    Pages 275-285

  18. Growth factors and hypertension: Implications for a role in vascular remodelling

    • Abdel-Ilah K. El Amrani, Francine El Amrani, Peter Cummins
    Pages 287-310

  19. Transforming growth factor-ß induction in carcinoid heart disease

    • Johannes Waltenberger
    Pages 311-320

  20. Adrenergic stimulation and growth factor activity

    • Carlin S. Long, Paul C. Simpson
    Pages 321-335
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Keywords

About this book

Nature is totally amoral! There are at least 3-4 million people in France alone who suffer from arterial hypertension, and whose cardiovascular system is submitted day and night to both a haemodynamic and hormonal stress. In all cases, the vasculature hypertrophies as does the myocardium. This growth process is obviously mainly detrimental at the outset since it lowers compliance of the arteries and makes them stiffer. In contrast, myocardial hypertrophy is initially beneficial since the growth process multiplies the number of contractile units and by so doing improves external work. In addition, according to Starling's law, wall stress is lowered. Growth factors playa major role in this amoral process as a trigger for hypertrophy at the vascular level, and very likely at the level of the myocardium. Another major point of interest is the role of growth factors as determinants of restenosis after angioplasty and also of atherogenesis. Several chapters in this book are directly or indirectly concerned with this problem which is far from being purely academic since several groups are currently trying to control these processes by gene transfer. Certainly, one of the major clinical questions arising from such studies is why restenosis is not more frequent in clinical practice. After de-endotheliazation, the biologist would predict on the basis of recent studies on growth factors, and in contrast with current clinical opinion, that hypertrophy would occur in all cases with more or less complete restenosis.

Editors and Affiliations

  • Department of Physiology, University of Birmingham School of Medicine, Birmingham, UK

    Peter Cummins

Bibliographic Information

  • Book Title: Growth Factors and the Cardiovascular System

  • Editors: Peter Cummins

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4615-3098-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1993

  • Hardcover ISBN: 978-0-7923-2401-0Published: 31 August 1993

  • Softcover ISBN: 978-1-4613-6354-5Published: 08 October 2012

  • eBook ISBN: 978-1-4615-3098-5Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XVII, 370

  • Topics: Cardiology, Medicine/Public Health, general

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