Skip to main content
SpringerLink
Log in

Oncogenes and Tumor Suppressor Genes in Human Malignancies

  • Book
  • © 1993

Overview

Editors:
  1. Christopher C. Benz

    1. Cancer Research Institute, University of California, San Francisco, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Edison T. Liu

    1. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Cancer Treatment and Research (CTAR, volume 63)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvii
    Download chapter PDF

  2. Oncogenes and tumor suppressor genes

    • Edison Liu, Bernard Weissman
    Pages 1-13

  3. Activated oncogenes and putative tumor suppressor genes involved in human breast cancers

    • Debasish Tripathy, Christopher C. Benz
    Pages 15-60

  4. Oncogenes in human lung cancer

    • Robert A. Kratzke, Eiji Shimizu, Frederic J. Kaye
    Pages 61-85

  5. Thyroid growth factors and oncogenes

    • Orlo H. Clark, Quan-Yang Duh
    Pages 87-104

  6. Growth regulation of human neuroblastoma

    • Osama M. El-Badry, Mark A. Israel
    Pages 105-128

  7. Kaposi sarcoma: A cytokine-responsive neoplasia?

    • Steven A. Miles
    Pages 129-140

  8. BCL-2: Physiology and role in neoplasia

    • Adam Bagg, Jeffrey Cossman
    Pages 141-166

  9. Malignant transformation by abl and BCR/ABL

    • Richard A. Van Etten
    Pages 167-192

  10. The biological and clinical roles of increased insulin receptors in human breast cancer

    • Riccardo Vigneri, Ira D. Goldfine
    Pages 193-209

  11. The role of fibroblast growth factors and related oncogenes in tumor growth

    • Harold Brem, Michael Klagsbrun
    Pages 211-231

  12. Transforming growth factor-alpha and its role in neoplastic progression

    • David C. Lee, Noreen C. Luetteke, Leslie A. Petch
    Pages 233-254

  13. Growth regulation by transforming growth factor-β

    • Bradley A. Arrick, Rik Derynck
    Pages 255-264

  14. Signal transduction by receptor tyrosine kinases

    • David R. Kaplan, Archibald Perkins, Deborah K. Morrison
    Pages 265-279

  15. Involvement of G proteins, cytoplasmic calcium, phospholipases, phospholipid-derived second messengers, and protein kinases in signal transduction from mitogenic cell surface receptors

    • Roy A. Frye
    Pages 281-299

  16. Fos and Jun: Inducible transcription factors regulating growth of normal and transformed cells

    • Jeffrey Holt
    Pages 301-311

  17. DNA binding by the Myc oncoproteins

    • Gregory J. Kato, Daniel S. Wechsler, Chi V. Dang
    Pages 313-325

  18. Normal and malignant growth control by p53

    • Cathy A. Finlay
    Pages 327-344

  19. Nucleoside diphosphate kinases, nm23, and tumor metastasis: Possible biochemical mechanisms

    • Adam Golden, Mary Benedict, Allen Shearn, Narimichi Kimura, Alvaro Leone, Lance A. Liotta et al.
    Pages 345-358

  20. Angiogenesis: A mechanism by which oncogenes and tumor suppressor genes regulate tumorigenesis

    • Noël Bouck
    Pages 359-371
Back to top

Keywords

About this book

The first edition of Oncogenes (1989) focused on several of the better known transforming mechanisms and surveyed a spectrum of solid tumors and hematologic malignancies. Several of the nearly 50 known oncogenes most relevant to human disease were examined. In contrast, this volume presents a very different profile and balance of subject material that reflects the rapidly changing field of molecular oncology and its newly emerging concepts. Among the most important discoveries of the past 4 years are the identification of nearly a dozen different tumor suppressor genes and the finding of an entirely new class of cancer-causing gene (bcl-2) that acts by inhibiting cell death rather than stimulating cell proliferation. This edition begins by reviewing selected malignancies in which our earlier search for clinically relevant oncogenes has led to more focused studies on gain-of-function and loss-of-function genetic abnormalities, as well as autocrine and paracrine growth factor loops known to regulate tumor physiology and malignant cell behavior. Curiously, many of these genetic and functional abnormalities are shared by several different tumor types and are not uniformly present in all tumors of the same type. This observation brings up molecular questions about the tissue-specific determinants that underlie individual cancers and also gives added impetus to the suggestion that molecular abnormalities (referred to as tumor markers) be included among the histopathologic features used for clinical diagnosis and manage­ ment.

Editors and Affiliations

  • Cancer Research Institute, University of California, San Francisco, USA

    Christopher C. Benz

  • Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison T. Liu

Bibliographic Information

  • Book Title: Oncogenes and Tumor Suppressor Genes in Human Malignancies

  • Editors: Christopher C. Benz, Edison T. Liu

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-1-4615-3088-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1993

  • Hardcover ISBN: 978-0-7923-1960-3Published: 28 February 1993

  • Softcover ISBN: 978-1-4613-6349-1Published: 21 October 2012

  • eBook ISBN: 978-1-4615-3088-6Published: 06 December 2012

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: XVII, 382

  • Topics: Oncology, Cancer Research

Publish with us

Policies and ethics

Back to top

Search

Navigation