Cellular Function and Metabolism

1. Front Matter

   Pages i-1

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2. Control of Growth in Neonatal Pig Hearts

   • Cathy J. Beinlich, Howard E. Morgan

   Pages 3-9

3. Role of Protein Kinase System in the Signal Transduction of Stretch-Mediated Protooncogene Expression and Hypertrophy of Cardiac Myocytes

   • Yoshio Yazaki, Issei Komuro, Tsutomu Yamazaki, Kazuyuki Tobe, Kouji Maemura, Takashi Kadowaki et al.

   Pages 11-16

4. Growth Factor for Cardiac Hypertrophy

   • Makoto Nagano, Tadanari Ohkubo, Tohru Arino, Masahito Tsuchiya, Makoto Nagai

   Pages 17-22

5. Effect of Angiotensin Coverting Enzyme Inhibitor on Regression in Cardiac Hypertrophy

   • Naoki Makino, Hirosuke Matsui, Kazuhiro Masutomo, Tomoji Hata, Takashi Yanaga

   Pages 23-28

6. Differing Responses of G2-Related Genes During Differentiation of HL60 Cells Induced by TPA or DMSO

   • Junko Horiguchi-Yamada, Hisashi Yamada

   Pages 29-34

7. Mechanistic Effects of Kijimicin on Inhibition of Human Immunodeficiency Virus Replication

   • Teruo Yamauchi, Mariko Nakamura, Hitoshi Honma, Motoaki Ikeda, Kazunari Kawashima, Tsuneya Ohno

   Pages 35-41

8. Function and Energy Metabolism of Isolated Hearts Obtained from Hyperthyroid Spontaneously Hypertensive Rats (SHR) A 31P-Nuclear Magnetic Resonance Study

   • M. Heckmann, S. Lortet, J. Aussedat, A. Ray, A. Rossi, H. G. Zimmer

   Pages 43-50

9. Increased Calcium Release from Sarcoplasmic Reticulum Stimulated by Inositol Trisphosphate in Spontaneously Hypertensive Rat Heart Cells

   • Hideaki Kawaguchi, Hitoshi Sano, Hitoshi Okada, Kenji Iizuka, Hiroshi Okamoto, Toshiyuki Kudo et al.

   Pages 51-57

10. Radial Spread of Aequorin Ca2+ Signal in Single Frog Skeletal Muscle Fibers

    • Masato Konishi, Satoshi Kurihara

    Pages 59-66

11. Cardiac Contractile Proteins and Autoimmune Myocarditis

    • Tohru Izumi, Haruo Hanawa, Makihiko Saeki, Makoto Kodama

    Pages 67-71

12. Force-Frequency-Relation in Human Atrial and Ventricular Myocardium

    • Robert H. G. Schwinger, Michael Böhm, Andrea Koch, Rainer Uhlmann, Peter Überfuhr, Eckhart Kreuzer et al.

    Pages 73-78

13. Depressed Sliding Velocity of Isolated Cardiac Myosin from Cardiomyopathic Hamsters: Evidence for an Alteration in Mechanical Interaction of Actomyosin

    • Hiroshi Yamashita, Seiryo Sugiura, Masataka Sata, Takashi Serizawa, Masahiko Iizuka, Teruo Shimmen et al.

    Pages 79-88

14. Abnormalities of ADP/ATP Carrier Protein in J-2-N Cardiomyopathic Hamsters

    • Mitsutoshi Kato, Jie Yang, Takaaki Iwai, Akira Tanamura, Toru Arino, Osamu Kawashima et al.

    Pages 89-94

15. Age-Associated Damage in Mitochondrial DNA in Human Hearts

    • Mika Hayakawa, Satoru Sugiyama, Kazuki Hattori, Masaaki Takasawa, Takayuki Ozawa

    Pages 95-103

16. Mitochondrial DNA Deletion in Human Myocardium

    • Nobuakira Takeda, Akira Tanamura, Takaaki Iwai, Izuru Nakamura, Mitsutoshi Kato, Tadanari Ohkubo et al.

    Pages 105-108

17. Ischemic changes in myocardial ionic eontents of the isolated perfused rat hearts as studied by NMR

    • Takaharu Ishibashi, Mikio Nakazawa, Shoichi Imai

    Pages 109-120

18. 31P-NMR magnetization transfer study of reperfused rat heart

    • Akira Kobayashi, Yoshimi Okayama, Noboru Yamazaki

    Pages 121-127

19. Release of 6-KET0-PGFlα and thromboxane B2 in late appearing cardioprotection induced by the stable PGI analogue: 7-OXO-PGI

    • László Szekeres, Árpád Tósaki

    Pages 129-132

20. Effects of Iloprost, a PGI2 Derivative, on Ischemic Myocardial Energy and Carbohydrate Metabolism in Dogs

    • Kazuo Ichihara, Kiminobu Yamamoto, Yasushi Abiko

    Pages 133-141

A variety of metabolic processes are known to be intimately involved in the maintenance of cellular structure and function. It has also become clear that metabolic events involved in the synthesis and hydrolysis of ATP as well as for the synthesis of proteins and phospholipids are essential for cellular health. The regulation of cell function is generally achieved through participation of a wide variety of hormones and different signal transduction mechanisms for the activation/deactivation of some specific metabolic processes. In this regard cyclic AMP and calcium seem to play a crucial role. Various hormones are also known to affect the genetic machinery of all the cell; however, the exact signals for genetic control of cellular function are not well defined. In particular, the sequence of events concerned with remodelling of different types of cells under various pathological situations is poorly understood. In this book we have therefore dealt with some of these issues from biochemical, molecular biological, physiological, and pharmacological viewpoints. Special emphasis has been laid on understanding heart function and metabolism in health and disease in general, and cardiac hypertrophy, heart failure, and ischemic heart disease in particular. It is hoped that this multidisciplinary information will be of value to basic scientists and clinical investigators.

• ATP
• Activation
• Calcium
• DNA
• Hamster
• Regulation
• enzymes
• gene expression
• metabolism
• proteins

• Third Department of Internal Medicine Faculty of Medicine, University of Tokyo, Tokyo 113, Japan

  Yoshio Yazaki

• Department of Internal Medicine, Jikei University School of Medicine, Tokyo 125, Japan

  Seibu Mochizuki

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