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Mechanisms of Platelet Activation and Control

  • Book
  • © 1993

Overview

Editors:
  1. Kalwant S. Authi

    1. Thrombosis Research Institute, London, UK

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  2. Steve P. Watson

    1. University of Oxford, Oxford, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. Vijay V. Kakkar

    1. Thrombosis Research Institute, London, UK

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 344)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. The Platelet as a Cа2+-Driven Cell: Mechanisms Which May Modulate Cа2+-Driven Responses

    • Michael C. Scrutton
    Pages 1-15

  3. Agonist Receptors and G proteins as Mediators of Platelet Activation

    • Lawrence F. Brass, James A. Hoxie, Thomas Kieber-Emmons, David R. Manning, Mortimer Poncz, Marilyn Woolkalis
    Pages 17-36

  4. Regulation of Phosphoinositide-Specific Phospholipase C Activity in Human Platelets

    • Yoshinori Nozawa, Yoshiko Banno, Koh-ichi Nagata
    Pages 37-47

  5. RAP1B and Platelet Function

    • Eduardo G. Lapetina, Francis X. Farrell
    Pages 49-55

  6. Calcium Signalling and Phosphoinositide Metabolism in Platelets: Subsecond Events Revealed by Quenched-Flow Techniques

    • Adrian R. L. Gear, Sanghamitra Raha
    Pages 57-67

  7. Calcium Influx Mechanisms and Signal Organisation in Human Platelets

    • Stewart O. Sage, Paul Sargeant, Johan W. M. Heemskerk, Martyn P. Mahaut-Smith
    Pages 69-82

  8. Ca2+ Homeostasis and Intracellular Pools in Human Platelets

    • Kalwant S. Authi
    Pages 83-104

  9. The Use of Inhibitors of Protein Kinases and Protein Phosphatases to Investigate the Role of Protein Phоsphorylation in Platelet Activation

    • Steve P. Watson, Robert A. Blake, Trevor Lane, Trevor R. Walker
    Pages 105-118

  10. Serine/Тhrеonine Kinases in Signal Transduction in Response to Thrombin in Human Platelets Use of 17—Hydroxywortmannin to Discriminate Signals

    • Kenneth J. Clemetson, Markus Kocher, Vinzenz von Tscharner
    Pages 119-128

  11. Tyrosine Phosphorylation in Platelets: Its Regulation and Possible Roles in Platelet Functions

    • Maurice B. Feinstein, Kevin Pumiglia, Lit-Fui Lau
    Pages 129-148

  12. Evidence That Activation of Phospholipase D can Mediate Secretion from Permeabilized Platelets

    • Richard J. Haslam, Jens R. Coorssen
    Pages 149-164

  13. Inositol Lipid Metabolism, the Cytoskeleton, Glycoprotein IIb IIIa and Platelets

    • Gérard P. Mauco, Claire Sultan, Bernard Payrastre, Monique Plantavid, Monique Breton, Hugues Chap
    Pages 165-174

  14. Regulation of Platelet Function by the Cytoskeleton

    • Joan E. B. Fox
    Pages 175-185

  15. Cytoskeletal Interactions of Raplb in Platelets

    • Gilbert C. White II, Neville Crawford, Thomas H. Fischer
    Pages 187-194

  16. Mechanisms Involved in Platelet Procoagulant Response

    • Edouard M. Bevers, Paul Comfurius, Robert F. A. Zwaal
    Pages 195-207

  17. Histamine as an Intracellular Messenger in Human Platelets

    • J. M. Gerrard, S. P. Saxena, A. McNicol
    Pages 209-219

  18. Platelet Activation Via Binding of Monoclonal Antibodies to the Fcγ Receptor II

    • J. Michael Wilkinson, Edward J. Hornby, Kalwant S. Authi
    Pages 221-228

  19. Functional Relationship between Cyclic AMP-Dependent Protein Рhosphorylation and Platelet Inhibition

    • Wolfgang Siess, Bernd Grünberg, Karin Luber
    Pages 229-235

  20. Role of Cyclic Nucleotide-Dependent Protein Kinases and Their Common Substrate VASP in the Regulation of Human Platelets

    • Ulrich Walter, Martin Eigenthaler, Jörg Geiger, Matthias Reinhard
    Pages 237-249
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Keywords

About this book

Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction in platelets from the identification of surface receptors, G proteins, phospholipases, protein kinases and phosphatases, intracellular receptors for inositol phosphates, the Ca2+ regulatory machinery, cytoskeletal constituents to the control mechanism employing cyclic nucleotides has seen an explosion of information regarding their importance and for each constituent in the family of molecules to which they belong. This information has been of interest to researchers across a wide spectrum of disciplines including biochemists, pharmacologists, cell biologists and clinicians. In April 1992 an International Symposium bearing the name of this volume was organised at the Thrombosis Research Institute to bring together scientists from across the world whose common interest was the study of platelet activation and its regulation. We were particularly encouraged by the positive response from our speakers and the participants, their detailed contributions and the very lively discussions that took place throughout the two days of the symposium. Almost every aspect of signal transduction in human platelets was represented. Of the invited speakers twelve were from Europe (including the U. K. ), eight from North America and one from Japan. This volume is a compilation of chapters submitted by the speakers and represents a concise but informative picture of the present knowledge of the mechanisms of platelet activation and control.

Editors and Affiliations

  • Thrombosis Research Institute, London, UK

    Kalwant S. Authi, Vijay V. Kakkar

  • University of Oxford, Oxford, UK

    Steve P. Watson

Bibliographic Information

  • Book Title: Mechanisms of Platelet Activation and Control

  • Editors: Kalwant S. Authi, Steve P. Watson, Vijay V. Kakkar

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-2994-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1993

  • Hardcover ISBN: 978-0-306-44631-3Published: 28 February 1994

  • Softcover ISBN: 978-1-4613-6304-0Published: 05 November 2012

  • eBook ISBN: 978-1-4615-2994-1Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 272

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Animal Anatomy / Morphology / Histology, Plant Sciences

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