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Current Directions in Insulin-Like Growth Factor Research

  • Book
  • © 1993

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Editors:
  1. Derek Roith

    1. National Institutes of Health, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Mohan K. Raizada

    1. University of Florida, Gainesville, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 343)

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Table of contents (38 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Structure, Expression, and Regulation of the IGF-I Gene

    • Martin L. Adamo, Stefan Neuenschwander, Derek LeRoith, Charles T. Roberts Jr.
    Pages 1-11

  3. Differential Regulation of IGF-I Leader Exon Transcription

    • Jennifer M. Pell, R. Stewart Gilmour
    Pages 13-23

  4. Insulin and IGF-I Analogs: Novel Approaches to Improved Insulin Pharmacokinetics

    • Lawrence J. Slieker, Gerald S. Brooke, Ronald E. Chance, Li Fan, James A. Hoffmann, Daniel C. Howey et al.
    Pages 25-32

  5. Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins

    • Margaret A. Cascieri, Marvin L. Bayne
    Pages 33-40

  6. Synthesis and Characterization of IGF-II Analogs: Applications in the Evaluation of IGF Receptor Function and IGF-Independent Actions of IGFBPS

    • Youngman Oh, Hermann L. Müller, Heping Zhang, Nicholas Ling, Ron G. Rosenfeld
    Pages 41-54

  7. Towards Identification of a Binding Site on Insulin-Like Growth Factor-II for IGF-Binding Proteins

    • Leon A. Bach, Susan Hsieh, Katsu-ichi Sakano, Hiroyuki Fujiwara, James F. Perdue, Matthew M. Rechler
    Pages 55-61

  8. Transcriptional and Post-Transcriptional Regulation of the Human IGF-II Gene Expression

    • J. S. Sussenbach, R. J. T. Rodenburg, W. Scheper, P. Holthuizen
    Pages 63-71

  9. Significant Species Differences in Local IGF-I and -II Gene Expression

    • Carolyn A. Bondy, Edward Chin, Jian Zhou
    Pages 73-77

  10. Transcriptional Regulation of the Insulin Receptor Gene Promoter

    • Catherine McKeon
    Pages 79-89

  11. The Regulation of IGF-I Receptor Gene Expression by Positive and Negative Zinc-Finger Transcription Factors

    • Haim Werner, Charles T. Roberts Jr., Derek LeRoith
    Pages 91-103

  12. Cell Cycle Control by the IGF-1 Receptor and Its Ligands

    • Renato Baserga, Pierluigi Porcu, Michele Rubini, Christian Sell
    Pages 105-112

  13. The Insulin Receptor Family

    • Karen A. Seta, Kristina S. Kovacina, Richard A. Roth
    Pages 113-124

  14. IRR: A Novel Member of the Insulin Receptor Family

    • Valerie M. Watt, Peter Shier, Joanne Chan, Bradley A. Petrisor, Swarna K. Mathi
    Pages 125-132

  15. Molecular Properties of Insulin/IGF-1 Hybrid Receptors 4th International Symposium on Insulin, IGFs and Their Receptors

    • Jeffrey E. Pessin
    Pages 133-144

  16. Immunological Studies of Type I IGF Receptors and Insulin Receptors: Characterisation of Hybrid and Atypical Receptor Subtypes

    • Maria A. Soos, Barbara T. Navé, Kenneth Siddle
    Pages 145-157

  17. Insulin Like Growth Factor 1 Receptor Signal Transduction to the Nucleus

    • Steven A. Rosenzweig, Barry S. Oemar, Norman M. Law, Uma T. Shankavaram, Bradley S. Miller
    Pages 159-168

  18. Molecular Cloning of pp120/ ECTO-ATPase, An Endogenous Substrate of the Insulin Receptor Kinase

    • Sonia M. Najjar, Neubert Philippe, Simeon I. Taylor, Domenico Accili
    Pages 169-174

  19. The Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor: Structure, Function and Differential Expression

    • Wieland Kiess, Andreas Hoeflich, Yi Yang, Ulrike Kessler, Allan Flyvbjerg, Bruno Barenton
    Pages 175-188

  20. Parental Imprinting of the Genes for IGF-II and Its Receptor

    • Constantin Polychronakos
    Pages 189-203
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Keywords

About this book

The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Initially, this family consisted of ligands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, there are now more potential receptors when one considers the possible roles of the insulin-receptor related receptor (IRR) and hybrid receptor dimers composed of insulin and IGF-I receptor (half-receptors). Another important aspect of this area of research is the realization that the IGFs are not only essential for normal growth and development but, in addition play an important role in the normal specialized function(s) of all tissues of the body, including the nervous system, skeleton, reproductive system, kidney, and the immune system, to name but a few. The development of recombi!tant human IGF-I for clinical testing has been a major breakthrough for investigators. Potential uses include wound healing, reversal of catabolic states, diabetes, bone remodeling, recovery from acute renal failure and many others. will determine both its use and its potential hazards.

Editors and Affiliations

  • National Institutes of Health, Bethesda, USA

    Derek Roith

  • University of Florida, Gainesville, USA

    Mohan K. Raizada

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