Advances in Neutron Capture Therapy

1. Front Matter

   Pages i-xxx

   PDF

2. Review of Reactor-Based Neutron Beam Development for Bnct Applications

   • R. L. Moss

   Pages 1-7

3. Evaluation of Neutron Irradiation Fields for Bnct by Using Absorbed Dose in a Phantom

   • O. Aizawa

   Pages 9-13

4. Analysis of Filtered Neutron Beams At Hifar

   • Baiba V. Harrington, Geoffrey Constantine

   Pages 15-20

5. Filtered Neutron Beam Measurements at Hifar

   • M Carolan, G Constantine, R Godfrey, H Meriaty, G Storr, B J Allen

   Pages 21-24

6. Preclinical Tests for Neutron Capture Therapy on the Lvr-15 Reactor

   • J. Burian, M. Marek, J Rataj, V. Mares, P. Stopka, O. Strouf

   Pages 25-28

7. Study on Remodeling the Heavy Water Facility of the Kyoto University Reactor for Neutron Capture Therapy from the Concept of Neutron Energy Spectrum Control

   • Tooru Kobayashi, Yoshinori Sakurai, Keiji Kanda

   Pages 29-32

8. Improvement of Thermal Neutron Fluence for Bnct Treatment of Deep—Seated Tumors: Simulation Calculation and Phantom Experiments

   • Yoshinori Sakurai, Tooru Kobayashi, Koichi Ono, Takashi Sato, Keiji Kanda

   Pages 33-36

9. The Sensitivity of Research Reactor Based Bnct Irradiation Facility Performance to Core Conversion from High to Low Enriched Uranium Fuels

   • Lisa A. Heimberger, Tunc Aldemir

   Pages 37-41

10. Neutron Spectrum Determination for the Boron Neutron Capture Therapy Program in Thailand

    • T. Vilaithong, W. Hoffmann, G. Hoyes, S. Dangtip, S. Singkarat, P. Suanpoot

    Pages 43-46

11. A Standardized Method for Beam Design in Neutron Capture Therapy

    • Gregory J. Storr, Baiba V. Harrington

    Pages 47-51

12. Application of Fricke Dosimetry for Bnct

    • Bartlomiej Ciesielski, Lucian Wielopolski

    Pages 53-57

13. Nuclear Characterisation of the Hfr Petten Bnct Facility

    • P. Watkins, Y. Harker, C. Amaro, W. Voorbraak, F. Stecher-Rasmussen, H. Verhagen et al.

    Pages 59-65

14. A Comparison of Epithermal Neutron Beams for Nct: Effect of Beam Collimation on Therapy Parameters

    • J. C. Yanch, O. K. Harling

    Pages 67-70

15. Physics Parameters for an Epithermal—Neutron Beam at the Georgia Institute of Technology

    • David W. Nigg, Gregory J. Storr, Floyd J. Wheeler

    Pages 71-74

16. Enhancement of the Epithermal Neutron Beam at the Brookhaven Medical Research Reactor

    • Hungyuan B. Liu, Robert M. Brugger, David C. Rorer

    Pages 75-79

17. Epithermal BNCT Neutron Beam Design for a Triga II Reactor

    • Iiro Auterinen, Pekka Hiismäki

    Pages 81-84

18. Generating Epithermal Neutron Beams for Neutron Capture Therapy in Small Reactors

    • H. Rief, R. Van Heusden, G. Perlini

    Pages 85-88

19. Epithermal and Fast Neutron Spectrum Measurement at the Brookhaven Medical Research Reactor (Bmrr)

    • Gad Shani

    Pages 89-93

20. Accelerator-Based Epithermal Neutron Beams for Neutron Capture Therapy

    • J. C. Yanch, R. E. Shefer, B. J. Hughey, R. E. Klinkowstein

    Pages 95-98

Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non­ ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.

• Amino acid
• Nucleoside
• Nucleotide
• Tumor
• reaction
• Ultrasonography

• The Ohio State University, Columbus, USA

  Albert H. Soloway, Rolf F. Barth, David E. Carpenter

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