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Chemistry and Biology of Pteridines and Folates

  • Book
  • © 1993

Overview

Editors:
  1. June E. Ayling

    1. Dept of Pharmacology College of Medicine, Universily of South Alabama, Mobile, USA

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  2. M. Gopal Nair

    1. Dept. of Biochemistry College of Medicine, University of South Alabama, Mobile, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Charles M. Baugh

    1. College of Medicine, Universily of South Alabama, Mobile, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 338)

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Table of contents (165 chapters)

  1. Front Matter

    Pages i-xxvi
    Download chapter PDF

  2. Chemistry

    1. Natural Pteridines -A Chemical Hobby

      • Wolfgang Pfleiderer
      Pages 1-16

    2. Properties and Reactions of Pteridines Carrying Functionalised Side Chains at the 3-Position

      • Peter Boyle, Russell Camier
      Pages 17-20

    3. N 2-(N,N-Dimethylaminomethylene)-O 4-(2-p-Nitrophenyl. Ethyl)-Biopterin: A Versatile Intermediate for a Glycosidation Reaction

      • Hiroshi Yamamoto, Tadashi Hanaya, Kiyoshi Torigoe, Wolfgang Pfleiderer
      Pages 21-24

    4. The Synthesis of Fluorine-Containing Pterins

      • Caroline Dunn, Colin L. Gibson, Colin J. Suckling, Weifan Xing
      Pages 25-28

    5. Formation of FeIII or FeII Complexes with Acetylaceto-Nate and 5,6,7,8-Tetrahydropterin as Ligands and Their Activation of Oxygen

      • Andrea Schäfer, Berthold Fischer, René Bosshard, Manfred Hesse, Max Viscontini
      Pages 29-32

    6. Stereoelectronic Effects in the Autoxidative Destruction of Reduced Folate Derivatives

      • Anthony L. Fitzhugh
      Pages 33-37

    7. Mindo/3 Molecular-Orbital Calculations on the 6R-BH4 Molecule and Its Metabolic Precursors : Conformation and Activity

      • Setsuko Katoh, Terumi Sueoka, Teruo Kurihara
      Pages 39-42

    8. Identification, Stereoconfiguration, Chromatographic and Fluorescence Properties of Natural Pterins

      • Roger Klein
      Pages 43-46

  3. Tetrahydrobiopterin Dependent Hydroxylases

    1. The Mechanism of Cofactor Regeneration During Phenylalanine Hydroxylation

      • Steven W. Bailey, Scott R. Boerth, Shirley B. Dillard, June E. Ayling
      Pages 47-54

    2. Structure Function Studies of the Phenylalanine Hydroxylase Active Site and a Summary of Structural Features

      • R. G. H. Cotton, D. W. Howells, J. A. Saleeba, I. Dianzani, P. M. Smooker, I. G. Jennings
      Pages 55-57

    3. Expression of Wild Type and Mutant Forms of Human Phenylalanine Hydroxylase in E. Coli

      • Per M. Knappskog, Hans G. Eiken, Aurora Martinez, Sigridur Olafsdottir, Jan Haavik, Torgeir Flatmark et al.
      Pages 59-62

    4. A Re-Examination of the Metal Requirement of Chromobacterium Violaceum Phenylalanine Hydroxylase

      • Robert T. Carr, Stephen J. Benkovic
      Pages 63-66

    5. Histidines 138 and 143 are Copper Binding Ligands in Chromobacterium Violaceum Phenylalanine Hydroxylase

      • Shankar Balasubramanian, Robert T. Carr, Christopher J. Bender, Jack Peisach, Stephen J. Benkovic
      Pages 67-70

    6. Characterization of the Iron Environment in Recombinant Human Tyrosine Hydroxylase, Using Mössbauer and EPR-Spectroscopy

      • Jan Haavik, Eckhard Bill, Marek Lengen, Aurora Martìnez, Torgeir Flatmark, Alfred X. Trautwein
      Pages 71-76

    7. Interaction of Substrate and Pterin Cofactor with the Metal of Human Tyrosine Hydroxylase as Determined by 1H-NMR

      • Aurora Martínez, Chitrananda Abeygunawardana, Jan Haavik, Torgeir Flatmark, Albert S. Mildvan
      Pages 77-80

    8. Mechanistic Studies of Tyrosine Hydroxylase

      • Paul F. Fitzpatrick
      Pages 81-86

    9. Alleviation of Catecholamine Inhibition of Tyrosine Hydroxylase by Phosphorylation at Serine40

      • S. Colette Daubner, Paul F. Fitzpatrick
      Pages 87-92

    10. Glyceryl Ether Monooxygenase [EC 1.14.16.5]: Stoichiometry and Inhibition

      • Behjat Kosar-Hashemi, Hiroyasu Taguchi, Wilfred L. F. Armarego
      Pages 93-96

  4. Tetrahydrobiopterin Regenerating Enzymes

    1. The Isolation and Characterization of Clones of 4a-Hydroxytetrahydrobiopterin Dehydratase

      • Seymour Kaufman, Bruce A. Citron, Michael Davis, Sheldon Milstien
      Pages 97-102
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Keywords

About this book

The pteridines in their multitude of forms fulfill many roles in nature ranging from pigments to cofactors for numerous redox and one-carbon transfer reactions. This extraordinary diversity of function is unified by the unique chemistry of the pteridine heterocycle. The International Symposium on the Chemistry and Biology of Pteridines and Folates is a forum for presenting recent and exciting advances in this expanding field. In of ideas results that has often stimulated bringing together various disciplines, a synergy fresh approaches to major problems. The Tenth International Symposium held at Orange Beach, Alabama, March 21-23, 1993, proved no exception by providing new insights into folate enzymology, tetrahydrobiopterin and molybdopterin biosynthesis and function, enzyme synthesis and regulation, along with novel synthetic strategies for producing compounds that will expedite further study. The many outstanding scientific contributions found in the following chapters, which represent the work presented at the Symposium, are a reflection of the significant advances made since the Ninth International Symposium held in Zurich in 1989. Since the 7th International Symposium in St. Andrews, Scotland, a tradition has evolved of honoring scientists who have made outstanding contributions to pteridine research with a Gowland Hopkins medal and lectureship. Sir Frederick Gowland Hopkins initiated the first investigation of what later proved to be pteridines in his studies of the yellow and white colors of butterflies.

Editors and Affiliations

  • Dept of Pharmacology College of Medicine, Universily of South Alabama, Mobile, USA

    June E. Ayling

  • Dept. of Biochemistry College of Medicine, University of South Alabama, Mobile, USA

    M. Gopal Nair

  • College of Medicine, Universily of South Alabama, Mobile, USA

    Charles M. Baugh

Bibliographic Information

  • Book Title: Chemistry and Biology of Pteridines and Folates

  • Editors: June E. Ayling, M. Gopal Nair, Charles M. Baugh

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-2960-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1993

  • Hardcover ISBN: 978-0-306-44581-1Published: 31 October 1993

  • Softcover ISBN: 978-1-4613-6287-6Published: 02 May 2013

  • eBook ISBN: 978-1-4615-2960-6Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXVI, 801

  • Topics: Pharmacology/Toxicology, Biochemistry, general, Physical Chemistry, Organic Chemistry

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