Dendritic Cells in Fundamental and Clinical Immunology

1. Front Matter

   Pages i-xvi

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2. Dendritic cells: Antigen Presentation, Accessory Function and Clinical Relevance

   1. Dendritic Cells: Antigen Presentation, Accessory Function and Clinical Relevance

      • Ralph M. Steinman, Margit Witmer-Pack, Kayo Inaba

      Pages 1-9

3. Cellular and Molecular Biology of Antigen Presentation

   1. Endocytic Activity of Dendritic Cells is Similar to Other Antigen Presenting Cells

      • Timothy P. Levine, Benjamin M. Chain

      Pages 11-15

   2. Immunocytochemical Characterization of Dendritic Cells

      • Joanne M. S. Arkema, Inge L. Schadee-Eestermans, Donna M. Broekhuis-Fluitsma, Elisabeth C. M. Hoefsmit

      Pages 17-21

   3. Requirements of Exogenous Protein Antigens for Presentation to CD4+ T lymphocytes By MHC Class II-Positive APC

      • Gernot Gradehandt, Johannes Hampl, Nadja Kleber, Christina Lobron, Silke Milbradt, Burkhard Schmidt et al.

      Pages 23-27

   4. Modulation of MHC Class II Determinants on Rat Langerhans Cells During Short Term Culture

      • Ursula Neiß, Konrad Reske, Detlef Becker, Jürgen Knop

      Pages 29-34

   5. A Dendritic Cell Specific Determinant Present In Endosomes Is Involved in the Presentation of Protein Antigens

      • Toshiyuki Maruyama, Elisabeth C. M. Hoefsmit, Georg Kraal

      Pages 35-39

   6. Dendritic Cells are Potent Antigen-Presenting Cells for Microbial Superantigen

      • Sharifah Iqball, Penelope Bedford, Stella Knight, Reshma Bhatt, Peter Borriello

      Pages 41-46

   7. Divergent T-cell Cytokine Profiles Induced by Dendritic Cells from Different Tissues

      • Michael P. Everson, William J. Koopman, Kenneth W. Beagley

      Pages 47-52

   8. Adhesion Molecules: Co-Stimulators and Co-Mitogens in Dendritic Cell - T Cell Interaction

      • Philip D. King, Mohammad A. A. Ibrahim, David R. Katz

      Pages 53-58

   9. Dendritic Cell Dependent Expression of IgA By Clones in T/B Microcultures

      • Carol E. Schrader, John J. Cebra

      Pages 59-64

   10. Adhesion Molecules in Tonsil DC-T Cell Interactions

       • Derek N. J. Hart, Timothy C. R. Prickett

       Pages 65-69

   11. Dendritic Cells Have Reduced Cell Surface Membrane Glycoproteins Including CD43 Determinants

       • William Egner, Barry D. Hock, Derek N. J. Hart

       Pages 71-73

   12. The Effect of Human Dendritic Cells on the Lectin-Induced Responsiveness of CD4+ T Cells To IL-2 and IL-4

       • Sergiusz Markowicz, Anita Mehta

       Pages 75-80

   13. Analysis of Cytokine and Cytokine Receptor Production by Human Dendritic Cells

       • Victoria L. Calder, Timothy C. R. Prickett, Judith L. McKenzie, Derek N. J. Hart

       Pages 81-85

   14. Costimulating Factors and Signals Relevant for Antigen Presenting Cell Function

       • Marc K. Jenkins, Dimuthu R. DeSilva, Julia G. Johnson, Steven D. Norton

       Pages 87-92

4. Antigen Presenting Cells in T Cell Regulation and Repertoire Selection

   1. Distinct T Cell Stimulation Mechanism and Phenotype of Human Blood Dendritic Cells

      • Hui Xu, Ulrike Friedrichs, Robert K. H. Gieseler, Jörg Ruppert, J. Hinrich Peters, Göran Ocklind

      Pages 93-98

   2. The Role Of Dendritic Cells in the Regulation of T Cell Cytokine Synthesis

      • Joanna Ellis, Mohammed A. A. Ibrahim, Benjamin M. Chain, David R. Katz

      Pages 99-104

   3. The Role of Dendritic Cells as Co-Stimulators in Tolerance Induction

      • Michal Dabrowski, Mohammad A. A. Ibrahim, Benjamin M. Chain, David R. Katz

      Pages 105-110

   4. The Influence of Dendritic Cells on T-Cell Cytokine Production

      • Erna van Wilsem, John Brevé, Georg Kraal, Ingrid van Hoogstraten, Huub Savelkoul

      Pages 111-115

These Proceedings contain the contributions of the participants of the Second International Symposium on Dendritic Cells that was held from the 1st to 25th of June 1992 in Amsterdam, the Netherlands. The First International Symposium on Dendritic Cells was organized as a Satellite symposium at the occasion of the 30th anniversary of the Japanese Reticuloendothelial Society by Dr. Y. Imai in Yamagata (Japan), in 1990. It was entitled "Dendritic Cells in Lymphoid Tissues," and focused primarily on the Interdigitating Cells (IDC), Epidermal Langerhans cells (LC) and Follicular Dendritic Cells (FDC) , from the point of view of human pathology. However, the concept of Dendritic Cell System, comprising the bone marrow derived IDC and LC but not the FDC, was based on animal experiments and mainly on in vitro experiments on isolated cells. In a report from the Reticuloendothelial Society Committee on Nomenclature in 1982, Tew, Thorbecke and Steinman had already characterized these different types of DC, but the gap between in vivo and in vitro function remained. In Amsterdam, the Symposium focused on the Role of Dendritic Cells in Fundamental and Clinical Immunology. First, recent developments in molecular biology of antigen presentation and cell biological aspects of signal transduction were discussed, in relation to the potential of DC to stimulate lymphocytes and to trigger their in vitro differentiation.

• Antigen
• antigen presentation
• biology
• cell
• development
• lymphocytes
• molecular biology
• pathology
• society
• system
• tissue

• Vrije Universiteit, Amsterdam, The Netherlands

  Eduard W. A. Kamperdijk, Elisabeth C. M. Hoefsmit

• University of Groningen, Groningen, The Netherlands

  Paul Nieuwenhuis

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