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Frontiers in Cerebral Vascular Biology

Transport and Its Regulation

  • Book
  • © 1993

Overview

Editors:
  1. Lester R. Drewes

    1. University of Minnesota, Duluth, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. A. Lorris Betz

    1. The University of Michigan, Ann Arbor, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 331)

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Table of contents (44 chapters)

  1. Front Matter

    Pages i-x
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  2. Glucose Transport

    1. Front Matter

      Pages 1-1
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    2. Developmental Expression of Glucose Transporters, Glut1 and Glut3, in Postnatal Rat Brain

      • Susan J. Vannucci, Lisa B. Willing, Robert C. Vannucci
      Pages 3-7

    3. Alterations in Brain Glucose Transporter Proteins, Glut1 and Glut3, in Streptozotocin Diabetic Rats

      • Fran Maher, Ian A. Simpson, Susan J. Vannucci
      Pages 9-12

    4. Glucose Transporter (Glut1) Expression by Canine Brain Microvessel Endothelial Cells in Culture: An Immunocytochemical Study

      • Jay M. Hemmila, Lester R. Drewes
      Pages 13-18

    5. Application of Novel PCR Strategies to Amplify and Sequence Glucose Transporters in Canine Brain

      • Nancy D. Borson, Wilmar L. Salo, Lester R. Drewes
      Pages 19-24

    6. Estimation of Unidirectional Clearances of FDG and Glucose Across the Blood-Brain Barrier in Man

      • Steen Hasselbalch, Gitte Moos Knudsen, Johannes Jakobsen, Søren Holm, Olaf B. Paulson
      Pages 25-27

    7. Rat Brain Glucose Concentration and Transport Kinetics Determined with 13C Nuclear Magnetic Resonance Spectroscopy

      • Graeme F. Mason, Kevin L. Behar, Margaret A. Martin, Robert G. Shulman
      Pages 29-34

    8. Non-Invasive Measurements of the Cerebral Steady-State Glucose Concentration and Transport in Humans by 13C Nuclear Magnetic Resonance

      • Rolf Gruetter, Edward J. Novotny, Susan D. Boulware, Douglas L. Rothman, Graeme F. Mason, Gerald I. Shulman et al.
      Pages 35-40

  3. Electrolyte Transport

    1. Front Matter

      Pages 41-41
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    2. Potassium Transport at the Blood-Brain and Blood-CSF Barriers

      • Richard F. Keep, Jianming Xiang, A. Lorris Betz
      Pages 43-54

    3. Expression of Na, K-ATPase at the Blood-Brain Interface

      • Berislav V. Zlokovic, Liang Wang, Jasmina B. Mackic, Asma J. Saraj, J. Gordon McComb, Alicia McDonough
      Pages 55-60

    4. Effects of Protein Kinase C Agonists on Na, K-ATPase Activity in Rat Brain Microvessels

      • Hiroo Johshita, Takao Asano, Tohru Matsui, Tohru Koide
      Pages 61-64

    5. Brain Volume Regulation During Development: The Role of Blood-Brain Barrier Potassium Transport

      • Richard F. Keep, Jianming Xiang, Steven R. Ennis, Mary E. Beer, A. Lorris Betz
      Pages 65-69

    6. The Transendothelial DC Potential of Rat Blood-Brain Barrier Vessels in Situ

      • Patricia A. Revest, Hazel C. Jones, N. Joan Abbott
      Pages 71-74

    7. Phosphate Transport in Capillaries of the Blood-Brain Barrier

      • Richard Béliveau, Lise Dallaire, Sylvie Giroux
      Pages 75-80

  4. Drug and Amino Acid Transport

    1. Front Matter

      Pages 81-81
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    2. Drug Delivery to Brain and the Role of Carrier-Mediated Transport

      • Quentin R. Smith
      Pages 83-93

    3. Vasopressin Modulates the Blood-Brain Transfer of Amino Acids-Studies with [11C]Methionine in Dogs

      • Peter Brust, Dean F. Wong, Albert Gjedde, Armin Ermisch
      Pages 95-100

    4. Amino Acid Transport at the Blood-Nerve Barrier of the Rat Peripheral Nerve

      • Kishena C. Wadhwani, Quentin R. Smith, Stanley I. Rapoport
      Pages 101-106
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Keywords

About this book

During the past three decades, the cerebral vasculature and its role in blood-brain transport has been an increasingly active area of investigation and learning, particularly from an anatomical and physiological point of view. However, much less is known at the molecular and cellular level about the blood-brain barrier especially regarding the macromolecules responsible for transport, the roles played by vascular wall components (endothelial cell, pericyte, smooth muscle, basement membrane), and the mechanisms regulating brain vascular-specific protein expression and their molecular alterations during development and disease. Fundamental questions still unanswered include: What are the molecular constituents of brain endothelial cell tight junctions? What are the membrane proteins responsible for transport of specific substrates? What are the molecular signals that cause glucose transporter gene expression to be 20 to 100 times greater in brain endothelial cells in vivo than in vitro? What roles do pericytes, smooth muscle cells and basement membrane have in establishing or maintaining blood-brain transport characteristics? Are brain vascular transport systems responsible for edema following injury? Are transporter systems regulated via receptor-mediated events? Do hormones or neuromodulators regulate transporter expression? What is the molecular mechanism by which plasma proteins enter the extravascular space? Are transporters asymmetrically distributed between the luminal and abluminal endothelial cell membranes? Can prodrugs or pharmacologic agents be designed as substrate analogs and be delivered to the central nervous system via existing transporters or receptors? Can new and beneficial transporters be introduced into the brain vasculature?

Editors and Affiliations

  • University of Minnesota, Duluth, USA

    Lester R. Drewes

  • The University of Michigan, Ann Arbor, USA

    A. Lorris Betz

Bibliographic Information

  • Book Title: Frontiers in Cerebral Vascular Biology

  • Book Subtitle: Transport and Its Regulation

  • Editors: Lester R. Drewes, A. Lorris Betz

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-2920-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1993

  • Hardcover ISBN: 978-0-306-44416-6Due: 31 May 1993

  • Softcover ISBN: 978-1-4613-6267-8Published: 26 July 2012

  • eBook ISBN: 978-1-4615-2920-0Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 306

  • Number of Illustrations: 76 b/w illustrations

  • Topics: Neurology, Neurosurgery, Pharmacology/Toxicology, Animal Anatomy / Morphology / Histology, Plant Sciences, Neurosciences

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