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New Concepts in the Pathogenesis of NIDDM

  • Book
  • © 1993

Overview

Editors:
  1. Claes Göran Östenson

    1. Karolinska Hospital, Stockholm, Sweden

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  2. Suad Efendić

    1. Karolinska Hospital, Stockholm, Sweden

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  3. Mladen Vranic

    1. University of Toronto, Toronto, Canada

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 334)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Regulation of Insulin Secretion

    1. Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM

      • Claes-Göran Östenson, Akhtar Khan, Suad Efendic
      Pages 1-11

    2. Perturbation of Islet Metabolism and Insulin Release in NIDDM

      • Willy J. Malaisse
      Pages 13-23

    3. Regulation of Cytoplasmic Free Ca2+ in Insulin-Secreting Cells

      • Per-Olof Berggren, Per Arkhammar, Md Shahidul Islam, Lisa Juntti-Berggren, Akhtar Khan, Henrik Kindmark et al.
      Pages 25-45

    4. The ß-Cell Sulfonylurea Receptor

      • Stephen J. H. Ashcroft, Ichiro Niki, Sue Kenna, Ling Weng, Jackie Skeer, Barbara Coles et al.
      Pages 47-61

  3. Insulin,Insulin Receptors and Glucose Transporters

    1. Regulation of Glucose Transporters and the Na/K-ATPase by Insulin in Skeletal Muscle

      • Harinder S. Hundal, Amira Klip
      Pages 63-78

    2. Insulin Receptor: Aspects of its Structure and Function

      • Cecil C. Yip
      Pages 79-88

    3. The Diabetogenes Concept of NIDDM

      • Pierre De Meyts
      Pages 89-100

    4. Molecular Genetics of NIDDM and the Genes for Insulin and Insulin Receptor

      • Holger Luthman, Ingrid Delin, Anna Glaser, Rolf Luft, Svante Norgren, Anna Wedell
      Pages 101-111

    5. Autoregulation of Glucose Transport: Effects of Glucose on Glucose Transporter Expression and Cellular Location in Muscle

      • Shlomo Sasson, Yaqoub Ashhab, Danielle Melloul, Erol Cerasi
      Pages 113-127

  4. Insulin Action in NIDDM

    1. Insulin Resistance and the Pathogenesis of Non-Insulin Dependent Diabetes Mellitus: Cellular and Molecular Mechanisms

      • Jerrold M. Olefsky
      Pages 129-150

    2. Indirect Effects of Insulin in Regulating Glucose Fluxes

      • Z. Q. Shi, A. Giacca, S. J. Fisher, M. Lekas, D. Bilinski, M. Van Delangeryt et al.
      Pages 151-168

    3. The Insulin-Antagonistic Effect of the Counterregulatory Hormones — Clinical and Mechanistic Aspects

      • Ulf Smith, Stig Attvall, Jan Eriksson, Jesper Fowelin, Peter Lönnroth, Christian Wesslau
      Pages 169-180

    4. On Insulin Action in Vivo: The Single Gateway Hypothesis

      • Richard N. Bergman, David C. Bradley, Marilyn Ader
      Pages 181-198

  5. Gluconeogenesis

    1. Acute Hormonal Regulation of Gluconeogenesis in the Conscious Dog

      • Alan D. Cherrington, Ralph W. Stevenson, Kurt E. Steiner, Cynthia C. Connolly, Masahiko Wada, Richard E. Goldstein
      Pages 199-208

    2. Estimating Gluconeogenic Rates in NIDDM

      • Bernard R. Landau
      Pages 209-220

    3. Glucose Metabolism During Physical Exercise in Patients with Noninsulin-Dependent (Type II) Diabetes

      • Iva K. Martin, John Wahren
      Pages 221-233

    4. Substrates and the Regulation of Hepatic Glycogen Metabolism

      • Jerry Radziuk, Susan Pye, Zi Zhang
      Pages 235-252

    5. Gluconeogenesis in Type 2 Diabetes

      • John E. Gerich, Nurjahan Nurjhan
      Pages 253-258
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Keywords

About this book

The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia­ betes research, hoping that this type of interaction may result in new concepts and treat­ ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ.Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Editors and Affiliations

  • Karolinska Hospital, Stockholm, Sweden

    Claes Göran Östenson, Suad Efendić

  • University of Toronto, Toronto, Canada

    Mladen Vranic

Bibliographic Information

  • Book Title: New Concepts in the Pathogenesis of NIDDM

  • Editors: Claes Göran Östenson, Suad Efendić, Mladen Vranic

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-2910-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1993

  • Hardcover ISBN: 978-0-306-44563-7Published: 30 September 1993

  • Softcover ISBN: 978-1-4613-6262-3Published: 24 October 2012

  • eBook ISBN: 978-1-4615-2910-1Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: IX, 316

  • Topics: Diabetes, Internal Medicine, Biochemistry, general, Animal Anatomy / Morphology / Histology, Plant Sciences

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