Mechanism of Myofilament Sliding in Muscle Contraction

1. Front Matter

   Pages i-xvi

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2. Introductory Lecture on Muscle Contraction

   1. Introductory Lecture on Muscle Contraction

      • A. F. Huxley

      Pages 1-9

3. Structural Basis of Myofilament Sliding

   1. Front Matter

      Pages 11-11

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   2. A Comparison of the Atomic Model of F-Actin with Cryo-Electron Micrographs of Actin and Decorated Actin

      • K. C. Holmes, M. Tirion, D. Popp, M. Lorenz, W. Kabsch, R. A. Milligan

      Pages 15-24

   3. A New Crystal Form of Tropomyosin

      • Andrea Miegel, Lan Lee, Zbigniew Dauter, Yuichiro Maéda

      Pages 25-32

   4. Experiments on Rigor Crossbridge Action and Filament Sliding in Insect Flight Muscle

      • M. K. Reedy, C. Lucaveche, M. C. Reedy, B. Somasundaram

      Pages 33-46

   5. Gross Structural Features of Myosin Head During Sliding Movement of Actin as Studied by Quick-Freeze Deep-Etch Electron Microscopy

      • Eisaku Katayama

      Pages 47-55

   6. Cross-Bridge Angle Distribution and Thin Filament Stiffness in Frog Skeletal Muscle Fibers as Studied by Quick-Freeze Deep-Etch Electron Microscopy

      • Suechika Suzuki, Yoko Oshimi, Haruo Sugi

      Pages 57-70

   7. Elastic Properties of Connecting Filaments Along the Sarcomere

      • Károly Trombitás, Gerald H. Pollack

      Pages 71-79

   8. Structural Studies on the Conformations of Myosin

      • A. R. Faruqi, R. A. Cross, J. Kendrick-Jones

      Pages 81-91

4. Regulatory Mechanisms of Contraction

   1. Front Matter

      Pages 93-93

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   2. Activation and Relaxation Mechanisms in Single Muscle Fibres

      • C. C. Ashley, T. J. Lea, I. P. Mulligan, R. E. Palmer, S. J. Simnett

      Pages 97-115

   3. The Molecular Switch in Troponin C

      • John Gergely, Zenon Grabarek, Terence Tao

      Pages 117-123

   4. The Mechanism of Ca2+-Coordination in the EF-Hand of TnC, by Cassette Mutagenesis

      • Árvind Babu, Hong Su, Jagdish Gulati

      Pages 125-131

   5. The Strength of Binding of the Weakly-Binding Crossbridge Created by Sulfhydryl Modification has very Low Calcium Sensitivity

      • Vincent A. Barnett, Mark Schoenberg

      Pages 133-140

   6. Role of Parvalbumin in Relaxation of Frog Skeletal Muscle

      • Tien-tzu Hou, J. David Johnson, Jack A. Rail

      Pages 141-153

   7. Evidence for the Existence of Endothelial Factors Regulating Contractility in Rat Heart

      • Saul Winegrad

      Pages 155-163

   8. Effects of Tropomyosin Deficiency in Flight Muscle of Drosophila Melanogaster

      • Justin Molloy, Andrew Kreuz, Rehae Miller, Terese Tansey, David Maughan

      Pages 165-172

   9. Effect of Myosin Heavy Chain Peptides on Contractile Activation of Skinned Cardiac Muscle Fibres

      • J. C. Rüegg, J. D. Strauss, C. Zeugner, I. Trayer

      Pages 173-181

   10. Cross-Bridges Affect Both TnC Structure and Calcium Affinity in Muscle Fibers

       • A. M. Gordon, E. B. Ridgway

       Pages 183-194

This volume presents the entire proceedings of the symposium organized by one of us (H. S. ) on November 11 to 15, 1991 at Hakone, Japan, under the title of "Mechanism of Myofllament Sliding in Muscle Contraction. " Among various kinds of energy transduction mechanisms in biological systems, the mechanism of muscle contraction has been studied most intensively and extensively over many years. Since the monumental discovery by the two Huxleys and coworkers that muscle contraction results from relative sliding between the thick and thin myofilaments, attention of muscle investigators has been focused on the question, what makes the fllaments slide past one another. In response to the above question, A. F. Huxley and Simmons put forward a contraction model in 1971, in which globular heads of myosin (cross-bridges) extending from the thick fllament first attach to actin on the thin fllament, and then change their angle of attachment to actin (power stroke) leading to force generation or myofilament sliding until they detach from the thin fllament. The rocking cross-bridge contraction model seemed to be entirely consistent with the kinetic scheme of actomyosin ATPase published by Lymn and Taylor at the same time, thus giving a strong impression to the people concerned that the muscle contraction mechanism would soon be sorted out. In his review lecture in 1974, however, A. F.

• ATP
• ATPase
• X-ray
• smooth muscle
• temperature

• Teikyo University, Tokyo, Japan

  Haruo Sugi

• University of Washington, Seattle, USA

  Gerald H. Pollack

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