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Dimorphic Fungi in Biology and Medicine

  • Book
  • © 1993

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Editors:
  1. Hugo Bossche

    1. Janssen Research Foundation, Beerse, Belgium

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  2. Frank C. Odds

    1. Janssen Research Foundation, Beerse, Belgium

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  3. David Kerridge

    1. University of Cambridge, Cambridge, UK

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Table of contents (37 chapters)

  1. Front Matter

    Pages i-x
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  2. Introductory Paper

    1. Front Matter

      Pages 1-1
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    2. Fungal Dimorphism: A Sideways Look

      • David Kerridge
      Pages 3-10

  3. Molecular Genetics of Morphogenetic Processes

    1. Front Matter

      Pages 11-11
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    2. Molecular Controls of Conidiogenesis in Aspergillus Nidulans

      • William E. Timberlake
      Pages 13-22

    3. Physical and Genetic Mapping of Candida Albicans

      • B. B. Magee, Wen-Shen Chu, Bernhard Hube, Rachel J. Wright, E. H. A. Rikkerink, P. A. Sullivan
      Pages 23-35

    4. Genetic Basis for Dimorphism and Pathogenicity in Candida Albicans

      • William A. Fonzi, Susan Saporito-Irwin, Jiang-Ye Chen, Paul Sypherd
      Pages 37-50

    5. The Multiple Chitin Synthase Genes of Candida Albicans and Other Pathogenic Fungi — A Review

      • P. W. Robbins, A. R. Bowen, J. L. Chen-Wu, M. Momany, P. J. Szaniszlo, J. Zwicker
      Pages 51-59

    6. Key Genes in the Regulation of Dimorphism of Candida Albicans

      • Neil A. R. Gow, Rolf Swoboda, Gwyneth Bertram, Graham W. Gooday, Alistair J. P. Brown
      Pages 61-71

    7. Switching and the Regulation of Gene Transcription in Candida Albicans

      • David R. Soll
      Pages 73-82

    8. Characterization of Saccharomyces Cerevisiae Pseudohyphal Growth

      • Carlos J. Gimeno, Per O. Ljungdahl, Cora A. Styles, Gerald R. Fink
      Pages 83-103

    9. Phase Transition in Wangiella Dermatitidis: Identification of Cell-Division-Cycle Genes Involved in Yeast Bud Emergence

      • Chester R. Cooper Jr.
      Pages 105-119

  4. Cell Biology and Biochemistry

    1. Front Matter

      Pages 121-121
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    2. Morphological Aspects of Fungal Dimorphism

      • Marcel Borgers
      Pages 123-131

    3. Mathematical Analysis of the Cellular Basis of Fungal Dimorphism

      • Salomon Bartnicki-Garcia, Gerhard Gierz
      Pages 133-144

    4. Quantification of Candida Morphology in Vitro and in Vivo

      • Frank C. Odds
      Pages 145-151

    5. Nature and Control of Cell Wall Biosynthesis

      • Maxwell G. Shepherd, Pramod K. Gopal
      Pages 153-167

    6. Possible Roles of Mannoproteins in the Construction of Candida Albicans Cell Wall

      • Rafael Sentandreu, Maria Victoria Elorza, Salvador Mormeneo, Raquel Sanjuan, Maria Iranzo
      Pages 169-175

    7. Is there a Role for Sterols and Steroids in Fungal Growth and Transition from Yeast to Hyphal-Form and Vice Versa? An Overview

      • Hugo Vanden Bossche, Patrick Marichal
      Pages 177-190

    8. Factors Regulating Morphogenesis in Coccidioides Immitis

      • Garry T. Cole, David Kruse, Kalpathi R. Seshan, Shuchong Pan, Paul J. Szaniszlo, Jon Richardson et al.
      Pages 191-212
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Keywords

About this book

Fungal dimorphism is a topic that sounds inherently too rarified to attract more than a specialist audience. Yet some 230 individuals representing an eclectic mixture of interests, from basic science to medical practice, gathered in Churchill College, Cambridge in Semptember 1992 for a meeting devoted only to this subject. The symposium was the fourth in a series "Topics in Mycology" to be jointly organized by the Janssen Research Foundation and the International Society for Human and Animal Mycology. The participants enjoyed a rich and varied diet of oral presentations and poster displays in the field of fungal morphogenesis. This book sets down in print the material presented at the dimorphism symposium. We think that the high quality of these papers conveys very well the flavor of what was an excellent meeting. The selection of contributions in this volume covers very wide ground indeed. Chapters devoted to some non-pathogenic fungi are included, because the scientific basis of morphological development belongs to the fields of cellular and molecular biology: it does not recognize the boundary imposed by considerations of virulence of a fungus for a human host. Yet morphogenetic change in those fungi that do cause human disease frequently appears to be a component of the pathological process: many important pathogens change from a hyphal form in the external environment to a round form in infected tissues. This relationship between dimorphism and pathogenicity is the point of contact between pure biology and medicine.

Editors and Affiliations

  • Janssen Research Foundation, Beerse, Belgium

    Hugo Bossche, Frank C. Odds

  • University of Cambridge, Cambridge, UK

    David Kerridge

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