Mammary Tumorigenesis and Malignant Progression

1. Front Matter

   Pages i-xiv

   PDF

2. Proliferation, Differentiation, and Malignant Progression

   1. Front Matter

      Pages 1-1

      PDF

   2. Morphological and biological observations relating to the development and progression of breast cancer

      • Thomas J. Anderson, William R. Miller

      Pages 3-27

   3. Growth, differentiation, and transformation of human mammary epithelial cells in culture

      • Martha R. Stampfer, Paul Yaswen

      Pages 29-48

3. Genetic Basis for Cancer Onset and Progression

   1. Front Matter

      Pages 49-49

      PDF

   2. Genetic analysis of breast and ovarian cancer in families

      • Mary-Claire King, Sarah Rowell

      Pages 51-62

   3. The p53 tumor-suppressor gene in human breast cancer

      • D. Craig Allred, Richard Elledge, Gary M. Clark, Suzanne A. W. Fuqua

      Pages 63-77

   4. Tumor-suppressor genes in breast cancer progression

      • Helene S. Smith

      Pages 79-96

   5. Estrogen receptor variants in breast cancer

      • Carlos A. Encarnacion, Suzanne A. W. Fuqua

      Pages 97-109

   6. Hormone ‘resistance’ in breast cancer: The role of normal and mutant steroid receptors

      • Kathryn B. Horwitz

      Pages 111-127

4. Growth Factors, Receptors, and Polyamines

   1. Front Matter

      Pages 129-129

      PDF

   2. The epidermal growth factor family in the mammary gland and other target organs for ovarian steroids

      • Richard P. DiAugustine

      Pages 131-160

   3. Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase

      • Ilana Stancovski, Michael Sela, Yosef Yarden

      Pages 161-191

   4. MDGF1: A multifunctional growth factor in human milk and human breast cancer

      • Mozeena Bano, William R. Kidwell, Robert B. Dickson

      Pages 193-208

   5. The role of polyamines in the hormonal control of breast cancer cell proliferation

      • Andrea Manni

      Pages 209-225

5. Cancer Cell Adhesion, Migration, and Proteolysis

   1. Front Matter

      Pages 227-227

      PDF

   2. Modulations of the epithelial phenotype during embryogenesis and cancer progression

      • Pierre Savagner, Brigitte Boyer, Ana Maria Valles, Jacqueline Jouanneau, Jean Paul Thiery

      Pages 229-249

   3. Cell-cell adhesion in invasion and metastasis of carcinomas

      • Jürgen Behrens, Walter Birchmeier

      Pages 251-266

   4. Enhancement of tumor growth by basement membrane: Modulation of growth and angiogenesis by laminin-derived synthetic peptides

      • Maura C. Kibbey, Keizo Yamamura, Soo Han Jun, Derrick S. Grant, Hynda K. Kleinman

      Pages 267-275

   5. Fetal-like fibroblasts: Their production of migration-stimulating factor and role in tumor progression

      • Seth L. Schor, Anne Marie Grey, Ian Ellis, Ana M. Schor, Anthony Howell, Philip Sloan et al.

      Pages 277-298

The current volume represents the fourth over a period of five years in our series on Advances in the Cellular and Molecular Biology of Breast Cancer. The first three volumes were entitled Breast Cancer: Cellular and Molecular Biology, Regulatory Mechanisms in Breast Cancer, and Genes, Oncogenes, and Hormones, respectively. Throughout this series, we have tried to take a broad look at cutting-edge topics in basic science research into breast cancer. This attempt has resulted in a wide range of subject material, including rodent and human model systems, oncogenes, suppressor genes, growth factors, hormones, tumor-host interactions, and determinants of metastases. Since our last volume, research in breast cancer has continued to proceed at an explosive rate. We hope the current volume will provide the reader with some of the excitement felt by the editors and authors as we begin to understand this all-too-common disease. The first section of this book is devoted to the basic processes of proli­ feration, differentiation, and malignant progression of breast cancer. T.l. Anderson and W.R. Miller lead off with a detailed description of controls on proliferation in the normal human breast and in breast cancer. This chapter strongly emphasizes pathological aspects. The second chapter, by M.R. Stampfer and P. Yaswen, presents a corresponding viewpoint through a presentation of experiments with human mammary epithelial cells in culture. The second section of the book emphasizes the genetic basis for breast cancer onset and malignant progression. Chapter 3, by M.-C. King and S.

• angiogenesis
• biology
• carcinogenesis
• carcinoma
• genes
• hormones
• metastasis
• molecular biology
• oncogene
• ovarian cancer
• proliferation
• steroids
• tumor
• tumor growth
• tumorigenesis

• Lombardi Cancer Research Center, Georgetown University School of Medicine, USA

  Robert B. Dickson, Marc E. Lippman

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