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Novel Approaches to Selective Treatments of Human Solid Tumors

Laboratory and Clinical Correlation

  • Book
  • © 1993

Overview

Editors:
  1. Youcef M. Rustum

    1. Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, USA

    View editor publications

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 339)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Fluoropyrimidine Metabolism and Mechanism of Action

    1. 5-Fluoro-2′-Deoxyuridine: Role of Schedule in its Therapeutic Efficacy

      • Shousong Cao, Zhanggeng Zhang, Patrick J. Creaven, Youcef M. Rustum
      Pages 1-8

    2. Comparison of Continuous Infusions and Bolus Injections of 5.Fluorouracil with or without Leucovorin: Implications for Inhibition of Thymidylate Synthase

      • Godefridus J. Peters, Giovanni Codacci-Pisanelli, Clasina L. van der Wilt, Jan A. M. van Laar, Kees Smid, Paul Noordhuis et al.
      Pages 9-21

  3. Critical Questions for the Future Direction of FU/LV

    1. Cellular Interactions Between the Natural and Unnatural Isomers of 5-Formyltetrahydrofolate

      • Jacques Jolivet, Richard Bertrand
      Pages 23-30

    2. Leucovorin as a Prodrug

      • D. G. Priest, J. C. Schmitz, T. Walle
      Pages 31-42

    3. Clinical Use of Leucovorin: Intracellular Metabolism

      • Carmen J. Allegra, Donna Voeller
      Pages 43-49

    4. Some Considerations Concerning the Dose and Schedule of 5FU and Leucovorin: Toxicities of two Dose Schedules from the Intergroup Colon Adjuvant Trial (INT-0089)

      • Daniel G. Haller, Myrto Lefkopoulou, John S. Macdonald, Robert S. Mayer
      Pages 51-56

    5. Effects of 5-Fluorouracil on mRNA

      • Bruce J. Dolnick, Xi-Pu Wu
      Pages 57-65

    6. Genetic Variation in Thymidylate Synthase Confers Resistance to 5-Fluorodeoxyuridine

      • C. Todd Hughey, Karen W. Barbour, Franklin G. Berger, Sondra H. Berger
      Pages 67-76

    7. Experience with 5FU + L-Leucovorin

      • C. Erlichman, S. Fine, I. Kerr, W. Hoffman, C. Gorg, H.-J. Schmoll et al.
      Pages 77-79

    8. 5-Fluorouracil Combined with the Pure [6S]-Stereoisomer of Folinic Acid in High Doses for Treatment of Patients with Advanced Colorectal Carcinoma: A Phase I–II Study of two Consecutive Regimens

      • David Machover, Xavier Grison, Emma Goldschmidt, Jacqueline Zittoun, Jean-Pierre Lotz, Gerard Metzger et al.
      Pages 81-98

    9. 5-Fluorouracil Modulation in Colorectal Carcinoma Experience of German Investigators

      • Claus-Henning Kohne-Wompner, Hans-Joachim Schmoll
      Pages 99-107

    10. An Overview of Adjuvant Treatment of Colon Cancer

      • Sheldon Fine
      Pages 109-118

    11. Dose-Dependent Inhibition of Aspartate Carbamoyltransferase in Peripheral Blood Mononuclear Cells in Patients Receiving N-(Phosphonacetyl)-L-Aspartate

      • Jean L. Grem, Nanette McAtee, James C. Drake, Seth Steinberg, Carmen J. Allegra
      Pages 119-123

  4. Alternative Approaches to Modulation of Fluoropyrimidines

    1. Increasing the Efficacy of 5-Fluorouracil with Interferons: Preclinical, Clinical, and Pharmacokinetic Studies

      • Joseph A. Sparano, Scott Wadler
      Pages 125-131

    2. Enhanced Cytotoxicity of 5-Fluorouracil Combined with [6RS]Leucovorin and Recombinant Human Interferon-α2a in Colon Carcinoma Cells

      • Janet A. Houghton, David A. Adkins, Peter J. Houghton
      Pages 133-142

    3. Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and Interferon-Gamma

      • Edward Chu, Carmen J. Allegra
      Pages 143-151

    4. Biochemical Modulation of 5-Fluorouracil by Pala: Mechanism of Action

      • Daniel S. Martin
      Pages 153-167

    5. Implications of Chronobiology for 5-Fluorouracil (5-Fu) Efficacy

      • F. Lévi, S. Brienza, G. Metzer, P. Deprés-Brummer, F. Bertheault-Cvitkovic, R. Zidani et al.
      Pages 169-186

  5. Update on Metabolic Modulation as a Therapeutic Approach for Adult Carcinomas

    1. Fluorouracil and Leucovorin in Advanced Breast Cancer

      • James H. Doroshow, Kim Margolin, Lucille Leong, Steven Akman, Robert Morgan Jr., James Raschko et al.
      Pages 187-195
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Keywords

Editors and Affiliations

  • Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, USA

    Youcef M. Rustum

Bibliographic Information

  • Book Title: Novel Approaches to Selective Treatments of Human Solid Tumors

  • Book Subtitle: Laboratory and Clinical Correlation

  • Editors: Youcef M. Rustum

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-2488-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1993

  • Hardcover ISBN: 978-0-306-44592-7Published: 31 January 1994

  • Softcover ISBN: 978-1-4613-6060-5Published: 24 October 2012

  • eBook ISBN: 978-1-4615-2488-5Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XII, 319

  • Topics: Oncology, Pharmacology/Toxicology, Human Genetics, Animal Anatomy / Morphology / Histology, Plant Sciences

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