Mechanisms of Heart Failure

1. Front Matter

   Pages i-xxv

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2. Subcellular Basis of Heart Failure

   1. Front Matter

      Pages 1-1

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   2. Tumor Necrosis Factor-Alpha in Chronic Heart Failure

      • Tiziana Bachetti, Angelo Corti, Amerigo Giordano, Roberto Ferrari

      Pages 3-8

   3. Myocardial Ribonuclease Activity in Heart Failure

      • P. J. O’Brien, H. Shen, J. K. Gwathmey

      Pages 9-18

   4. β-Adrenergic Receptor Mechanisms in Heart Failure

      • Rajat Sethi, Nobuakira Takeda, Makoto Nagano, Naranjan S. Dhalla

      Pages 19-35

   5. Vascular α-Adrenergic Function in Congestive Heart Failure

      • Qing-Ping Feng, J. Malcolm O. Arnold

      Pages 37-50

   6. Altered Myocardial Neurotransmitter and 1,2-Diacylglycerol Concentrations in Right Ventricular Hypertrophy and Failure in Rats

      • Kenji Okumura, Yumiko Yamada, Hideo Matsui, Masanori Shinoda, Kenshin Naruse, Yukio Toki et al.

      Pages 51-62

   7. Metabolic Changes in Nonischemic Myocardium During Pump Failure

      • Haruhiko Ishioka, Eiichi Geshi, Takuya Watanabe, Toshiki Iwata, Seiji Itoh, Shuji Mukae et al.

      Pages 63-74

   8. Cardiac Extracellular Matrix and its Role in the Development of Heart Failure

      • Haisong Ju, Ian M. C. Dixon

      Pages 75-90

   9. SHHF/Mcc-/fa ^cp Rat Model: A Genetic Model of Congestive Heart Failure

      • Sylvia A. McCune, Sonhee Park, M. Judith Radin, Richard R. Jurin

      Pages 91-106

   10. Left Ventricular Mass and Diastolic Function in Young Individuals With a First Elevated “Casual” Blood Pressure

       • Susana M. De Lena, Eduardo Escudero, Daniel Olano, Horacio E. Cingolani

       Pages 107-115

   11. Factors Responsible for Left Ventricular Underfilling in Pure Mitral Stenosis

       • Andrzej Surdacki, Jacek Legutko, Paweł Turek, Dariusz Dudek, Krzysztof Żmudka, Jacek S. Dubiel

       Pages 117-127

   12. Improved Preservation of Myocardial Ultrastructure in Perfusion-Fixed Human Heart Explants

       • A. Martin Gerdes, Jan H. Prokosch-Graves, Harry E. Settles, James A. Burbach, Douglas D. Schocken

       Pages 129-141

   13. Involvement of Leukotoxin in the Pathogenesis of Patients with Extensive Burns

       • Kazuhiro Kosaka, Kohji Suzuki, Mika Hayakawa, Satoru Sugiyama, Takayuki Ozawa

       Pages 143-151

   14. Differential Regulation of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase Isozymes

       • Rajendra K. Sharma, Jawahar Kalra, Yingchun Tan

       Pages 153-166

3. Pathophysiologic Aspects of Cardiomyopathies

   1. Front Matter

      Pages 167-167

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   2. Adriamycin Cardiomyopathy and Its Prevention in an Animal Model

      • Natasha Siveski-Iliskovic, Timao Li, Pawan K. Singal

      Pages 169-176

   3. Alterations in Sarcolemmal Phospholipid Base Exchange Enzymatic Activities in Diabetic Cardiomyopathy

      • Alba Vecchini, Luciano Binaglia, Paolo Di Nardo, Marilena Minieri, Jaen-Anne E. Hays, Vincenzo Panagia et al.

      Pages 177-184

   4. Myocardial Lipid Peroxidation and Diabetes

      • Sushil K. Jain

      Pages 185-195

   5. Molecular biologic Changes of Adenine Nucleotide Translocator in J-2-N Cardiomyopathic Hamsters

      • Mitsutoshi Kato, Shohei Yamashina, Masahito Tsuchiya, Nobuakira Takeda, Seibu Mochizuki, Takeshi Morishita et al.

      Pages 197-202

Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

• Angiotensin II
• Laboratory
• blood pressure
• heart
• heart disease
• heart failure
• hemodynamics
• muscle
• myocardial infarction
• necrosis
• nervous system
• organ
• signal transduction
• transplantation
• treatment

• MRC Group in Experimental Cardiology Division of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

  Pawan K. Singal, Ian M. C. Dixon, Robert E. Beamish, Naranjan S. Dhalla

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