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Cell Activation and Apoptosis in HIV Infection

Implications for Pathogenesis and Therapy

  • Book
  • © 1995

Overview

Editors:
  1. Jean-Marie Andrieu

    1. Laennec Hospital, Paris, France

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    You can also search for this editor in PubMed   Google Scholar

  2. Wei Lu

    1. Laennec Hospital, Paris, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 374)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xi
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  2. CD4+ and CD8+ T Lymphocyte Activation in HIV Infection

    • Jeffrey Laurence
    Pages 1-15

  3. Markers of Immune Cell Activation and Disease Progression

    • M. Peakman, M. Mahalingam, A. Pozniak, T. J. McManus, A. N. Phillips, D. Vergani
    Pages 17-26

  4. The Role of the Cell Cycle in HIV-1 Infection

    • Jerome A. Zack
    Pages 27-31

  5. Molecular Basis of Cell Cycle Dependent HIV-1 Replication

    • M. Stevenson, B. Brichacek, N. Heinzinger, S. Swindells, S. Pirruccello, E. Janoff et al.
    Pages 33-45

  6. Regulation of Macrophage Activation and HIV Replication

    • Luis J. Montaner, Georges Herbein, Siamon Gordon
    Pages 47-56

  7. Investigations on Autologous T-Cells for Adoptive Immunotherapy of Aids

    • Jan van Lunzen, Jörn Schmitz, Kathrin Dengler, Claudia Kuhlmann, Herbert Schmitz, Manfred Dietrich
    Pages 57-70

  8. Rational Problems Associated with the Development of Cellular Approaches in Controlling HIV Spread

    • Aldar S. Bourinbaiar, Sylvia Lee-Huang
    Pages 71-89

  9. The Role of Surface CD4 in HIV-Induced Apoptosis

    • Jacques Corbeil, Douglas D. Richman
    Pages 91-99

  10. Mechanism of Apoptosis in Peripheral Blood Mononuclear Cells Of HIV-Infected Patients

    • Naoki Oyaizu, Thomas W. Mc Closkey, Soe Than, Rong Hu, Savita Pahwa
    Pages 101-114

  11. Programmed Death of T Cells in the Course of HIV Infection

    • Linde Meyaard, Frank Miedema
    Pages 115-120

  12. T Cell Apoptosis as a Consequence of Chronic Activation of the Immune System in HIV Infection

    • Marie-Lise Gougeon
    Pages 121-127

  13. Apoptosis During HIV Infection

    • Seamus J. Martin, Douglas R. Green
    Pages 129-138

  14. From Cell Activation to Cell Depletion

    • Jean Claude Ameisen
    Pages 139-163

  15. Immunosuppression by a Noncytolytic Virus Via T Cell Mediated Immunopathology

    • Rolf M. Zinkernagel
    Pages 165-171

  16. Clonal Expansion of T Cells and HIV Genotypes in Microdissected Splenic White Pulps Indicates Viral Replication in Situ and Infiltration of HIV-Specific Cytotoxic T Lymphocytes

    • Rémi Cheynier, Sven Henrichwark, Fabienne Hadida, Eric Pelletier, Eric Oksenhendler, Brigitte Autran et al.
    Pages 173-182

  17. Autoimmunity, Apoptosis Defects and Retroviruses

    • J. D. Mountz, J. Cheng, X. Su, J. Wu, T. Zhou
    Pages 183-201

  18. Aids as Immune System Activation

    • Michael S. Ascher, Haynes W. Sheppard, John F. Krowka, Hans J. Bremermann
    Pages 203-210

  19. Inhibition of T Lymphocyte Activation and Apoptotic Cell Death by Cyclosporin a and Tacrolimus (FK506)

    • Angus W. Thomson, C. Andrew Bonham
    Pages 211-216

  20. Cyclophilin and Gag in HIV-1 Replication and Pathogenesis

    • Ettaly Kara Franke, Jeremy Luban
    Pages 217-228
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Keywords

About this book

In the past decade, the global efforts in the control of HIV disease were basically concentrated on the search for anti-retroviral agents. So far, anti-HIV therapies have been shown to be disappointing because of rapid development of drug-resistant mutant variants. Despite this drawback in the therapeutic fight against HIV infection, antiviral research should be actively pursued. However, failure of antiviral therapy indicates that other avenues of research should be rapidly explored with the same energy. In this setting, striking advances have been recently made in the dissection and understanding of the viro-immunological processes governing the progressive destruction of lymphoid organs associated with AIDS develop­ ment, and HIV-induced activation and apoptosis have been identified as key phenomena of the immune system destruction. This book assembles the most recent advances on basic and clinical aspects ofT-cell activationiapoptosis in HIV infection and their implications for immunotherapy. These data were presented at an international symposium held on July 11-12, 1994, in Paris. The book is partitioned into 21 chapters covering four comprehensive fields: 1) T-celllmacrophage activation and HIV infection; 2) Apoptosis and viropathogenesis of HI V disease; 3) Apop­ tosis and immunopathogenesis ofHIV disease; 4) Mediators ofT-cell activationiapoptosis and therapeutic applications. We hope that this book will assist the readers in understanding recent advances in the viro-immunopathogenesis of HI V disease as well as the rationales for potential immune­ cell-targeted therapeutic interventions.

Editors and Affiliations

  • Laennec Hospital, Paris, France

    Jean-Marie Andrieu, Wei Lu

Bibliographic Information

  • Book Title: Cell Activation and Apoptosis in HIV Infection

  • Book Subtitle: Implications for Pathogenesis and Therapy

  • Editors: Jean-Marie Andrieu, Wei Lu

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-1995-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1995

  • Hardcover ISBN: 978-0-306-45063-1Published: 30 June 1995

  • Softcover ISBN: 978-1-4613-5823-7Published: 21 October 2012

  • eBook ISBN: 978-1-4615-1995-9Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XI, 245

  • Topics: Immunology, Medical Microbiology, Plant Sciences, Animal Anatomy / Morphology / Histology, Microbial Ecology

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