Cell Activation and Apoptosis in HIV Infection

1. Front Matter

   Pages i-xi

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2. CD4+ and CD8+ T Lymphocyte Activation in HIV Infection

   • Jeffrey Laurence

   Pages 1-15

3. Markers of Immune Cell Activation and Disease Progression

   • M. Peakman, M. Mahalingam, A. Pozniak, T. J. McManus, A. N. Phillips, D. Vergani

   Pages 17-26

4. The Role of the Cell Cycle in HIV-1 Infection

   • Jerome A. Zack

   Pages 27-31

5. Molecular Basis of Cell Cycle Dependent HIV-1 Replication

   • M. Stevenson, B. Brichacek, N. Heinzinger, S. Swindells, S. Pirruccello, E. Janoff et al.

   Pages 33-45

6. Regulation of Macrophage Activation and HIV Replication

   • Luis J. Montaner, Georges Herbein, Siamon Gordon

   Pages 47-56

7. Investigations on Autologous T-Cells for Adoptive Immunotherapy of Aids

   • Jan van Lunzen, Jörn Schmitz, Kathrin Dengler, Claudia Kuhlmann, Herbert Schmitz, Manfred Dietrich

   Pages 57-70

8. Rational Problems Associated with the Development of Cellular Approaches in Controlling HIV Spread

   • Aldar S. Bourinbaiar, Sylvia Lee-Huang

   Pages 71-89

9. The Role of Surface CD4 in HIV-Induced Apoptosis

   • Jacques Corbeil, Douglas D. Richman

   Pages 91-99

10. Mechanism of Apoptosis in Peripheral Blood Mononuclear Cells Of HIV-Infected Patients

    • Naoki Oyaizu, Thomas W. Mc Closkey, Soe Than, Rong Hu, Savita Pahwa

    Pages 101-114

11. Programmed Death of T Cells in the Course of HIV Infection

    • Linde Meyaard, Frank Miedema

    Pages 115-120

12. T Cell Apoptosis as a Consequence of Chronic Activation of the Immune System in HIV Infection

    • Marie-Lise Gougeon

    Pages 121-127

13. Apoptosis During HIV Infection

    • Seamus J. Martin, Douglas R. Green

    Pages 129-138

14. From Cell Activation to Cell Depletion

    • Jean Claude Ameisen

    Pages 139-163

15. Immunosuppression by a Noncytolytic Virus Via T Cell Mediated Immunopathology

    • Rolf M. Zinkernagel

    Pages 165-171

16. Clonal Expansion of T Cells and HIV Genotypes in Microdissected Splenic White Pulps Indicates Viral Replication in Situ and Infiltration of HIV-Specific Cytotoxic T Lymphocytes

    • Rémi Cheynier, Sven Henrichwark, Fabienne Hadida, Eric Pelletier, Eric Oksenhendler, Brigitte Autran et al.

    Pages 173-182

17. Autoimmunity, Apoptosis Defects and Retroviruses

    • J. D. Mountz, J. Cheng, X. Su, J. Wu, T. Zhou

    Pages 183-201

18. Aids as Immune System Activation

    • Michael S. Ascher, Haynes W. Sheppard, John F. Krowka, Hans J. Bremermann

    Pages 203-210

19. Inhibition of T Lymphocyte Activation and Apoptotic Cell Death by Cyclosporin a and Tacrolimus (FK506)

    • Angus W. Thomson, C. Andrew Bonham

    Pages 211-216

20. Cyclophilin and Gag in HIV-1 Replication and Pathogenesis

    • Ettaly Kara Franke, Jeremy Luban

    Pages 217-228

In the past decade, the global efforts in the control of HIV disease were basically concentrated on the search for anti-retroviral agents. So far, anti-HIV therapies have been shown to be disappointing because of rapid development of drug-resistant mutant variants. Despite this drawback in the therapeutic fight against HIV infection, antiviral research should be actively pursued. However, failure of antiviral therapy indicates that other avenues of research should be rapidly explored with the same energy. In this setting, striking advances have been recently made in the dissection and understanding of the viro-immunological processes governing the progressive destruction of lymphoid organs associated with AIDS develop­ ment, and HIV-induced activation and apoptosis have been identified as key phenomena of the immune system destruction. This book assembles the most recent advances on basic and clinical aspects ofT-cell activationiapoptosis in HIV infection and their implications for immunotherapy. These data were presented at an international symposium held on July 11-12, 1994, in Paris. The book is partitioned into 21 chapters covering four comprehensive fields: 1) T-celllmacrophage activation and HIV infection; 2) Apoptosis and viropathogenesis of HI V disease; 3) Apop­ tosis and immunopathogenesis ofHIV disease; 4) Mediators ofT-cell activationiapoptosis and therapeutic applications. We hope that this book will assist the readers in understanding recent advances in the viro-immunopathogenesis of HI V disease as well as the rationales for potential immune­ cell-targeted therapeutic interventions.

• AIDS
• HIV
• HIV infection
• Pathogene
• development
• infection

• Laennec Hospital, Paris, France

  Jean-Marie Andrieu, Wei Lu

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