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The Brain Immune Axis and Substance Abuse

  • Book
  • © 1995

Overview

Editors:
  1. Burt M. Sharp

    1. Hennepin County Medical Center and University of Minnesota, Minneapolis, USA

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  2. Toby K. Eisenstein

    1. Temple University School of Medicine, Philadelphia, USA

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  3. John J. Madden

    1. Emory University School of Medicine, Atlanta, USA

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  4. Herman Friedman

    1. University of South Florida College of Medicine, Tampa, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 373)

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Introduction

    • Shannon Matta, David Saphier, Donald Lysle, Burt Sharp
    Pages 1-9

  3. Detection of К-Opioid Receptor mRNA in Immature T Cells

    • Stanley M. Belkowski, Jinmin Zhu, Lee Y. Liu-Chen, Toby K. Eisenstein, Martin W. Adler, Thomas J. Rogers
    Pages 11-16

  4. Identification of Opioid Receptors in the Immune System Using a Novel Combination of Selective Opioid Ligands and Indirect Phycoerythrin Immunofluorescence

    • Diane M. P. Lawrence, Sydney Archer, Jean M. Bidlack
    Pages 17-21

  5. Kappa Opioid Receptors on Three Related Thymoma Cell Lines

    • Jean M. Bidlack, David B. Joseph, Diane M. P. Lawrence
    Pages 23-27

  6. Delta Opioid Agonists Inhibit Proliferation of Highlypurified Murine CD4+ and CD8+ T-Cells

    • N. A. Shahabi, B. M. Sharp
    Pages 29-36

  7. Mitogenic Activation of Human T Lymphocytes Induces a High Affinity Morphine Binding Site

    • John J. Madden, David Ketelsen, William L. Whaley, Robert M. Donahoe, Dorothy Oleson
    Pages 37-40

  8. Morphine-Induced Suppression of Thymocyte Proliferation is Mediated by Inhibition of IL-2 Synthesis

    • Sabita Roy, Horace H. Loh, Roderick A. Barke
    Pages 41-48

  9. Active β-Endorphin Metabolites Generated by T-Cell Ectopeptidases

    • Bonnie C. Miller, Dwain L. Thiele, Don Rodd, Louis B. Hersh, G. Larry Cottam
    Pages 49-56

  10. The Cellular Basis for Opioid-Induced Immunosuppression

    • Liming Guan, Robert Townsend, Toby K. Eisenstein, Martin W. Adler, Thomas J. Rogers
    Pages 57-64

  11. Endogenous Opioid Peptides Suppress Cytokine-Mediated Upregulation of HIV-1 Expression in the Chronically Infected Promonocyte Clone U1

    • Chun C. Chao, Genya Gekker, Wen S. Sheng, Shuxian Hu, Philip S. Portoghese, Phillip K. Peterson
    Pages 65-72

  12. Relevance of Opioid Bimodality to Tolerance/Dependence Formation

    • Alan R. Gintzler
    Pages 73-83

  13. Agonist Induced Constitutive Receptor Activation as a Novel Regulatory Mechanism

    • Wolfgang Sadée, Zaijie Wang
    Pages 85-90

  14. Expression of Cannabinoid Receptor mRNA in Murine and Human Leukocytes

    • Yehia Daaka, Thomas W. Klein, Herman Friedman
    Pages 91-96

  15. Cannabinoid Stimulation of Arachidonate Metabolism in Human Peripheral Blood Mononuclear Leukocytes

    • Steven Specter, Sharon Diaz, Chang Liu
    Pages 97-101

  16. Marijuana, Receptors and Immunomodulation

    • Herman Friedman, Thomas W. Klein, Catherine Newton, Yehia Daaka
    Pages 103-113

  17. Mouse Strain Differences in in vivo and in vitro Immunosuppressive Effects of Opioids

    • Toby K. Eisenstein, Joseph J. Meissler Jr., Jeanine L. Bussiere, Thomas J. Rogers, Ellen B. Geller, Martin W. Adler
    Pages 115-121

  18. The Clastogenicity of Morphine Sulfate in vivo

    • David B. Couch, Satin G. Sawant
    Pages 123-129

  19. Cellular Mechanisms Involved in Morphine-Mediated Suppression of CTL Activity

    • Daniel J. J. Carr, Greg W. Carpenter, Hildegardo H. Garza Jr., Marc L. Baker, Bryan M. Gebhardt
    Pages 131-139

  20. Evidence for the Involvement of Macrophage-Derived Nitric Oxide in the Immunomodulatory Effect of Morphine and Aversive Pavlovian Conditioning

    • Donald T. Lysle, Karamarie Fecho, Kimberly A. Maslonek, Linda A. Dykstra
    Pages 141-147
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Keywords

About this book

This volume represents the proceedings of the 2nd annual symposium on the Brain Immune Axis and Substance Abuse held at the Breakers Hotel in Palm Beach, FL in June 1994. The history of productive studies concerning the relationship between the nervous and the immune systems is relatively recent. Studies on the effects of drugs of abuse on the immune system and on infections among individuals who abuse drugs are also of recent vintage. Only in the last decade have investigators begun to describe the role of drugs of abuse and their endogenous counterparts on the brain-immune axis. Thus, the involvement of the neuroendocrine system in the interactions of drugs of abuse and the immune system has only recently been appreciated. In addition, it has been recognized that direct neural inputs impact immune function. Given the complexity of these interactions, characterization of biologically significant phenomena and elucidation of their mechanisms of action often requires a multidisciplinary approach. This meeting, on which the chapters in this book are based, brought together scientists from an array of biomedical disciplines whose work is focused on the effects of drugs of abuse on the neuro-endocrine immune axis. The meeting was unique in focusing on the brain-immune axis from the viewpoint of drugs of abuse rather than either immunity itself or the brain itself. Presentations addressed the direct effects of drugs of abuse on various components of the immune system, as well as those mediated indirectly by the central nervous system and the neuroendocrine system.

Editors and Affiliations

  • Hennepin County Medical Center and University of Minnesota, Minneapolis, USA

    Burt M. Sharp

  • Temple University School of Medicine, Philadelphia, USA

    Toby K. Eisenstein

  • Emory University School of Medicine, Atlanta, USA

    John J. Madden

  • University of South Florida College of Medicine, Tampa, USA

    Herman Friedman

Bibliographic Information

  • Book Title: The Brain Immune Axis and Substance Abuse

  • Editors: Burt M. Sharp, Toby K. Eisenstein, John J. Madden, Herman Friedman

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-1951-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1995

  • Hardcover ISBN: 978-0-306-45017-4Published: 31 May 1995

  • Softcover ISBN: 978-1-4613-5801-5Published: 21 October 2012

  • eBook ISBN: 978-1-4615-1951-5Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: IX, 245

  • Topics: Immunology, Infectious Diseases, Neurology, Neurosurgery, Pharmacology/Toxicology

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