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Technical Advances in AIDS Research in the Human Nervous System

  • Book
  • © 1995

Overview

Editors:
  1. Eugene O. Major

    1. National Institute of Neurological Disorders and Stroke, Bethesda, USA

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  2. Jay A. Levy

    1. University of California, San Francisco, San Francisco, USA

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  3. Devera Schoenberg

    1. National Institute of Neurological Disorders and Stroke, Bethesda, USA

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-ix
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  2. New Concepts in the Pathogenesis of HIV-1 Encephalopathy

    1. Front Matter

      Pages 1-1
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    2. HIV Encephalopathy: Clinical and Diagnostic Considerations

      • Joseph R. Berger, Richard Kaderman
      Pages 3-25

    3. Cellular and Molecular Pathology of Novel Cerebral Diseases in AIDS

      • Peter L. Lantos
      Pages 27-40

    4. Peripheral Neuropathy in AIDS: New Investigative Approaches

      • John W. Griffin, Steven L. Wesselingh, Justin C. McArthur
      Pages 41-53

  3. Models of HIV-1 Infection and Neurotoxicity in the Human Fetal Nervous System

    1. Front Matter

      Pages 55-55
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    2. Overview: Models of HIV-1 Infection and Neurotoxicity in the Human Fetal Nervous System

      • Leon G. Epstein
      Pages 57-60

    3. HIV-1-Derived Neurotoxic Factors: Effects on Human Neuronal Cultures

      • Harris A. Gelbard, Kirk A. Dzenko, Leo Wang, Angela Talley, Harold James, Leon Epstein
      Pages 61-71

    4. Experimental Model Systems for Studies of HIV Encephalitis

      • Howard E. Gendelman, Peter Genis, Marti Jett, Hans S. L. M. Nottet
      Pages 73-88

    5. Cell Cultures from Human Fetal Brain Provide a Model for HIV-1 Persistence and Reactivation in the Central Nervous System

      • Eugene O. Major, Walter A. Atwood, Katherine E. Conant, Kei Amemiya, Judith Boston, Renee G. Traub
      Pages 89-103

    6. Use of Human Brain Cell Aggregates for AIDS Research in the Nervous System

      • Lynn Pulliam
      Pages 105-116

    7. Infection of Human Fetal Astrocytes with HIV

      • Avindra Nath, Meihui Ma
      Pages 117-122

  4. Model Cell Cultures from Adult Brain and Glioma Cell Lines

    1. Front Matter

      Pages 123-123
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    2. Molecular Interaction of HIV-1 in Glioma Cells

      • Volker Erfle, Andrea Kleinschmidt, Markus Neumann, Alexandra Ludvigsen, Barbara K. Felber, George N. Pavlakis et al.
      Pages 125-133

    3. Transcription of Human Immunodeficiency Virus Promoter in CNS-Derived Cells: Effect of TAT on Expression of Viral and Cellular Genes

      • Kamel Khalili, J. Paul Taylor, Crystina Cupp, Michael Zeira, Shohreh Amini
      Pages 135-149

    4. Tumor Necrosis Factor Alpha Derived from Human Microglia Enhances HIV-1 Replication and is Toxic for Rat Oligodendrocytes in Vitro

      • Susan G. Wilt, Jia Min Zhou, Steve Wesselingh, Conrad V. Kufta, Monique Dubois-Dalcq
      Pages 151-162

    5. Nitric Oxide Mediates a Component of gp120 Neurotoxicity in Primary Cortical Cultures

      • Valina L. Dawson, Ted M. Dawson
      Pages 163-173

  5. Neurotropism of HIV-1 Strains

    1. Front Matter

      Pages 175-175
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    2. Contribution of V3 and Reverse Transcriptase Sequence Analysis to Understanding the Concept of HIV-1 Neurotropism

      • Francesca Chiodi, Mariantonietta Di Stefano, Farideh Sabri
      Pages 177-188

    3. Sequence Analysis of Neuroinvasive and Blood-Derived HIV-1 nef Genes

      • Ruth Brack-Werner, Thomas Görblich, Thomas Werner, Francesca Chiodi, Lutz Gürtler, Josef Eberle et al.
      Pages 189-204
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Keywords

About this book

It is remarkable that each month the quantity ofarticles published on AIDS still that address numbers in the thousands. The basic, clinical and sociological aspects this epidemic have been vigorously investigated, and equally as extensively reported in traditional as well as new journals. Therefore, what can the reader ofthis volume expect to find that is different from the information already found in the literature? The authors of this text met in October 1993 to discuss not only AIDS and its effects on the nervous system but also to address the problem from the point of view of the diverse technologies that are used in understanding the disease. Just as the recog­ nition ofoncogenic viruses gave us insights into cellular genes that govern growth, the study ofHIV-I in the nervous system has opened new areas ofinvestigation in the nervous system. Use of human fetal and glioma-derived cell cultures, discovery of toxins in the nervous system, release and damage of cytokines in the brain, the neuropathic effects of HIV proteins, the investigation of new treatment for neuro­ AIDS, and virus detection strategies to identify latent HIVI infection are described in this volume. Basic and clinical investigators from more than thirty laboratories around the world contributed to the ideas discussed at the meeting, "Technical Advances in AIDS Research in the Human Nervous System.

Editors and Affiliations

  • National Institute of Neurological Disorders and Stroke, Bethesda, USA

    Eugene O. Major, Devera Schoenberg

  • University of California, San Francisco, San Francisco, USA

    Jay A. Levy

Bibliographic Information

  • Book Title: Technical Advances in AIDS Research in the Human Nervous System

  • Editors: Eugene O. Major, Jay A. Levy, Devera Schoenberg

  • DOI: https://doi.org/10.1007/978-1-4615-1949-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1995

  • Hardcover ISBN: 978-0-306-45000-6Published: 31 August 1995

  • Softcover ISBN: 978-1-4613-5800-8Published: 21 October 2012

  • eBook ISBN: 978-1-4615-1949-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: IX, 373

  • Topics: Immunology, Public Health, Epidemiology, Animal Anatomy / Morphology / Histology, Plant Sciences, Neurosciences

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