Endocrinology of Embryo—Endometrium Interactions

1. Front Matter

   Pages i-xi

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2. Endocrinology of Embryo-Endometrial Interactions: A Hundred Years of Fascinating Discoveries

   1. Endocrinology of Embryo-Endometrial Interactions: A Hundred Years of Fascinating Discoveries

      • Alexandre Psychoyos

      Pages 1-10

3. Contributions of Comparative Studies to Understanding Mechanisms of Implantation

   1. Contributions of Comparative Studies to Understanding Mechanisms of Implantation

      • Allen C. Enders

      Pages 11-16

4. Uterine Receptivity: Experimental Studies

   1. Cell Biology of Endometrial Receptivity and of Trophoblast-Endometrial Interactions

      • Hans-Werner Denker

      Pages 17-32

   2. Progesterone Directed Gene Expression in Rat Uterine Stromal Cells

      • Joy Mulholland, Deana Roy, Stanley Glasser

      Pages 33-39

   3. Cellular Aspects of Implantation in Ruminants

      • Michel Guillomot

      Pages 41-56

   4. Expression and Regulation of Insulin-Like Growth Factor Binding Protein-1 and Retinol Binding Protein in the Baboon (Papio anubis) Uterus

      • Asgerally T. Fazleabas, Harold G. Verhage

      Pages 57-65

   5. The Expression of Peptidase Antigens, CD10/Neutral Endopeptidase, CD13/Aminopeptidase N, and CD26/Dipeptidyl Peptidase IV in Human Endometrium

      • Hideharu Kanzaki, Kimitoshi Imai, Hiroshi Fujiwara, Michiyuki Maeda, Takahide Mori

      Pages 67-75

   6. Angiogenesis in the Rat Uterus During Pregnancy

      • Rolf H. B. Christofferson, B. Erik Wassberg, B. Ove Nilsson

      Pages 77-92

5. Uterine Receptivity: Clinical Studies

   1. Receptive and Refractory Period in Human Implantation

      • J. Mandelbaum, M. Plachot, A. M. Junca, J. Cohen, J. Salat-Baroux

      Pages 93-105

   2. Implantation of Human Blastocysts Following in Vitro Fertilisation

      • Virginia N. Bolton

      Pages 107-123

   3. Characterization of the Human Endometrium in Relation to Implantation

      • Peter C. Svalander, Paul V. Holmes, Kristina Gemzell-Danielsson, Marja-Liisa Swahn, Matts Wikland, Marc Bygdeman

      Pages 125-135

6. The M.C. Chang Memorial Lecture

   1. RU486: After Ten Years Novel Molecules and Reproductive Medicine

      • Etienne-Emile Baulieu

      Pages 137-161

7. Pregnancy Recognition

   1. Pregnancy Recognition

      • Takahide Mori, Hideharu Kanzaki

      Pages 163-165

   2. Hemopoietic Cytokine Regulation of Trophoblast Interferon, Ovine Trophoblast Protein-1

      • K. Imakawa, S. D. Helmer, L. A. Harbison, C. S. R. Meka, R. K. Christenson

      Pages 167-181

   3. Involvement of Local Mediators in Blastocyst Implantation

      • Thomas G. Kennedy

      Pages 183-194

   4. Immunoendocrine Functions of Trophoblast Interferons (IFN-τ or TP-1 or Trophoblastins) in the Maternal Recognition of Pregnancy

      • Jacques Martal, Nasser-Eddine Assal, Aines Assal, Kamel Zouari, Louis Huynh, Nicole Chêne et al.

      Pages 195-216

   5. The Decidual Hormones and Their Role in Pregnancy Recognition

      • Geula Gibori

      Pages 217-222

8. Endometrial Responses To Receptivity

   1. Embryo-Endometrial Interactions

      • Stephen K. Smith

      Pages 223-228

   2. Insulin-Like Growth Factors and Their Binding Proteins in the Endometrium

      • Liam J. Murphy

      Pages 229-244

Early embryonic loss is a continuing social and economic global problem. In human populations the estimates of interruptions early in pregnancy range from 35-60%. In animal husbandry (swine, ruminants) fully 30% of pregnancies fail to survive early events of gestation. The futility associated with this persistant high risk is even more unsettling because of advances made in assisted reproductive technology which, although this very selective methodology has added to our knowledge of embryo-endometrial interactions, has resulted in a birth rate of only 14%. These studies have instigated comparisons of the live relative contributions of the embryo and the uterus to the outcome of pregnancy. These analyses have shown that we have learned significantly less about the role of the uterus in deciding the outcome of either natural or assisted pregnancies. In 1979 a quotation by George Corner was used to set the tone of a meeting that was devoted to discussion of the cellular and molecular aspects of implantation. In spite of the proliferation in research activity which occurred in the following 15 years our real understanding of the embryo transfer process has fallen short of our expectations. We use the Corner quotation, once again, to preface this symposium so that we may recall that the fundamental nature of the process which regulates embryo-endometrial interactions still escapes us.

• Endometrium
• G proteins
• Insulin
• Uterus
• biology
• birth
• embryo
• endocrinology
• genes
• growth
• hormone
• hormones
• interaction
• pregnancy
• protein
• diabetes
• sexual behaviour

• Baylor College of Medicine, Houston, USA

  Stanley R. Glasser, Joy Mulholland

• Hôpital Bicêtre, Bâtiment INSERM Gregory Pincus, Bicêtre, France

  Alexandre Psychoyos

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