Free Radicals in Diagnostic Medicine

1. Front Matter

   Pages i-xvi

   PDF

2. Pathophysiology and Analysis

   1. Lipid Peroxides and Related Radicals in Clinical Medicine

      • Kunio Yagi

      Pages 1-15

   2. Reactive Oxygen Species in Normal Physiology, Cell Injury and Phagocytosis

      • Mary Treinen Moslen

      Pages 17-27

   3. Free Radical Mechanisms for Chromosomal Instability in Bloom’s Syndrome

      • Thomas M. Nicotera

      Pages 29-41

   4. The Analysis of Free Radicals, Lipid Peroxides, Antioxidant Enzymes and Compounds Related to Oxidative Stress as Applied to the Clinical Chemistry Laboratory

      • Donald Armstrong, Richard Browne

      Pages 43-58

3. Organ Specific Disorders

   1. Free Radicals and the Pathogenesis of Neuronal Death: Cooperative Role of Excitatory Amino Acids

      • Domenico E. Pellegrini-Giampietro

      Pages 59-71

   2. Free Radicals and Ocular Disease

      • Robert E. Anderson, Frank L. Kretzer, Laurence M. Rapp

      Pages 73-86

   3. Active Oxygen Mechanisms of UV Inflammation

      • Alice P. Pentland

      Pages 87-97

   4. Oxygen-Free Radicals at Myocardial Level: Effects of Ischaemia and Reperfusion

      • Roberto Ferrari

      Pages 99-111

   5. Mechanisms of Atherosclerosis: Role of LDL Oxidation

      • Peter D. Reaven

      Pages 113-128

   6. Tissue Iron Overload and Mechanisms of Iron-Catalyzed Oxidative Injury

      • Edward J. Lesnefsky

      Pages 129-146

   7. Free Radicals in the Pathophysiology of Pulmonary Injury and Disease

      • Daniel J. Brackett, Paul B. McCay

      Pages 147-163

   8. Lipid Peroxides in Hepatic, Gastrointestinal, and Pancreatic Diseases

      • Kunio Yagi

      Pages 165-169

   9. Reactive Oxygen Molecules in the Kidney

      • Wayne R. Waz, Leonard G. Feld

      Pages 171-183

   10. Reactive Oxygen Species (ROS) and Reproduction

       • Eve de Lamirande, Claude Gagnon

       Pages 185-197

4. Systemic Involvement

   1. Autoimmune and Inflammatory Diseases

      • Jonathan A. Leff

      Pages 199-213

   2. Antioxidants and Cancer: Molecular Mechanisms

      • Peter J. O’Brien

      Pages 215-239

   3. New Directions for Free Radical Cancer Research and Medical Applications

      • Stephen M. Hahn, C. Murali Krishna, James B. Mitchell

      Pages 241-251

   4. Shock and Multiple Organ Failure

      • Patricia A. Abello, Timothy G. Buchman, Gregory B. Bulkley

      Pages 253-268

   5. Role of Nutrients in the Cause and Prevention of Oxygen Radical Pathology

      • Harold H. Draper, William J. Bettger

      Pages 269-289

An International Syaposiua on Free Radicals in Diagnostic Medicine was co-sponsored by the state University of New York at Buffalo, Roswell Park Cancer Institute, and the Upstate NY Section of the American Association of Clinical Chemistry. The theme was "A Systems Approach To Laboratory Technology, Clinical Correlations And Antioxidant Therapy." The symposium was held on October 7-8, 1993 at the Hyatt Hotel and on October 9 at Roswell Park Cancer Institute, Buffalo, New York. This proceedings volume contains chapters from platform presentations, poster sessions and from invited special lectures in the areas of basic science, clinical applications and efficacy of treatment. A Special Lecture on the relevance of free radical analysis to clinical medicine was presented by Professor Kunio Yagi of Japan. The Yagi procedure to measure thiobarbituric acid (TBA) reaction reflects the amount of reactive substances, lipid peroxides and aldehydes, in the sample. For example, normal subjects will have less than 4 nmol/ml of serum lipid peroxides, while a person with diabetes generally has equal or greater than 5.0 and a diabetic person with vascular complications often exceeds 7.5 nmol/ml. Serum TBA is a clinically important measure that relates to aging, gender and estrogen as an antioxidant, in the prognosis for vascular disorders, and in pathological conditions relative to the amount of lipid peroxidation. The BASIC SCIENCES portion of the program examined: "Mechanisms of Action, Pathophysiology and Laboratory Tests" in six presentations.

• Lipid
• Oxidation
• antioxidant
• cancer
• chemistry
• lipide
• pathophysiology
• physiology
• research

• State University of New York at Buffalo, Buffalo, USA

  Donald Armstrong

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