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Cardiac Allograft Rejection

  • Book
  • © 2001

Overview

Editors:
  1. G William Dec

    1. Heart Failure & Transplantation Service, Harvard Medical School, Boston, USA

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  2. Jagat Narula

    1. Heart Failure/Transplantation Center, Hahnemann University School of Medicine, Philadelphia, USA

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  3. Manel Ballester

    1. Department of Cardiology, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Lleida, Spain

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  4. Ignasi Carrio

    1. Nuclear Medicine Department, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Immunopathology of Cardiac Allograft Rejection

    1. Front Matter

      Pages 1-1
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    2. Histocompatibility Antigens and Transplant Rejection

      • Shiv Pillai
      Pages 3-20

    3. Immunology of Cellular and Humoral Rejection after Cardiac Transplantation

      • Marlene L. Rose, Sudhir Kushwaha, Deirdre Cunningham
      Pages 21-47

    4. Immunobiology of Chronic Cardiac Allograft Rejection

      • Petri Koskinen, Jussi Tikkanen, Roope Sihvola, Pekka Häyry, Karl Lemström
      Pages 49-64

    5. Inflammatory Cell Infiltration, Cytokines, and Mechanisms of Myocyte Necrosis in Cardiac Transplant Rejection

      • Jay Bruce Sundstrom, Kimberley Cecile Jollow, Aftab Ahmed Ansari
      Pages 65-88

    6. Apoptosis in Cardiac Transplant Rejection

      • Mireia Puig, Navneet Narula, Jagat Narula
      Pages 89-100

    7. Pathology of Cardiac Allograft Vascular (Microvascular) Rejection: Impact on Patient Outcomes

      • Elizabeth H. Hammond, Robert L. Yowell, Dale G. Renlund
      Pages 101-125

    8. Strategies for the Induction of Allograft Tolerance

      • Thomas Wekerle, Josef Kurtz, Megan Sykes
      Pages 127-151

    9. Xenotransplantation: Hyperacute and Delayed Xenograft Rejection

      • Kwabena Mawulawde, Joren C. Madsen
      Pages 153-173

  3. Clinical Assessment and Management of Cardiac Allograft Rejection

    1. Front Matter

      Pages 175-175
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    2. Endomyocardial Biopsy Diagnosis of Cardiac Allograft Rejection

      • Barbara Czerska, Mary E. Keohane, Edward F. Philbin
      Pages 177-196

    3. Clinical Diagnosis and Management of Cardiac Allograft Rejection and Maintenance Immunosuppression

      • Thomas G. Di Salvo, G. William Dec
      Pages 197-232

    4. New Immunosuppressive Agents

      • J. F. Gummert, T. Ikonen, R. E. Morris
      Pages 233-266

    5. Treatment of Acute Vascular Rejection in Cardiac Allografts

      • Ilan S. Wittstein, Edward K. Kasper
      Pages 267-284

  4. Newer Diagnostic Tools for the Management of Cardiac Allograft Rejection

    1. Front Matter

      Pages 285-285
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    2. Evolution of Noninvasive Testing for the Detection of Cardiac Allograft Rejection

      • Rohit Srivastava, Jeffrey D. Hosenpud
      Pages 287-297

    3. Echocardiographic Diagnosis of Acute Allograft Rejection

      • Nadia Giannetti, Hannah A. Valantine
      Pages 299-320

    4. The Use of Magnetic Resonance Imaging in Cardiac Transplantation Rejection

      • Todd M. Koelling
      Pages 321-338

  5. Radionuclide Imaging for Surveillance of Cardiac Allograft Rejection

    1. Front Matter

      Pages 339-339
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Keywords

About this book

Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental immunologic mechanisms that are responsible for cellular and humorally-mediated immunity. Despite its successes, many clinical and scientific problems remain. One or more bouts of acute cellular or humoral (vascular) rejection will occur in over 75% of transplant recipients despite current immunosuppressive strategies. Further, rejection directly results in approximately 20% of post-transplant deaths and is believed to play a major role in the development of late allograft dysfunction and coronary vasculopathy.
This book by international experts in the fields of transplantation medicine, immunobiology and cardiac imaging provides the reader with an up-to-date, consise summary of the latest developments in the diagnosis and treatment of acute cardiac rejection. It is axiomatic that a more complete understanding of the pathogenic processes involved in rejection will ultimately lead to its prevention. This volume will be useful to transplant cardiologists, cardiovascular surgeons, cardiac pathologists and transplant scientists who seek to prolong the lifespan and improve the quality of life of their transplant recipients.

Editors and Affiliations

  • Heart Failure & Transplantation Service, Harvard Medical School, Boston, USA

    G William Dec

  • Heart Failure/Transplantation Center, Hahnemann University School of Medicine, Philadelphia, USA

    Jagat Narula

  • Department of Cardiology, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, Lleida, Spain

    Manel Ballester

  • Nuclear Medicine Department, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain

    Ignasi Carrio

Bibliographic Information

  • Book Title: Cardiac Allograft Rejection

  • Editors: G William Dec, Jagat Narula, Manel Ballester, Ignasi Carrio

  • DOI: https://doi.org/10.1007/978-1-4615-1649-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2001

  • Hardcover ISBN: 978-0-7923-7329-2Published: 30 September 2001

  • Softcover ISBN: 978-1-4613-5659-2Published: 24 October 2012

  • eBook ISBN: 978-1-4615-1649-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVII, 434

  • Topics: Transplant Surgery, Thoracic Surgery, Cardiology, Cardiac Surgery, Intensive / Critical Care Medicine

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