The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers.
This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment.
This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.

Keywords

Editors and Affiliations

Harvard Medical School, USA

Tucker Collins

Bibliographic Information

Book Title: Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control
Book Subtitle: Insights for Drug Discovery
Editors: Tucker Collins
DOI: https://doi.org/10.1007/978-1-4615-1565-4
Publisher: Springer New York, NY
eBook Packages: Springer Book Archive
Copyright Information: Springer Science+Business Media New York 2001
Hardcover ISBN: 978-0-7923-7223-3Published: 30 November 2000
Softcover ISBN: 978-1-4613-5617-2Published: 05 November 2012
eBook ISBN: 978-1-4615-1565-4Published: 06 December 2012
Edition Number: 1
Number of Pages: XIII, 327
Topics: Pathology, Microbiology, Veterinary Medicine/Veterinary Science, Biochemistry, general, Pneumology/Respiratory System

Publish with us

Policies and ethics

Editors:

Sections

Buy it now

Buying options

Other ways to access

Table of contents (9 chapters)

Front Matter

Back Matter

About this book