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Biochemistry and Genetics of Recq-Helicases

  • Book
  • © 2001

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Authors:
  1. David B. Lombard

    1. Massachusetts Institute of Technology, USA

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Table of contents (4 chapters)

  1. Front Matter

    Pages i-1
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  2. The RecQ-family helicases

    • David B. Lombard
    Pages 3-19

  3. Targeting the WRN Locus in the mouse

    • David B. Lombard
    Pages 21-41

  4. Interaction of the BLM protein with Topo III alpha in Somatic and meiotic cells

    • David B. Lombard
    Pages 43-58

  5. Nijmegen Breakage Syndrome disease protein and Mre11 at PML Nuclear Bodies and meiotic telomeres

    • David B. Lombard
    Pages 59-76

  6. Back Matter

    Pages 77-92
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Keywords

About this book

Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.

Authors and Affiliations

  • Massachusetts Institute of Technology, USA

    David B. Lombard

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