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Intractable Seizures

Diagnosis, Treatment, and Prevention

  • Book
  • © 2002

Overview

Editors:
  1. W. McIntyre Burnham

    1. University of Toronto, Toronto, Canada

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  2. Peter L. Carlen

    1. Toronto Western Research Institute, Toronto, Canada

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  3. Paul A. Hwang

    1. University of Toronto, Toronto, Canada

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 497)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Intractable Epilepsy in Adults

    1. Intractable Epilepsy in Adults

      • Ilo E. Leppik
      Pages 1-7

  3. Complex Partial Seizures

    1. Complex Partial Seizures

      • Warren T. Blume
      Pages 9-18

    2. Drug Therapy for Complex Partial Seizures

      • Joseph Bruni
      Pages 19-26

    3. Surgery for Complex Partial Seizures

      • John P. Girvin
      Pages 27-32

  4. West’s Syndrome (Infantile Spasms)

    1. West’s Syndrome (Infantile Spasms)

      • Richard A. Hrachovy
      Pages 33-50

    2. Drug Therapy for West’s Syndrome

      • Catherine Chiron, Olivier Dulac
      Pages 51-56

    3. Surgery for West’s Syndrome

      • Harold J. Hoffman
      Pages 57-59

  5. Lennox-Gastaut Syndrome

    1. Lennox-Gastaut Syndrome

      • Ernst Niedermeyer
      Pages 61-75

    2. Drug Therapy in Lennox-Gastaut Syndrome

      • Kevin Farrell
      Pages 77-86

    3. Surgery in Lennox-Gastaut Syndrome Corpus Callosum Division for Children

      • John R. Gates
      Pages 87-98

  6. Special Topic

    1. Early Versus Late Surgery for Intractable Seizures

      • Jerome Engel
      Pages 99-105

  7. Basic Pathophysiology—Theories and Research

    1. Why are Complex Partial Seizures Intractable?

      • W. McIntyre Burnham
      Pages 107-110

    2. Pathophysiology of Infantile Spasms

      • Harry T. Chugani
      Pages 111-121

    3. Functional Properties of Human Neocortical Neurons

      • Massimo Avoli, Donatella Mattia, Andre Olivier
      Pages 123-132

  8. Effects of Unchecked Seizures—Human and Animal Studies

    1. Psychiatric Aspects of Intractable Epilepsy

      • Dietrich Blumer
      Pages 133-147

    2. Neural Growth, Neural Damage and Neurotrophins in the Kindling Model of Epilepsy

      • Ronald J. Racine, Beth Adams, Philip Osehobo, Margaret Fahnestock
      Pages 149-170

    3. Effects of Uncontrolled Seizures

      • Carl E. Stafstrom, Gregory L. Holmes
      Pages 171-194

  9. New Therapeutic Strategies

    1. The Landau-Kleffner Syndrome

      • Hanna Kolski, Hiroshi Otsubo
      Pages 195-208

    2. Neuroprotective Strategies in Epilepsy

      • Peter L. Carlen, Marc R. Pelletier, Aviv Ouanounou, Michael Tymianski, Liang Zhang
      Pages 209-224
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Keywords

About this book

About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called `intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major `intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.

Editors and Affiliations

  • University of Toronto, Toronto, Canada

    W. McIntyre Burnham, Paul A. Hwang

  • Toronto Western Research Institute, Toronto, Canada

    Peter L. Carlen

Bibliographic Information

  • Book Title: Intractable Seizures

  • Book Subtitle: Diagnosis, Treatment, and Prevention

  • Editors: W. McIntyre Burnham, Peter L. Carlen, Paul A. Hwang

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-1335-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2002

  • Hardcover ISBN: 978-0-306-46621-2Published: 30 April 2002

  • Softcover ISBN: 978-1-4613-5503-8Published: 12 October 2012

  • eBook ISBN: 978-1-4615-1335-3Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 248

  • Topics: Neurology, Neurosciences

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