Diabetes and Cardiovascular Disease

1. Front Matter

   Pages i-xi

   PDF

2. Epidemiology and Genetic Determinants of Diabetes Mellitus

   1. Type 2 Diabetes in Youth: A New Epidemic

      • Heather Dean

      Pages 1-5

   2. Undiagnosed Diabetes Burden and Significance in the Canadian Population

      • T. Kue Young

      Pages 7-10

   3. Genes, Environment and Diabetes in Canadian Aboriginal Communities

      • Robert A. Hegele

      Pages 11-20

   4. Diabetes in Sub-Saharan Africa

      • Terry J. Aspray, Nigel Unwin

      Pages 21-26

   5. Coronary Heart Disease and Risk Factors in Asian Indians

      • Manisha Chandalia, Prakash C. Deedwania

      Pages 27-34

3. Metabolic Risk Factors in Diabetes and Cardiovascular Disease

   1. The Plasma Glucose Level - A Continuous Risk Factor for Vascular Disease in Both Diabetic and Non-Diabetic People

      • Hertzel C. Gerstein

      Pages 35-39

   2. Modified Lipoproteins and Cardiovascular Risk

      • Waleed Aldahi, Jiri Frohlich

      Pages 41-48

   3. Advances in Lipid-Lowering Therapy in Atherosclerosis

      • Jean Davignon

      Pages 49-58

   4. Homocysteine as a Risk Factor in Cardiovascular Disease

      • David E. C. Cole

      Pages 59-64

   5. Endothelial Integrity and Repair

      • Tsu-Yee Joseph Lee, Sabrena Noria, Joanne Lee, Avrum I. Gotlieb

      Pages 65-74

   6. Molecular Mechanisms of Endothelial Dysfunction in the Diabetic Heart

      • Peter Rösen, Xueliang Du, Zhi Sui Guang

      Pages 75-86

   7. A Study of Vascular Wound Healing in a Rabbit Model of Type I Diabetes

      • Natalie K. Schiller, Donald L. Akers, Brian Burke, Alvin M. Timothy, Brenda Bedi, Dennis B. McNamara

      Pages 87-96

   8. Endothelins in the Microvasculature and Heart in Diabetes

      • Subrata Chakrabarti, Shali Chen, Terry Evans, Morris Karmazyn

      Pages 97-108

   9. Diabetes and Endothelial Function: Implications for Coronary Angioplasty

      • Todd J. Anderson

      Pages 109-114

4. Hypertension and Diabetes Mellitus

   1. The Effect of Hypertension in Diabetes

      • Ellen D. Burgess

      Pages 115-117

   2. The Diabetic Hypertensive (or Hypertensive Diabetic) - A Compelling Need to Optimize Blood Pressure

      • S. George Carruthers

      Pages 119-125

   3. Left Ventricular Diastolic Dysfunction in Diabetic or Hypertensive Subjects: Role of Collagen Alterations

      • T. J. Regan, G. N. Jyothirmayi, C. Laham, A. Jain

      Pages 127-132

   4. Alterations in the Vascular Actions of Insulin in the Pathogenesis of Insulin Resistance and Hypertension

      • Subodh Verma, John H. McNeill

      Pages 133-142

   5. Cardiac Hypertrophy in Diabetes Patients With and Without Hypertension: Effects of Troglitazone, a Novel Antidiabetic Drug, on Diastolic Function

      • Naoki Makino, Hiroyoshi Hirayama, Hidetoshi Yonemochi, Ken-ichi Yano, Nobuyuki Abe

      Pages 143-148

Diabetes and cardiovascular disease together account for the largest portion of health care spending compared to all other diseases in Western society. This work seeks to provide an understanding of the causes of diabetes and its cardiovascular complications. As this understanding becomes more widely appreciated, it will serve as a foundation for evidence-based care and wider acceptance of sound science. The International Conference on Diabetes and Cardiovascular Disease, held in Winnipeg, in June 1999, was organized to bring together a multi-disciplinary group of researchers dedicated to further knowledge amongst researchers, care givers, and the managers of the health system. The invited speakers submitted their works for publication, which serves as the basis for this book. Major themes include: epidemiology of diabetes mellitus, metabolic risk factors in diabetes and cardiovascular disease, hypertension in diabetes mellitus, cardiac function in diabetes, glycemic control and improved cardiovascular function, diabetes management, and endothelial function in diabetes.

• Diabetes
• Diabetes mellitus
• cardiac function
• cardiovascular
• cardiovascular function
• hypertension
• insulin
• signal transduction

• Diabetes Research and Treatment Centre, Winnipeg, Canada

  Aubie Angel

• St. Boniface Research Centre, Winnipeg, Canada

  Naranjan Dhalla, Grant Pierce, Pawan Singal

Policies and ethics