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Hemophilia Care in the New Millennium

  • Book
  • © 2001

Overview

Editors:
  1. Dougald M. Monroe

    1. University of North Carolina School of Medicine, Chapel Hill, USA

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  2. Ulla Hedner

    1. Novo Nordisk A/S, Målov, Denmark
      University of Lund, Lund, Sweden

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  3. Maureane R. Hoffman

    1. Duke University and Durham VA Medical Centers, Durham, USA

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  4. Claude Negrier

    1. Hôpital Edouard Herriot, Lyon, France

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  5. Geoffrey F. Savidge

    1. Guys’ and St. Thomas’s Trust, London, UK

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  6. Gilbert C. White

    1. University of North Carolina School of Medicine, Chapel Hill, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 489)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Infectious Disease Risk

    1. The Transfusion-Transmitted Viruses in Blood Transfusion

      • Naomi L. C. Luban, Rima F. Jubran
      Pages 1-12

  3. Unexplained Aspects of Hemophilia and Hemostasis

    1. Are Patients with Glanzmann Thrombasthenia and the Bernard-Soulier Syndrome Protected Against Atherosclerosis?

      • Alan T. Nurden, Paquita Nurden, James N. George
      Pages 13-29

    2. Factor V: Dr. Jeckyll and Mr. Hyde

      • Michael Kalafatis, Kenneth G. Mann
      Pages 31-43

  4. Novel Approaches to Therapy

    1. Gene Therapy for Hemophilia B: Aav-Mediated Transfer of The Gene for Coagulation Factor IX to Human Muscle

      • Peter J. Larson, Katherine A. High
      Pages 45-57

    2. Use of Prophylaxis to Prevent Complications of Hemophilia

      • P. M. Mannucci, L. Mendolicchio, A. Gringeri
      Pages 59-64

    3. Factor Viii Inhibitors

      • Pete Lollar, John F. Healey, Rachel T. Barrow, Ernest T. Parker
      Pages 65-73

    4. Use of High Dose Factor Vila in Hemophilia Patients

      • Ulla Hedner
      Pages 75-88

  5. Inhibitor Development in Hemophilia Patients

    1. The Incidence of Inhibitors in Hemophilia A and the Induction of Immune Tolerance

      • Ernest Briët, Marjolein Peters
      Pages 89-97

    2. Mechanisms of B-cell Tolerance

      • Marc G. Jacquemin, Beatrijs Vanzieleghem, Jean-Marie R. Saint-Remy
      Pages 99-108

    3. Mechanisms of Unresponsiveness:T- And B-Cell Mediated Mechanisms of Anergy

      • Roberta Greenwood, Jeffrey Frelinger
      Pages 109-117

    4. CD4+ T Cells Specific for Factor VIII as a Target for Specific Suppression of Inhibitor Production

      • Mark T. Reding, Huiyun Wut, Mark Krampft, David K. Okita, Brenda M. Diethelm-Okita, Nigel S. Key et al.
      Pages 119-134

    5. CD40L Pathway Blockade as an Approach to Immunotherapy

      • Linda C. Burkly
      Pages 135-152

  6. Back Matter

    Pages 153-182
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Keywords

About this book

There should be, and in the best of cases there is, a synergy between basic research and patient care. However, this synergy is hard to develop because the techniques required to be a successful researcher are so different from the skills required to be an outstanding physician. Harold R. Roberts, M.D., of the University of North Carolina at Chapel Hill, is an example of a physician-researcher who has benefited from having his feet in both the world of patient care and the world of the laboratory: he has let clinical problems direct his basic research effort and conversely has adopted research advances in his care of patients. Dr. Roberts's long and continuing career has included many research and clinical advances. He was part of the first group to determine the amino acid sequence of the important thrombin inhibitor hirudin and part of the group that prepared the first cryoprecipitates which were the first alternative to plasma as therapy in hemophilia A. Dr. Roberts has made significant advances in understanding the protein chemistry behind hemophilia B; he was among the first researchers to identify some patients as not being completely deficient but instead as having measurable levels of protein and subsequently demonstrated that this protein was dysfunctional. This important advance led him to a classification scheme for patients into Cross Reacting Material (CRM) positive, negative, and reduced. Dr.

Editors and Affiliations

  • University of North Carolina School of Medicine, Chapel Hill, USA

    Dougald M. Monroe, Gilbert C. White

  • Novo Nordisk A/S, Målov, Denmark

    Ulla Hedner

  • University of Lund, Lund, Sweden

    Ulla Hedner

  • Duke University and Durham VA Medical Centers, Durham, USA

    Maureane R. Hoffman

  • Hôpital Edouard Herriot, Lyon, France

    Claude Negrier

  • Guys’ and St. Thomas’s Trust, London, UK

    Geoffrey F. Savidge

Bibliographic Information

  • Book Title: Hemophilia Care in the New Millennium

  • Editors: Dougald M. Monroe, Ulla Hedner, Maureane R. Hoffman, Claude Negrier, Geoffrey F. Savidge, Gilbert C. White

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-1277-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2001

  • Hardcover ISBN: 978-0-306-46521-5Published: 31 March 2001

  • Softcover ISBN: 978-1-4613-5474-1Published: 24 September 2012

  • eBook ISBN: 978-1-4615-1277-6Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 182

  • Topics: Internal Medicine, Hematology

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