Heart Cell Coupling and Impulse Propagation in Health and Disease

1. Front Matter

   Pages i-xiii

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2. The Cardiac Syncytium; An Overview

   • Walmor C. De Mello

   Pages 1-23

3. Connexin Interacting Proteins

   • Ralph J. Barker, Robert G. Gourdie

   Pages 25-50

4. Cardiovascular Connexins: Molecular Composition and Biochemical Regulation

   • Eric C. Beyer, Kyung Hwan Seul

   Pages 51-87

5. Heteromultimeric Gap Junction Channels: A Connection With Cardiac Physiology and Pathology

   • Alonso P. Moreno, Guoqiang Zhong, Volodya Hayrapetyan

   Pages 89-108

6. Intercellular Ca2+Signaling in the Cardiovascular System

   • Sylvia O. Suadicani, David C. Spray

   Pages 109-141

7. Biophysics of Gap Junction Channels

   • Richard D. Veenstra

   Pages 143-183

8. Phosphorylation of Connexin43 and Regulation of Cardiac Gap Junction

   • Issei Imanaga, Nobue Hirosawa, Hai Lin, Yasuji Sakamoto, Takashi Matsumura, Ken Mayama

   Pages 185-205

9. The Sinoatrial Node Gap Junction Distribution and Impulse Propagation

   • Mark R. Boyett, Haruo Honjo, Henggui Zhang, Yoshiko Takagishi, Itsuo Kodama

   Pages 207-234

10. Inward and Outward Currents and Cardiac Discontinuous Conduction

    • Mary B. Wagner, Ronald W. Joyner

    Pages 235-255

11. Cellular Electrical Uncoupling During Ischemia

    • Michiel J. Janse, Hanno L. Tan, Lukas R. C. Dekker, André G. Kléber

    Pages 257-282

12. Cell Coupling and Impulse Propagation in the Failing Heart:The Role of the Renin Angiotensin System

    • Walmor C. De Mello

    Pages 283-320

13. Gap Junctions and Connexin Expression in Human Heart Disease

    • Nicholas J. Severs

    Pages 321-334

14. Ionic Channels and Fibrillation

    • Justus M. B. Anumonwo, Omer Berenfeld, Amit Dhamoon, José Jalife

    Pages 335-359

15. Gap Junctions, Cardiac Excitability and Clinical Arrhythmias

    • Morton F. Arnsdorf, Peter J. Lee

    Pages 361-459

16. Back Matter

    Pages 461-470

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Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the generation of cardiac arrhythmias and heart failure. The different aspects and intricacies of heart cell communication is discussed by different authors, each one an expert in their own field.
The present publication will be of interest to cardiologists, electrophysiologists, heart physiologists, cardiac pharmacologists, biophysicists, and cell or molecular biologists.

• calcium
• cardiovascular
• cardiovascular system
• cells
• heart
• physiology
• research

• Department of Pharmacology Medical Sciences Campus, University of Puerto Rico, San Juan, USA

  Walmor C. Mello

• Department of Clinical and Experimental Cardiology Academic Medical Center, University of Amsterdam, The Netherlands

  Michiel J. Janse

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