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Mechanisms and Consequences of Proton Transport

  • Book
  • © 2002

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Editors:
  1. Tetsuro Urushidani

    1. Graduate School of Pharmaceutical Science, The University of Tokyo, Japan

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  2. John G. Forte

    1. Dept. of Molecular & Cell Biology, University of California at Berkeley, USA

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  3. George Sachs

    1. Center for Ulcer Research & Education, University of California, Los Angeles, USA

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Table of contents (40 chapters)

  1. Front Matter

    Pages iii-xiii
    Download chapter PDF

  2. Structure and Function of H,K-ATPase — Molecular Basis for Drug Targets

    1. The Gastric H,K-ATPase

      • Olga Vagin, Keith Munson, Jai Moo Shin, Nils Lambrecht, Steve Karlish, George Sachs
      Pages 1-17

    2. Human Nongastric H,K-ATPase: Current View On Structure And Functional Properties

      • Gail Adams, Manoranjani Tillekeratne, Nikolay B. Pestov, Nikolai N. Modyanov
      Pages 19-31

    3. Functional Consequences of Subunit Interactions in Na,K- and H,K-ATPases

      • Gilles Crambert, Pascal Beguin, Udo Hasler, Kathi Geering
      Pages 33-41

    4. HKcαEncodes Ouabain-insensitive H,K-ATPase in Surface Cells of Rat Distal Colon

      • Henry J. Binder
      Pages 43-52

    5. Molecular Diversity and Regulatory Heterogeneity of the H+,K+-ATPases in Kidney

      • Thomas D. Dubose Jr., Juan Codina, Jian Li
      Pages 53-58

    6. Mutational Analysis of Gastric Proton Pump, α- and β-Subunits

      • Shinji Asano, Tohru Kimura, Takeguchi Noriaki
      Pages 59-70

    7. Structure-Activity Relationships of Na,K-ATPase and H,K-ATPase

      • Jan Joep H. H. M. de Pont, Jan B. Koenderink, Herman G. P. Swarts, Peter H. G. M. Willems
      Pages 71-82

    8. The Effect of Mutations Within a Cluster of Homologous Amino Acids Present in the M5, M6 and M8 Transmembrane Regions of the H,K-ATPase

      • E. C. Rabon, S. J. Rulli, E. V. Skripnikov
      Pages 83-90

  3. Helicobacter Pylori and Mucosal Protection

    1. Host-Specific H. pylori Inhibition of H,K-ATPase α Subunit Gene Expression

      • Adam Smolka, Gö õ z Monika
      Pages 91-99

    2. H+K+-ATPase, the Dominant Gastric Autoantigen in Helicobacter pylori Infection

      • B. J. Appelmelk, M. P. Bergman, A. V. D. Aar, W. Lakhai, M. M. D’Elios, A. Azzurri et al.
      Pages 101-106

    3. The Gastric H/K ATPase in the Pathogenesis of Autoimmune Gastritis

      • Ban-Hock Toh, Mark Biondo, Aiden Marshall, Deanne Greenwood, John Sentry, Frank Alderuccio
      Pages 107-114

    4. Duodenal Protection: Influence of Melatonin and other Intestinal Transmitters on Duodenal Bicarbonate Secretion and Enterocyte Signaling

      • Gunnar Flemström, Markus Sjöblom
      Pages 115-122

    5. Role of Cytokines in Helicobacter pylori-Induced Gastric Epithelial Cell Matrix Metalloproteinase Secretion and Activation

      • Monika Gööz, Maria Shaker, Pal Gööz, Adam J. Smolka
      Pages 123-126

    6. HCl Causes Less Intracellular Acidification In Surface Epithelial Cells Of Isolated Necturus Gastric Mucosa Than Other Inorganic Acids

      • T. Kiviluoto, O. Nylander-Koski, H. Mustonen, E. Kivilaakso
      Pages 127-130

    7. Ethanol Increases Intracellular Free Calcium, Closes Gap Junctions and Decreases Cell Volume in Primary Cultured Rabbit Gastric Epithelial Cell Monolayers

      • H. Mustonen, T. Kiviluoto, E. Kivilaakso
      Pages 131-134

    8. Induction of Small Intestinal Damage by Inhibition of Both NO Synthase and COX-2

      • Akiko Tanaka, Shoko Hase, Tohru Miyazawa, Kenji Kanatsu, Koji Takeuchi
      Pages 135-137

    9. Role of Protein Kinases on Acid-Induced Duodenal Bicarbonate Secretion in Rats

      • Osamu Furukawa, Masahiko Hirokawa, Paul H. Guth, Eli Engel, Jonathan D. Kaunitz
      Pages 139-142

    10. Acid Induces Duodenal Epithelial Acidification and HC03 - Secretion via Activation of the Na+:HC03 - Cotransporter and CFTR in Mice

      • Masahiko Hirokawa, Osamu Furukawa, Paul H. Guth, Eli Engel, Shaoyou Chu, Marshall H. Montrose et al.
      Pages 143-145

  4. Gene Targeting Mouse — Mechanisms of Acid Secretion and Cell Proliferation

    1. Insights Into the Cell Biology, Development and Pathology of the Gastric Mucosa Revealed in Gastric H/K ATPase and Gastrin-Deficient Mice

      • Ian R. Van Driel, Teo V. Franic, Louise M. Judd, Simon P. Barrett, Katrina L. Scarff, Linda C. Samuelson et al.
      Pages 147-157
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Keywords

About this book

This volume represents the proceedings of the 9th International Proton Transport Conference, "Mechanisms and Consequences of Proton Transport" held in Leura, Australia, August 19 -21, 200 I. This conference has been held since 1971 every 3 to 4 years with few exceptions in association with the Congress of the International Union of Physiological Sciences. The first meeting was held in Frankfurt, Germany, at the Max-Planck'Institute. Countries hosting the conference have been Germany (twice), Sweden (twice), India, Canada, USA, Great Britain, and now Australia. Over the past 30 years participants at these Proton Transport Conferences have been principal contributors to the major discoveries in the physiology, biochemistry and pharmacology of gastric acid secretion. These include development of the H2-receptor blockers, defining the signaling pathways for the regulation of acid secretion, identifying the gastric proton pump, discovery and development of proton pump inhibitory drugs, and elucidating the physiology and biochemistry of Helicobacter pylori.

Editors and Affiliations

  • Graduate School of Pharmaceutical Science, The University of Tokyo, Japan

    Tetsuro Urushidani

  • Dept. of Molecular & Cell Biology, University of California at Berkeley, USA

    John G. Forte

  • Center for Ulcer Research & Education, University of California, Los Angeles, USA

    George Sachs

About the editors

Tetsuro Urushidani is an associate professor in the Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, The University of Tokyo. John G. Forte is a professor in the Department of Molecular and Cell Biology, University of California at Berkeley. George Sachs is Director of the Membrane Biology Laboratory, University of California, Los Angeles, Professor of Physiology and Medicine, UCLA, Wilshire Chair in Medicine, UCLA, and Co-Director of the Center for Ulcer Research and Education, UCLA.

Bibliographic Information

  • Book Title: Mechanisms and Consequences of Proton Transport

  • Editors: Tetsuro Urushidani, John G. Forte, George Sachs

  • DOI: https://doi.org/10.1007/978-1-4615-0971-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-1-4020-7059-4Published: 31 July 2002

  • Softcover ISBN: 978-1-4613-5330-0Published: 29 October 2012

  • eBook ISBN: 978-1-4615-0971-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 372

  • Topics: Cell Biology, Biochemistry, general, Gastroenterology, Anatomy, Microbiology, Animal Physiology

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