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Iron Chelation Therapy

  • Book
  • © 2002

Overview

Editors:
  1. Chaim Hershko

    1. Hebrew University School of Medicine, Jerusalem, Israel

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 509)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Animal Models of Hereditary Iron Transport Disorders

    • Nancy C. Andrews
    Pages 1-17

  3. Mechanism of Iron Toxicity

    • Antonello Pietrangelo
    Pages 19-43

  4. Role of Non-Transferrin-Bound Iron in The Pathogenesis of Iron Overload and Toxicity

    • Pierre Brissot, Olivier Loréal
    Pages 45-53

  5. Intracellular and Extracellular Labile Iron Pools

    • Z. Ioav Cabantchik, Or Kakhlon, Silvina Epsztejn, Giulianna Zanninelli, William Breuer
    Pages 55-75

  6. Cardioprotective Effect of Iron Chelators

    • Chaim Hershko, Gabriela Link, Abraham M Konijn
    Pages 77-89

  7. Results of Long Term Iron Chelation Treatment with Deferoxamine

    • Bernard A. Davis, John B. Porter
    Pages 91-125

  8. Long Term Deferiprone Chelation Therapy

    • Victor A Hoffbrand, Beatrix Wonke
    Pages 127-139

  9. Iron Chelator Chemistry

    • Zu D. Liu, Ding Y. Liu, Robert C. Hider
    Pages 141-166

  10. Structure-Activity Relationships Among Desazadesferrithiocin Analogues

    • Raymond J. Bergeron, Jan Wiegand, James S. McManis, William R. Weimar, Guangfei Huang
    Pages 167-184

  11. ICL670A: Preclinical Profile

    • Hanspeter Nick, Agnes Wong, Pierre Acklin, Bernard Faller, Yi Jin, René Lattmann et al.
    Pages 185-203

  12. Pyridoxal Isonicotinoyl hydrazone and its analogues

    • Joan L. Buss, Marcelo Hermes-Lima, Prem Ponka
    Pages 205-229

  13. Therapeutic Potential of Iron Chelators in Cancer Therapy

    • Des R. Richardson
    Pages 231-249

  14. Antimalarial Effect of Iron Chelators

    • Victor R. Gordeuk, Mark Loyevsky
    Pages 251-272

  15. Back Matter

    Pages 273-276
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Keywords

About this book

Within the last few years, iron research has yielded exciting new insights into the under­ standing of normal iron homeostasis. However, normal iron physiology offers little protec­ tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop­ ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Editors and Affiliations

  • Hebrew University School of Medicine, Jerusalem, Israel

    Chaim Hershko

Bibliographic Information

  • Book Title: Iron Chelation Therapy

  • Editors: Chaim Hershko

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-0593-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2002

  • Hardcover ISBN: 978-0-306-46785-1Published: 31 January 2003

  • Softcover ISBN: 978-1-4613-5148-1Published: 01 October 2012

  • eBook ISBN: 978-1-4615-0593-8Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 277

  • Topics: Inorganic Chemistry, Hematology, Veterinary Medicine/Veterinary Science

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