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Signal Transduction and Cardiac Hypertrophy

  • Book
  • © 2003

Overview

Editors:
  1. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  2. Larry V. Hryshko

    1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  3. Elissavet Kardami

    1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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  4. Pawan K. Singal

    1. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

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Part of the book series: Progress in Experimental Cardiology (PREC, volume 7)

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Table of contents (35 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Cardiac Adaptation and Remodeling

    1. Front Matter

      Pages 1-1
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    2. Molecular Changes of the Myocardium after Mechanical Circulatory Support

      • Florian Grabellus, Bodo Levkau, Hans-H. Scheld, Atsushi Takeda, Michael Erren, Jörg Stypmann et al.
      Pages 3-18

    3. Reverse Molecular Remodeling of the Failing Human Heart Following Support with a Left Ventricular Assist Device

      • Paul M. Heerdt, Daniel Burkhoff
      Pages 19-35

    4. Stretch-Elicited Autocrine/Paracrine Mechanism in the Heart

      • Horacio E. Cingolani, Néstor G. Perez, María C. Camilión de Hurtado
      Pages 37-48

    5. L-Arginine at the Crossroads of Biochemical Pathways Involved in Myocardial Hypertrophy

      • Emanuele Giordano, Lisa M. Shantz, Rebecca A. Hillary, Carlo Guarnieri, Claudio M. Caldarera, Anthony E. Pegg
      Pages 49-56

    6. Signal Transduction System in Human Aortic Smooth Muscle Cell Stimulated by Pure Pressure

      • Hideaki Kawaguchi, Noriteru Morita, Takeshi Murakami, Kenji Iizuka
      Pages 57-67

    7. Role of Mitochondrial KATP Channels in Improved Ischemic Tolerance of Chronically Hypoxic Adult and Immature Hearts

      • FrantiÅ¡ek Kolář, Ivana OÅ¡t’ádalová, Bohuslav OÅ¡t’ádal, Jan Neckář, Ondrej Szárszoi
      Pages 69-83

    8. Ca2+—Dependent Signaling Pathways Through Calcineurin and Ca2+ Calmodulin—Dependent Protein Kinase in Development of Cardiac Hypertrophy

      • Hiroyuki Takano, Yunzeng Zou, Hiroshi Akazawa, Toshio Nagai, Miho Mizukami, Haruhiro Toko et al.
      Pages 85-94

    9. Calreticulin, Cardiac Development and Congenital Complete Heart Block in Children

      • Barbara Knoblach, Kimitoshi Nakamura, Murray Robertson, Marek Michalak
      Pages 95-103

    10. Expression of Sodium-Calcium Exchanger Genes in Heart and Skeletal Muscle Development. Evidence for a Role of Adjacent Cells in Regulation of Transcription and Splicing

      • Marie Millour, Laurent Lescaudron, Alexander Kraev, Dmitri O. Levitsky
      Pages 105-123

    11. Na+/H+ Exchanger and Myocardial Hypertrophy

      • María C. Camilión de Hurtado, Néstor G. Pérez, Irene L. Ennis, Bernardo V. Alvarez, Horacio E. Cingolani
      Pages 125-135

  3. Cardiac Signal Transduction

    1. Front Matter

      Pages 137-137
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    2. Role of the Electrogenic Na+/HCO3 - Symport in the Heart

      • Ernesto Alejandro Aiello
      Pages 139-147

    3. Modulation of Atrial Natriuretic Peptide (ANP)-C Receptor and Associated Signaling by Vasoactive Peptides

      • Madhu B. Anand-Srivastava, Malika Boumati
      Pages 149-165

    4. Rab3 Small GTP—Binding Proteins: Regulation by Calcium/Calmodulin

      • Ranjinder S. Sidhu, Richard R. Clough, Rajinder P. Bhullar
      Pages 167-179

    5. Novel Aspects of Mechanical Signaling in Cardiac Tissue

      • Robert Denyer, Sandhya Sanghi, Rajesh Kumar, David E. Dostal
      Pages 181-198

    6. Caspase Activation in a Cardiac Cell-Free Model of Apoptosis

      • Claudio Stefanelli, Carla Pignatti, Benedetta Tantini, Emanuele D. Giordano Francesca Bonavita, Maddalena Zini, Flavio Flamigni et al.
      Pages 199-206

    7. The Role of the Voltage-Sensitive Release Mechanism in Contraction of Normal and Diseased Heart

      • Susan E. Howlett, Gregory R. Ferrier
      Pages 207-220

    8. Role of AT1 Receptor Blockade in Reperfused Myocardial Infarction

      • Bodh I. Jugdutt
      Pages 221-236
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Keywords

About this book

Cellular signaling in cardiac muscle refers to the myriad of stimuli and responses that direct and control the physiological operation of this organ. Our understand­ ing of these complex signaling cascades has increased dramatically over the past few decades with the advent of molecular tools for their dissection. Moreover, this infor­ mation is beginning to provide tangible targets towards manipulating cardiac func­ tion in the setting of cardiovascular disease. The mechanisms and factors that regulate cardiac cell growth are of particular interest as both adaptive and maladaptive responses can occur during cardiac hypertrophy. Cardiac hypertrophy describes the increase in individual cardiac myocyte size that is accomplished through the series and/or parallel addition of sarcomeres. The ability of cardiac muscle to increase in size through hyperplasia becomes highly restricted or negligible shortly after birth. Consequently, the increase in heart size associated with development and growth of an individual occurs through hypertrophy. In response to a chronic increase in workload, cardiac muscle cells can dramatically increase in size to face their increasing contractile demands. While this plasticity is clearly a ben­ eficial response under many conditions, it can be highly deleterious and inappropri­ ate under others. For example, cardiac hypertrophy associated with endurance exercise clearly enhances athletic performance. In contrast, the hypertrophy associated with chronic hypertension, stenotic or regurgitant heart valves, or following a myocardial infarction often continues far beyond the period where this adaptive response is ben­ eficial.

Editors and Affiliations

  • Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla, Larry V. Hryshko, Elissavet Kardami, Pawan K. Singal

Bibliographic Information

  • Book Title: Signal Transduction and Cardiac Hypertrophy

  • Editors: Naranjan S. Dhalla, Larry V. Hryshko, Elissavet Kardami, Pawan K. Singal

  • Series Title: Progress in Experimental Cardiology

  • DOI: https://doi.org/10.1007/978-1-4615-0347-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2003

  • Hardcover ISBN: 978-1-4020-7218-5Published: 31 January 2003

  • Softcover ISBN: 978-1-4613-5032-3Published: 31 October 2012

  • eBook ISBN: 978-1-4615-0347-7Published: 06 December 2012

  • Series ISSN: 1389-1774

  • Edition Number: 1

  • Number of Pages: XVII, 508

  • Topics: Cardiology

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