The Identities of Membrane Steroid Receptors

1. Front Matter

   Pages i-xiv

   PDF

2. “Nuclear” Receptors in the Membrane

   1. Membrane-Associated Estrogen Receptors and Breast Cancer

      • Diana C. Márquez, Richard J. Pietras

      Pages 1-9

   2. A Membrane Form of Estrogen Receptor-α Mediates Estrogenic, Nongenomic Effects

      • Cheryl Watson, Dragoslava Zivadinovic, Nataliya Bulayeva, Bridget Hawkins, Celeste Campbell, Bahiru Gametchu

      Pages 11-19

   3. An Expanded View of Estrogen Receptor Localization in Neurons

      • Teresa A. Milner, Stephen E. Alves, Shinji Hayashi, Bruce S. McEwen

      Pages 21-25

   4. Regulation of Endothelial No Synthase Activity by Estrogen Receptors in a Steroid Receptor Fast-Action Complex (SRFC) in Caveolae

      • Philip W. Shaul, Ken L. Chambliss, Chieko Mineo

      Pages 27-35

   5. Estrogen-Stimulated, Membrane-Initiated Receptor-Ligand Interactions in Vascular Cells

      • Li Lei, M. Page Haynes, Jeffrey R. Bender

      Pages 37-45

   6. Membrane Glucocorticoid Receptors and Glucocorticoid Signal Transduction

      • Bahiru Gametchu, Cheryl S. Watson

      Pages 47-55

   7. Nuclear Vitamin D (VDR) and Estrogen (ER) Receptors in the Membrane of Muscle and Breast Cancer Cells

      • Daniela Capiati, Graciela Santillán, Ana Rossi, Paula Monje, Ricardo Boland

      Pages 57-65

3. Nuclear Receptors Physically Interact with Signal Cascade Molecules

   1. The Role of Adapter Proteins in Eraα Membrane Association and Function

      • Robert X-D. Song, Rakesh Kumar

      Pages 67-76

   2. Interactions of Estrogen Receptors with Signal Cascade Molecules

      • Ferdinando Auricchio, Antimo Migliaccio, Gabriella Castoria, Marina Di Domenico

      Pages 77-83

   3. Human Progesterone Receptor Crosstalk with Cytoplasmic Signaling Molecules Through Direct SH3 Domain Interaction

      • Viroj Boonyaratanakornkit, Dean P. Edwards

      Pages 85-91

   4. The Classical Progesterone Receptor Mediates Xenopus Oocyte Maturation Through a Non-Genomic Mechanism

      • X. Johné Liu, J. V. Ruderman

      Pages 93-101

   5. Seteroid Hormone Receptor Interactions with PAK6, a Member of the P21 Activated Kinase Family

      • Steven P. Balk, Suzanne R. Lee

      Pages 103-110

   6. Membrane Localization and Rapid Non-Transcriptional Action of the Androgen Receptor

      • Sigrun Mink, Liubov Shatkina, Andrea Nestl, Andrew C. B. Cato

      Pages 111-117

   7. The Discovery and Function of MTA1s in Eraα Cytoplasmic Sequestration

      • Rui-An Wang, Rakesh Kumar

      Pages 119-124

4. Unique, Previously Undescribed Receptors

   1. Novel, Membrane-Intrinsic Receptors for Progesterone and Aldosterone

      • Ralf Lösel, Michael Christ, Christoph Eisen, Elisabeth Falkenstein, Martin Feuring, Christiane Meyer et al.

      Pages 125-129

   2. Current Knowledge of the Nature and Identity of Progestin and Estrogen Membrane Receptors in Fish Gonads

      • Peter Thomas, Zhu Yong, Pang Yefei

      Pages 131-137

   3. Evidence Supporting a Role for Gpr30, an Orphan Member of the G-Protein-Coupled Receptor Superfamily, in Rapid Estrogen Signaling

      • Edward J. Filardo, Jeffrey A. Quinn, C. Thomas Graeber

      Pages 139-146

   4. A Novel Non-Genomic Action of Estradiol (E) and Testosterone (T): Regulators of Microtubule Polymerization

      • Victor D. Ramirez, Jingjing Liu Kipp

      Pages 147-156

   5. Evidence that a Membrane Corticosteroid Receptor is an Opioid-Like Receptor

      • Frank L. Moore

      Pages 157-164

Cheryl S. Watson University o/Texas Medical Branch Cellular steroid action has been thoroughly studied in the nuclear compartment. However, nuclear steroid receptor mechanisms have been unable to explain some of the rapid activities of steroids, partiCUlarly those which occur in a time frame of seconds to minutes [reviewed in (1;2)]. Based on these and other considerations, an alternative membrane-associated receptor form was long ago proposed to exist (3). Others interpret the location of the steroid receptors mediating these rapid effects as peri­ membrane or cytoplasmic. New experimental tools have been brought to bear on the topic of receptors for steroids which mediate non-genomic actions, and thus investigative activity and focus regarding this type of steroid receptor has recently increased significantly. However, there may be multiple answers to the question "how do steroids mediate rapid nongenomic effects?" Steroid actions initiated at the cell membrane can impinge on important phases in the lifespan of a cell: proliferation, migration, differentiation, and release of hormones or neurotransmitters functioning as signals to other cells.

• G proteins
• Vitamin D
• enzymes
• estrogen receptor
• nuclear receptors
• proteins
• regulation
• signal transduction
• transcription
• diabetes

• University of Texas Medical Branch, USA

  Cheryl S. Watson

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