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  • Conference proceedings
  • © 2003

Retinal Degenerations

Mechanisms and Experimental Therapy

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 533)

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Table of contents (57 papers)

  1. Front Matter

    Pages i-xvi
  2. Identification of the RP1 and RP10 (IMPDH1) Genes Causing Autosomal Dominant RP

    • Stephen P. Daiger, Lori S. Sullivan, Sara J. Bowne, Avril Kennan, Peter Humphries, David G. Birch et al.
    Pages 1-11
  3. On the Role of IMPDH1 in Retinal Degeneration

    • Avril Kennan, Aileen Aherne, Sara J. Bowne, Stephen P. Daiger, G. Jane Farrar, Paul F. Kenna et al.
    Pages 13-18
  4. Mouse Genetic Approaches to Access Pathways Important in Retinal Function

    • Patsy M. Nishina, Jürgen K. Naggert
    Pages 29-34
  5. Retinal Degenerative Disorders in Southern Africa: A Molecular Genetic Approach

    • R.S. Ramesar, L. Roberts, G. Rebello, R. Goliath, A. Vorster, A. September et al.
    Pages 35-40
  6. Comparing Rod and Cone Function with Fundus Autofluorescence Images in Retinitis Pigmentosa

    • Anthony G. Robson, Catherine Egan, Graham E. Holder, Alan C. Bird, Fred W. Fitzke
    Pages 41-47
  7. A Modified Protocol for the Assessment of Visual Function in Patients with Retinitis Pigmentosa

    • N. Lodha, C. A. Westall, M. Brent, M. Abdolell, E. Héon
    Pages 49-57
  8. Prenatal Human Ocular Degeneration Occurs in Leber’s Congenital Amaurosis

    • Fernanda B. O. Porto, Isabelle Perrault, David Hicks, Jean-Michel Rozet, Noëlle Hanoteau, Sylvain Hanein et al.
    Pages 59-68
  9. Leber Congenital Amaurosis — Genotyping Required for Possible Inclusion in a Clinical Trial

    • Isabelle Perrault, Sylvie Gerber, Sylvain Hanein, Serge Picaud, Jean-Michel Rozet, Jean-Louis Dufier et al.
    Pages 69-77
  10. Proteomic Approaches to Understanding Age-Related Macular Degeneration

    • Joe G. Hollyfield, Robert G. Salomon, John W. Crabb
    Pages 83-89
  11. Progressive Pathways in Age-Related Macular Degeneration

    • Kimberly A. Howes, Jeanne M. Frederick, Alexander Marks, Wolfgang Baehr
    Pages 91-96
  12. Tissue Inhibitor of Metalloproteinases-3 and Sorsby Fundus Dystrophy

    • Jian Hua Qi, Quteba Ebrahem, Bela Anand-Apte
    Pages 97-105
  13. Mouse Models for Usher Syndrome 1b

    • Concepcion Lillo, Junko Kitamoto, Xinran Liu, Elizabeth Quint, Karen P. Steel, David S. Williams
    Pages 143-150
  14. Screen for Usher Syndrome 1b Mutations in the Ovine Myosin VIIa Gene

    • Tania Slatter, Sassan M. Azarian, Scott Tebbutt, Marion Maw, David S. Williams
    Pages 151-155

About this book

The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.
Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early or congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.

Editors and Affiliations

  • Beckman Vision Center, University of California, San Francisco, USA

    Matthew M. LaVail

  • Cole Eye Institute, The Cleveland Clinic Foundation, Cleveland, USA

    Joe G. Hollyfield

  • Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, USA

    Robert E. Anderson

Bibliographic Information

  • Book Title: Retinal Degenerations

  • Book Subtitle: Mechanisms and Experimental Therapy

  • Editors: Matthew M. LaVail, Joe G. Hollyfield, Robert E. Anderson

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-0067-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2003

  • Hardcover ISBN: 978-0-306-47781-2Published: 31 October 2003

  • Softcover ISBN: 978-1-4613-4909-9Published: 11 February 2013

  • eBook ISBN: 978-1-4615-0067-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVI, 467

  • Topics: Ophthalmology, Neurology, Neurosciences, Epidemiology, Tree Biology

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access