Tissue Engineering, Stem Cells, and Gene Therapies

1. Front Matter

   Pages i-ix

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2. Perspectives for Tissue Engineering and Stem Cells

   1. Tissue Engineering: Confronting the Transplantation Crisis

      • Robert M. Nerem

      Pages 1-9

   2. Human Embryonic Stem Cells — Realising the Potential

      • Jim McWhir, Alison Thomson, Virginie Sottile

      Pages 11-25

   3. Human Embryonic or Adult Stem Cells: An Overview on Ethics and Perspectives for Tissue Engineering

      • Philippe R. Henon

      Pages 27-45

   4. Stem Cell Biology and Plasticity

      • Emin Kansu

      Pages 47-55

3. Stem Cells In Tissue Engineering And Cell - Based Therapies

   1. Liver Tissue Engineering: Successes & Limitations

      • Vivek Dixit, Y. Murat Elçin

      Pages 57-67

   2. Pancreatic Islet and Stem Cell Transplantation in Diabetes Mellitus: Results and Perspectives

      • Reinhard G. Bretzel

      Pages 69-96

   3. Cell-Based Therapy of Chronic Degenerative Diseases of the Central Nervous System

      • Ye. V. Pankratov, A. I. Ivanov, T. D. Kolokoltsova, Ye. A. Nechayeva, I. F. Radayeva, L. I. Korochkin et al.

      Pages 97-105

   4. CD34+ Cells in Hematopoietic Stem Cell Transplantation

      • Taner Demirer

      Pages 107-118

   5. The Effects of Different Growth Factors on Human Bone Marrow Stromal Cells Differentiating into Hepatocyte-Like Cells

      • Yu-Shih Weng, Hsien-Yi Lin, Yi-Jung Hsiang, Cheng-Ta Hsieh, Wen-Tyng Li

      Pages 119-128

4. Biomarkers For Tissue-Engineered Products

   1. Oxidative DNA Damage Biomarkers Used in Tissue Engineered Skin

      • Henry Rodriguez, Pawel Jaruga, Mustafa Birincioğlu, Peter E. Barker, Catherine O’Connell, Miral Dizdaroğlu

      Pages 129-135

   2. Biomarkers Used to Detect Genetic Damage in Tissue Engineered Skin

      • Catherine O’Connell, Peter E. Barker, Michael Marino, Patricia McAndrew, Donald H. Atha, Pawel Jaruga et al.

      Pages 137-145

5. Biomaterials In Tissue Engineering And Repair

   1. Design Peptide Scaffolds for Regenerative Medicine

      • Shuguang Zhang, Carlos E. Semino

      Pages 147-163

   2. Progresses in Synthetic Vascular Prostheses: Toward the Endothelialization

      • Mathilde Crombez, Diego Mantovani

      Pages 165-177

   3. Adhesion and Growth of Rat Aortic Smooth Muscle Cells on Lactide-Based Polymers

      • Lucie Bačáková, Monika Lapčíková, Dana Kubies, František Rypáček

      Pages 179-189

   4. Biodegradable Copolymers Carrying Cell-Adhesion Peptide Sequences

      • Vladimír Proks, Lud’ka Machová, Štěpán Popelka, František Rypáček

      Pages 191-199

   5. Polymer Based Scaffolds and Carriers for Bioactive Agents from Different Natural Origin Materials

      • Patrícia B. Malafaya, Manuela E. Gomes, António J. Salgado, Rui L. Reis

      Pages 201-233

   6. Preparation and Characterization of Natural/Synthetic Hybrid Scaffolds

      • Gilson Khang, Sang Jin Lee, Chang Whan Han, John M. Rhee, Hai Bang Lee

      Pages 235-245

   7. Polyhipe Polymer: A Novel Scaffold forIn Vitro Bone Tissue Engineering

      • Maria Bokhari, Mark Birch, Galip Akay

      Pages 247-254

   8. Pancreatic Islet Culture and Transplantation Using Chitosan and PLGA Scaffolds

      • Y. Murat Elçin, A. Eser Elçin, Reinhardt G. Bretzel, Thomas Linn

      Pages 255-264

Recent years have seen an upsurge of significant interest in cell-based technologies. A range of productive and lively debate have taken place relating to tissue engineering, namely the construction of tissues and whole organs using molecularly-designed resorbable biomaterials to create tissue de novo, the potential use of human embryonic stem cells for transplantation and regenerative medicine, with similar potential for adult-derived stem cells, and gene therapy, in relation to cell transplantation. New findings in biomimetic materials, cell signalling pathways, extracellular matrix receptors and ligands, growth factors, and the human genome project, all present particularly motivating sources for the development of research in the evergrowing biomedical field. The purpose of this book is to stimulate further the work in biomedicine and to make the issues of related scientific disciplines accessible to a wider readership by characterising the current state of research in the biomedical field. The lectures and a selection of the presentations from BlOMED 200- th The 9 International Symposium on Biomedical Science and Technology, held in September 2002 in Turkey- constitute the basis for the volume. Tissue engineering, stem cells, cell and gene therapies were the major topics presented and discussed in the symposium. This book is intended to serve as an up-to-date synopsis of the major developments of our area through the work reflected in BlOMED 2002, though not covering all aspects of the topics, due to the natural restrictions within a volume of this kind.

• Biomaterial
• Tissue Engineering
• bone
• cartilage
• cells
• endothelium
• smooth muscle
• tissue

• Science Faculty and Biotechnology Institute, Ankara University, Ankara, Turkey

  Y. Murat Elçin

Policies and ethics