Overview
- Provides expert reviews of multiple metabolic targets covering the glycolytic pathway, Krebs cycle, tumor microenvironment, hypoxia, and therapeutic strategies
- Explores experimental models for evaluating the tumor metabolome to provide knowledge and access to the field
- Bridges the fields of cancer cell metabolism, tumor/stroma microenvironments, autophagy, drug discovery and development, and translational application of novel cancer therapies
- Includes supplementary material: sn.pub/extras
Part of the book series: Cancer Drug Discovery and Development (CDD&D)
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Table of contents (8 chapters)
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Front Matter
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Back Matter
Keywords
About this book
In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.
The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Tumor Metabolome Targeting and Drug Development
Editors: Steven Kanner
Series Title: Cancer Drug Discovery and Development
DOI: https://doi.org/10.1007/978-1-4614-9545-1
Publisher: Humana New York, NY
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4614-9544-4Published: 09 January 2014
Softcover ISBN: 978-1-4939-5343-1Published: 17 September 2016
eBook ISBN: 978-1-4614-9545-1Published: 07 January 2014
Series ISSN: 2196-9906
Series E-ISSN: 2196-9914
Edition Number: 1
Number of Pages: VIII, 198
Number of Illustrations: 10 b/w illustrations, 12 illustrations in colour
Topics: Cancer Research, Metabolomics, Molecular Medicine, Pharmacology/Toxicology