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Proteases in Health and Disease

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  • © 2013

Overview

Editors:
  1. Sajal Chakraborti

    1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, India

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  2. Naranjan S. Dhalla

    1. Institute of Cardiovascular Sciences, University of Manitoba, St. Boniface Hospital Research Centre, Winnipeg, Canada

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    You can also search for this editor in PubMed   Google Scholar

  • First volume to comprehensively explore the role of proteases in various diseases
  • Provides information on the pathogenesis of cellular dysfunction, with strong emphasis on identifying proteases and their endogenous inhibitors as targets for drug development
  • Utilizes a multidisciplinary approach to biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases?

Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 7)

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xv
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  2. Molecular and Biochemical Aspects of Proteases

    1. Front Matter

      Pages 1-1
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    2. An Overview of Endoplasmic Reticulum Calpain System

      • Krishna Samanta, Pulak Kar, Tapati Chakraborti, Sajal Chakraborti
      Pages 3-19

    3. Mitochondrial Calpains: Who, What, Where, When and Why?

      • James W. Geddes
      Pages 21-32

    4. Role of Calpains in Calmodulin Regulated Systems

      • Sreejit Parameswaran, Sujeet Kumar, Rajendra K. Sharma
      Pages 33-48

    5. Exercise and Matrix Metalloproteases in Health and Disease: A Brief Overview

      • Soni Shaikh, Animesh Chowdhury, Alok K. Banerjee, Jaganmay Sarkar, Sajal Chakraborti
      Pages 49-62

    6. Regulation of Chondrocyte Matrix Metalloproteinase Gene Expression

      • Charles J. Malemud
      Pages 63-77

    7. Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential

      • Ratnakar R. Chitte
      Pages 79-88

    8. Aspartic Proteolytic Inhibitors Induce Cellular and Biochemical Alterations in Fungal Cells

      • André L. S. Santos, Lys A. Braga-Silva, Bianca A. Silva, Vanila F. Palmeira, Roberta S. Valle, Érika A. Abi-chacra et al.
      Pages 89-119

    9. Cysteine Proteases of Human Malaria Parasites

      • Kailash C. Pandey
      Pages 121-134

    10. Proteases as Virulence Factors in Leishmania: Focus on Serine Proteases as Possible Therapeutic Targets

      • Partha Das, MD Nur Alam, Tripti De, Tapati Chakraborti
      Pages 135-161

    11. An Updated Inventory on Properties, Pathophysiology and Therapeutic Potential of Snake Venom Thrombin-Like Proteases

      • Ashis K. Mukherjee
      Pages 163-180

    12. Macrocyclic Protease Inhibitors Constrained into a β-Strand Geometry

      • Ashok D. Pehere, Andrew D. Abell
      Pages 181-192

  3. Involvement of Proteases in Disease Processes

    1. Front Matter

      Pages 193-193
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    2. Regulation of MT1-MMP Activation and Its Relevance to Disease Processes

      • Soumitra Roy, Tapati Chakraborti, Animesh Chowdhury, Kuntal Dey, Sajal Chakraborti
      Pages 195-213

    3. Role of Proteases During Intra-erythrocytic Developmental Cycle of Human Malaria Parasite Plasmodium falciparum

      • Sumit Rathore, Shaifali Jain, MohD Asad, Gaurav Datta, Pawan Malhotra, Asif Mohmmed
      Pages 215-242

    4. Proteases in Vibrio cholerae and Their Role in Pathogenesis

      • Amit Pal, Sun Nyunt Wai
      Pages 243-256

    5. ADAMTS13: The von Willebrand Factor Cleaving Protease and Its Role in Thrombotic Thrombocytopenic Purpura

      • Surbhi Saini, Tal Schiller, Andrew Wu, Chava Kimchi-Sarfaty
      Pages 257-276

    6. Role of Proteases and Their Tissue Inhibitors in Pregnancy Outcome

      • Sudhir C. Roy
      Pages 277-287

    7. Matrix Metalloproteinases in Bone Health and Disease

      • Stav Simsa-Maziel, Dalit Sela-Donenfeld, Efrat Monsonego-Ornan
      Pages 289-312
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Keywords

About this book

In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

Editors and Affiliations

  • Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, India

    Sajal Chakraborti

  • Institute of Cardiovascular Sciences, University of Manitoba, St. Boniface Hospital Research Centre, Winnipeg, Canada

    Naranjan S. Dhalla

About the editors

Dr. Sajal Chakraborti is a Senior Professor of Biochemistry at the University of Kalyani, West Bengal, India. His research covers the role of proteases in regulating pulmonary vascular tone under oxidant- and calcium-signaling phenomena. He has been engaged in teaching and research in biochemistry for the past 35 years.

Dr. Naranjan Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary research and education for promoting the scientific basis of cardiology, as well as training of professional manpower for combating heart disease for over 40 years.

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