Overview
- First volume to comprehensively explore the role of proteases in various diseases
- Provides information on the pathogenesis of cellular dysfunction, with strong emphasis on identifying proteases and their endogenous inhibitors as targets for drug development
- Utilizes a multidisciplinary approach to biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases
Part of the book series: Advances in Biochemistry in Health and Disease (ABHD, volume 8)
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Table of contents (23 chapters)
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Front Matter
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Proteases and Neural Disorders
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Front Matter
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Proteases and Cancer
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Front Matter
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Proteases and Cardiovascular Defects
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Front Matter
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Keywords
About this book
It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues.
Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.
Editors and Affiliations
About the editors
Sajal Chakraborti is a professor at the University of Kalyani, India.
Naranjan S. Dhalla is a professor at St. Boniface General Hospital and the University of Manitoba, Canada.
Bibliographic Information
Book Title: Role of Proteases in Cellular Dysfunction
Editors: Naranjan S. Dhalla, Sajal Chakraborti
Series Title: Advances in Biochemistry in Health and Disease
DOI: https://doi.org/10.1007/978-1-4614-9099-9
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2014
Hardcover ISBN: 978-1-4614-9098-2Published: 23 November 2013
Softcover ISBN: 978-1-4939-4634-1Published: 23 August 2016
eBook ISBN: 978-1-4614-9099-9Published: 22 November 2013
Series ISSN: 2512-2142
Series E-ISSN: 2512-2150
Edition Number: 1
Number of Pages: XI, 462
Number of Illustrations: 12 b/w illustrations, 46 illustrations in colour
Topics: Proteomics, Cell Physiology, Receptors, Cancer Research, Neurosciences, Biomedicine general